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Entry version 127 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

Pre-rRNA-processing protein TSR1 homolog

Gene

Tsr1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required during maturation of the 40S ribosomal subunit in the nucleolus.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-rRNA-processing protein TSR1 homolog
Alternative name(s):
Tsr1 ribosome assembly factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tsr1Imported
ORF Names:CG7338Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037073, Tsr1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0037073

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112801 – 814Pre-rRNA-processing protein TSR1 homologAdd BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei444Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VP47

PRoteomics IDEntifications database

More...
PRIDEi
Q9VP47

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VP47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037073, Expressed in embryo and 23 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VP47, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
65608, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VP47, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0077998

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VP47

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 249Bms1-type GPROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 67DisorderedSequence analysisAdd BLAST67
Regioni316 – 357DisorderedSequence analysisAdd BLAST42
Regioni392 – 448DisorderedSequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi317 – 341Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi394 – 423Acidic residuesSequence analysisAdd BLAST30
Compositional biasi424 – 447Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1980, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153195

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009858_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VP47

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGYRRFV

Database of Orthologous Groups

More...
OrthoDBi
186926at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VP47

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012948, AARP2CN
IPR039761, Bms1/Tsr1
IPR007034, BMS1_TSR1_C
IPR030387, G_Bms1/Tsr1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12858, PTHR12858, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08142, AARP2CN, 1 hit
PF04950, RIBIOP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00785, AARP2CN, 1 hit
SM01362, DUF663, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51714, G_BMS1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VP47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADHAFHRPG PLKQANKAHK TGRHRSKGAI DNAQKGKIGL RPISHKHKQQ
60 70 80 90 100
QRKEQRRNQM NQLRKNKREE VLEQKRKLGG QNTAPFLVCL LPMHEQIDPM
110 120 130 140 150
SALEILKSCD SELVVENSPS GIVYINLPRF KQRFAFVTPP VGRGNELIAL
160 170 180 190 200
DYLKVCDTTL LLTTAAFGDD EIFDRWGQRI FNMMSAQGIP TPVVALMDLE
210 220 230 240 250
SINPKRRPAA KQAAQKVISK LLPEEKIMQL DTASEALNVM RRIGGQKKRI
260 270 280 290 300
LHNVANRPHL FGDVVEFKPG SDPSDDLGTL EVTGFLRGQS LNVNGLVHIP
310 320 330 340 350
GLGDFQLSQV VAPPDPYKLD KSRDGENSEV RLLDRSDPSK RTSLQSENIP
360 370 380 390 400
DPMDAEQTWP TEDEIAASQA ETKKMKLVKR VPKGYSEYQA AWIPDVEEVE
410 420 430 440 450
DPDGKDDDDM SEDDDDDKED DNEDFMSCDN KSFEDEYEKR DSDTEEFQDT
460 470 480 490 500
VSVASEAAIN DEKYDQQMDF QEERETLKKL QQARTDQLWP DEIDTPLDVP
510 520 530 540 550
ARERFQKYRG LESFRTSPWD AKENLPADYA RIYQFQNFDR TKRRILNEAK
560 570 580 590 600
EFEGVLPGLY VTLYVINVPE SRWNAFKSAQ LMDNIIVYGM LPHEHQMCVM
610 620 630 640 650
NVVLQRMPDS EVPLKSKEQL IIQCGYRRFV VNPIYSQHTN GDKHKFERYF
660 670 680 690 700
RPYETVCATF YAPIQFPPAP VLAFKVNPDS TLALVARGRL LSCNPDRIVL
710 720 730 740 750
KRVVLSGHPM RINRKSASIR YMFFYKEDVE YFKPVKLRTK CGRLGHIKES
760 770 780 790 800
LGTHGHMKCY FDGQLRSYDT AFMYLYKRVF PKWTYEECLV RTAEHERQHA
810
SANRRSSQQV AMEE
Length:814
Mass (Da):93,717
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C9299F0F65556A3
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13820 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti570E → V in AAO24947 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51709.1
BT003192 mRNA Translation: AAO24947.1
BT044092 mRNA Translation: ACH92157.1
AY058591 mRNA Translation: AAL13820.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_649304.1, NM_141047.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078342; FBpp0077998; FBgn0037073

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7338

UCSC genome browser

More...
UCSCi
CG7338-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51709.1
BT003192 mRNA Translation: AAO24947.1
BT044092 mRNA Translation: ACH92157.1
AY058591 mRNA Translation: AAL13820.1 Different initiation.
RefSeqiNP_649304.1, NM_141047.4

3D structure databases

SMRiQ9VP47
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65608, 4 interactors
IntActiQ9VP47, 2 interactors
STRINGi7227.FBpp0077998

PTM databases

iPTMnetiQ9VP47

Proteomic databases

PaxDbiQ9VP47
PRIDEiQ9VP47

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
40360

Genome annotation databases

EnsemblMetazoaiFBtr0078342; FBpp0077998; FBgn0037073
GeneIDi40360
KEGGidme:Dmel_CG7338
UCSCiCG7338-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55720
FlyBaseiFBgn0037073, Tsr1
VEuPathDBiVectorBase:FBgn0037073

Phylogenomic databases

eggNOGiKOG1980, Eukaryota
GeneTreeiENSGT00940000153195
HOGENOMiCLU_009858_1_0_1
InParanoidiQ9VP47
OMAiCGYRRFV
OrthoDBi186926at2759
PhylomeDBiQ9VP47

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40360, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40360

Protein Ontology

More...
PROi
PR:Q9VP47

Gene expression databases

BgeeiFBgn0037073, Expressed in embryo and 23 other tissues
GenevisibleiQ9VP47, DM

Family and domain databases

InterProiView protein in InterPro
IPR012948, AARP2CN
IPR039761, Bms1/Tsr1
IPR007034, BMS1_TSR1_C
IPR030387, G_Bms1/Tsr1_dom
PANTHERiPTHR12858, PTHR12858, 1 hit
PfamiView protein in Pfam
PF08142, AARP2CN, 1 hit
PF04950, RIBIOP_C, 1 hit
SMARTiView protein in SMART
SM00785, AARP2CN, 1 hit
SM01362, DUF663, 1 hit
PROSITEiView protein in PROSITE
PS51714, G_BMS1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSR1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VP47
Secondary accession number(s): B5RIG8, Q86PD4, Q95TR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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