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Protein
Submitted name:

GH16847p

Gene

Q9VP46

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • GTPase activator activity Source: FlyBase
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GH16847pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Q9VP46Imported
Synonyms:Dmel\CG7324Imported
ORF Names:CG7324Imported, Dmel_CG7324Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037074 CG7324

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037074 Expressed in 12 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VP46, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078058

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini462 – 650Rab-GAP TBCInterPro annotationAdd BLAST189
Domaini849 – 884EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili727 – 747Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4347 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173529

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00NH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13354 PH-GRAM2_TCB1D9_TCB1D9B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036017 TCB1D9/TCB1D9B_PH-GRAM2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VP46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWIQPKELLL PSAFWIAEMH SRYFVLQKRR GHGESRGFGS MLVGTYDSVM
60 70 80 90 100
NTKPAPYRIL HQTPSSEVSY EIAIGITQDE IVKDWEWLKA NLFKVLDEME
110 120 130 140 150
NEDEVTNFTI CKIQSLYTQN NQDDTGESAD FKVMKSKFRQ IFKMPEEERL
160 170 180 190 200
VISYSATYVK NKIPRQGQLY ISLNHVCFYS YMLGQEIKRI IRFAELEDIS
210 220 230 240 250
RNANTIYLKT TNNMTYNFTM LFNASDAHLL IEQLNKMAIQ QLIHDPDSPV
260 270 280 290 300
VDHDTSNFSR LGSKTSKKPV LLRDLTARQK SEEFRIYFRL PQSEIIDGKI
310 320 330 340 350
KANIWTPYSK RFNSGFIYLS PNFFCFRSDV KDLVSVVIPM KTIKSVEKKD
360 370 380 390 400
DGQQRFENQI VIITSENVPF MFAHIVDRAV LISKITDLLA RVHVPLSRER
410 420 430 440 450
AKYDISWSKQ TALMNTFKTQ FSAEIIQKQE EKMVRWEAHF RDFGRGIGMF
460 470 480 490 500
RTTDVINLIV EGIPDKLRQE IWLIFSGAIH DKEMNPGLYE DLVEKAACIK
510 520 530 540 550
NCFAHDEIDR DLPRSLPEHP AFQSTDGIGA LRRVLQAYAL RNPQVGYCQA
560 570 580 590 600
MNIVSSVFLL FCDEENAFWM LASLCENLLP DYYKDKVVGA QIDQGVLNEL
610 620 630 640 650
VETHLPDLHG HLEQLGVIKM ISISWFLTIF MSVISYESSL HILDCFFYEG
660 670 680 690 700
AKIIFMISLQ IIEWNRDKLL ICQDDGEAML VLQNYLEGVY NPEYQVPPTT
710 720 730 740 750
DKRKMERKVQ TQTVQTLIHE AYTKFGEDIT QQRIEELRNK HRRLTMRQFD
760 770 780 790 800
IDNEKTIVKA YVQNPYFNRS ELHMLLTIIR EEKHALKSLQ QQQQKVQCPL
810 820 830 840 850
SETPQLVPQS TSRPIQDAGA SGGRYEAYSV SYEVFHTLFT ELTPWRKCVS
860 870 880 890 900
VDIGEKLFRL TDKKGTGVLD FGQLINALGL VCSNKNMEKL KLLYVLHLPP
910 920 930 940 950
LLSKAEIERS RRPRPRTKDD AEEAFEAEDF FDNDASESME ALPSPSDHNF
960 970 980 990 1000
DADDFALISA TQHLHNLAGI SGNTFMDLSR TPNLSVNSNT SSLAHRSSTF
1010 1020 1030 1040 1050
YVDLPGFQGT ATSTDAGRDE DELQRQLRQQ GRYESIDTFS DISDLGAARI
1060 1070 1080 1090 1100
TPPEAGVGAD VVAGAASSAA ADHMLLNVET ISNFSQISDL VAATRLERVD
1110 1120 1130 1140 1150
SNATDLRSLG SLGYLLDQPD EGASNSQHSI PHMRKENFQL LWRSIIEIMG
1160 1170 1180 1190 1200
LVQDEEMQRA YENLLELGNS NIKKEPSLES FTQLNMGGDE QPDSNGNPTT
1210 1220 1230 1240 1250
PAPEPIGTTR LFVALEEELR QASGKSRTTT TSSGDSSSTN ISESWHISIT
1260 1270 1280 1290
QFIATVLTVN SIVRGFQTPI QISEQIEQLQ KKRRKCLSTN Y
Length:1,291
Mass (Da):147,264
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A78849681035663
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PIF1M9PIF1_DROME
Uncharacterized protein, isoform B
Dmel\CG7324 Q9VP46, CG7324, Dmel_CG7324
1,256Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51710.1
BT015288 mRNA Translation: AAT94517.1

NCBI Reference Sequences

More...
RefSeqi
NP_649305.1, NM_141048.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.20131

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078404; FBpp0078058; FBgn0037074

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40361

UCSC genome browser

More...
UCSCi
CG7324-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51710.1
BT015288 mRNA Translation: AAT94517.1
RefSeqiNP_649305.1, NM_141048.2
UniGeneiDm.20131

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

IntActiQ9VP46, 3 interactors
STRINGi7227.FBpp0078058

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078404; FBpp0078058; FBgn0037074
GeneIDi40361
UCSCiCG7324-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0037074 CG7324

Phylogenomic databases

eggNOGiKOG4347 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000173529
OrthoDBiEOG091G00NH

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40361

Gene expression databases

BgeeiFBgn0037074 Expressed in 12 organ(s), highest expression level in brain

Family and domain databases

CDDicd13354 PH-GRAM2_TCB1D9_TCB1D9B, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR036017 TCB1D9/TCB1D9B_PH-GRAM2
PfamiView protein in Pfam
PF02893 GRAM, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VP46_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VP46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: December 5, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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