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Protein

Calcium-transporting ATPase

Gene

SPoCk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: FlyBase
  • manganese-transporting ATPase activity Source: FlyBase
  • proton-exporting ATPase activity, phosphorylative mechanism Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:SPoCkImported
Synonyms:anon-WO0118547.249Imported, CG14449Imported, CG7651Imported, Dmel\CG32451Imported, SPoCKImported
ORF Names:CG32451Imported, Dmel_CG32451Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0052451 SPoCk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 79HelicalUniRule annotationAdd BLAST19
Transmembranei85 – 104HelicalUniRule annotationAdd BLAST20
Transmembranei252 – 270HelicalUniRule annotationAdd BLAST19
Transmembranei282 – 306HelicalUniRule annotationAdd BLAST25
Transmembranei758 – 777HelicalUniRule annotationAdd BLAST20
Transmembranei828 – 846HelicalUniRule annotationAdd BLAST19
Transmembranei858 – 879HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9VNR2

Expressioni

Gene expression databases

BgeeiFBgn0052451 Expressed in 23 organ(s), highest expression level in head
ExpressionAtlasiQ9VNR2 baseline and differential
GenevisibleiQ9VNR2 DM

Interactioni

Protein-protein interaction databases

IntActiQ9VNR2, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9VNR2
SMRiQ9VNR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 81Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00890000139334
OrthoDBiEOG091G0NXU

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9VNR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLSTSESST HSASEVAGRL QVDVRTGLKW TEAKYRAKII GHNELLLVAE
60 70 80 90 100
DPTWKKYIEQ FRNPLILLLL GSALVSVIMK QFDDAVSITI AILIVVTVAF
110 120 130 140 150
IQEYRSEKSL EELKKLVPPE CHCLREGRLD TFLARELVPG DIVHLNVGDR
160 170 180 190 200
VPADVRLFEA VDLSIDESSF TGETEPARKI TDVLLNNTNV KDHSNMKNIA
210 220 230 240 250
FMGTLVRCGN GKGIVVSTGE RSEFGEVFKM MQAEEAPKTP LQKSMDILGA
260 270 280 290 300
QLSFYSFLII GVIMLLGWLQ GKPLSEMFNI SVSLAVAAIP EGLPIVVTVT
310 320 330 340 350
LALGVMRMAK RNSIVKKLPT VETLGCVNVI CSDKTGTLTK NEMTATIIIT
360 370 380 390 400
SDGYMADVTG AGYNDQGEIH IRHCNNVEMA KTNITNLLEI GAVCNNAYIQ
410 420 430 440 450
NGTLLGQPTE GALVAVAMKN GMYATAENYV RIQEYPFSSE QKMMAVKCIH
460 470 480 490 500
KYNNNKEEIF FAKGALETLL PQCTKYQFGT QTVPLTKQNE AEFLAEAYEI
510 520 530 540 550
GRKGLRVLAL AKGRSMQDLI YCGLVGITDP PRPLVRESIE MLMQSGVRVK
560 570 580 590 600
MVTGDAQETA LAIANLIGID TIHHQTLSGQ EMDQMNEHQL DKVANNVSVF
610 620 630 640 650
YRVSPRHKLE IVKSLQRSGN IVGMTGDGVN DGVALKKADI GIAMGKNGTD
660 670 680 690 700
VCKEAADMIL VNDDFHTIIA AIEEGKGIFY NIRNFVRFQL STSIAALALI
710 720 730 740 750
ALATLMDIAN PLNAMQILWI NIIMDGPPAQ SLGVEPVDHD VLKQKPRNVK
760 770 780 790 800
QPMITKSVVV NVLLSASIIV LGTLWVFQRE MADGTLGKTK RDTTMTFTCF
810 820 830 840 850
VFFDMFNALS CRSQTKSVFT IGLTTNRMFL LAVAFSIIGQ MLVVYFPPLQ
860 870 880 890 900
MVFQTEALTP YDIFFLVSLT SSVLVVSEIK KWFERTMERK MYSTRSELDF

V
Length:901
Mass (Da):99,546
Last modified:May 1, 2000 - v1
Checksum:iDBB417DC2CA110DA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7KTU2Q7KTU2_DROME
Calcium-transporting ATPase
SPoCk anon-WO0118547.249, CG14449, CG7651, Dmel\CG32451, SPoCK
1,034Annotation score:
Q8IPS6Q8IPS6_DROME
Calcium-transporting ATPase
SPoCk anon-WO0118547.249, CG14449, CG7651, Dmel\CG32451, SPoCK
924Annotation score:
C1C5A0C1C5A0_DROME
Calcium-transporting ATPase
SPoCk anon-WO0118547.249, CG14449, CG7651, Dmel\CG32451, SPoCK
917Annotation score:
A8JNX2A8JNX2_DROME
Calcium-transporting ATPase
SPoCk anon-WO0118547.249, CG14449, CG7651, Dmel\CG32451, SPoCK
997Annotation score:
M9PG15M9PG15_DROME
Secretory pathway calcium atpase, i...
SPoCk anon-WO0118547.249, CG14449, CG7651, Dmel\CG32451, SPoCK
1,062Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51860.1
RefSeqiNP_730745.1, NM_168963.4
UniGeneiDm.31157

Genome annotation databases

EnsemblMetazoaiFBtr0078531; FBpp0078183; FBgn0052451
GeneIDi40495
UCSCiCG32451-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51860.1
RefSeqiNP_730745.1, NM_168963.4
UniGeneiDm.31157

3D structure databases

ProteinModelPortaliQ9VNR2
SMRiQ9VNR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VNR2, 2 interactors

Proteomic databases

PRIDEiQ9VNR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0078531; FBpp0078183; FBgn0052451
GeneIDi40495
UCSCiCG32451-RA d. melanogaster

Organism-specific databases

CTDi40495
FlyBaseiFBgn0052451 SPoCk

Phylogenomic databases

GeneTreeiENSGT00890000139334
OrthoDBiEOG091G0NXU

Enzyme and pathway databases

ReactomeiR-DME-936837 Ion transport by P-type ATPases

Miscellaneous databases

GenomeRNAii40495

Gene expression databases

BgeeiFBgn0052451 Expressed in 23 organ(s), highest expression level in head
ExpressionAtlasiQ9VNR2 baseline and differential
GenevisibleiQ9VNR2 DM

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VNR2_DROME
AccessioniPrimary (citable) accession number: Q9VNR2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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