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UniProtKB - Q9VN82 (Q9VN82_DROME)
Protein
Submitted name:
Canoe, isoform E
Gene
cno
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
- protein domain specific binding Source: FlyBase
- small GTPase binding Source: FlyBase
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- compound eye development Source: FlyBase
- dorsal closure Source: FlyBase
- embryonic morphogenesis Source: FlyBase
- epidermis morphogenesis Source: FlyBase
- establishment of mitotic spindle orientation Source: FlyBase
- glial cell proliferation Source: FlyBase
- ommatidial rotation Source: FlyBase
- positive regulation of smoothened signaling pathway Source: FlyBase
- regulation of establishment of planar polarity Source: FlyBase
- regulation of JNK cascade Source: FlyBase
- regulation of protein localization Source: FlyBase
- second mitotic wave involved in compound eye morphogenesis Source: FlyBase
- signal transduction Source: InterPro
Keywordsi
Biological process | Cell adhesionARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Canoe, isoform EImportedSubmitted name: Canoe, isoform JImportedSubmitted name: FI05483pImported |
Gene namesi | Name:cnoImported Synonyms:AF-6Imported, anon-WO0172774.47Imported, CanoeImported, CG2534Imported, CG31537Imported, CnoImported, cno-RBImported, cno?Imported, dlhAImported, Dmel\CG42312Imported, EC3-10Imported, lipImported, misImported ORF Names:CG42312Imported, Dmel_CG42312Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0259212, cno |
VEuPathDBi | VectorBase:FBgn0259212 |
Subcellular locationi
Plasma Membrane
- cytoplasmic side of plasma membrane Source: FlyBase
Other locations
- adherens junction Source: FlyBase
- cell cortex Source: FlyBase
- cell-cell junction Source: FlyBase
- rhabdomere Source: FlyBase
Interactioni
GO - Molecular functioni
- cell adhesion molecule binding Source: GO_Central
- protein domain specific binding Source: FlyBase
- small GTPase binding Source: FlyBase
Protein-protein interaction databases
IntActi | Q9VN82, 3 interactors |
STRINGi | 7227.FBpp0289752 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 133 | Ras-associatingInterPro annotationAdd BLAST | 95 | |
Domaini | 256 – 348 | Ras-associatingInterPro annotationAdd BLAST | 93 | |
Domaini | 689 – 917 | DiluteInterPro annotationAdd BLAST | 229 | |
Domaini | 1012 – 1097 | PDZInterPro annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 142 – 203 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 224 – 257 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 345 – 372 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 493 – 545 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 580 – 619 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1117 – 1148 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1185 – 1251 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 1285 – 1355 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 1412 – 1453 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 1473 – 1538 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 1562 – 1586 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1691 – 1752 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 1992 – 2051 | DisorderedSequence analysisAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1630 – 1660 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 144 – 166 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 167 – 201 | Polar residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 229 – 249 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 493 – 510 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 511 – 525 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 526 – 545 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 580 – 599 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1189 – 1218 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1232 – 1251 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1286 – 1355 | Polar residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 1473 – 1498 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 1516 – 1537 | Pro residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1562 – 1579 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1709 – 1723 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2012 – 2051 | Basic and acidic residuesSequence analysisAdd BLAST | 40 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1892, Eukaryota |
GeneTreei | ENSGT00940000155237 |
OrthoDBi | 117649at2759 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q9VN82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHDKKMLDR EAVRSVIQQW NANRLDLFAL SEPDENLLFH GVMRFYFQDA
60 70 80 90 100
GQKVATKCIR VASDATVTDV IDTLIEKFRP DMRMLSVPNY ALYEVHANGE
110 120 130 140 150
ERRLNADEKP LLVQLNWHID DREGRFLLKN IDQKTTPIEQ TDLNFKRKLS
160 170 180 190 200
KREKKEQKKK EKMAKLSSDP PTSNGSHLGL GNGVGASSGS AHMNGNAGGT
210 220 230 240 250
GGDSSDAVAG KLYTELPETS FTRSISNPEA VMRRRRQQKL EKKLQQFRSR
260 270 280 290 300
DGGPDTGGTL KIYGESLCQD VPYKTLLLSI RDCAQAVVRE MLTKYGLEKA
310 320 330 340 350
DPLHYCLVQV NSDGTEYILD DDECPLSILM NHPTSRGSIM FHVRRRPADS
360 370 380 390 400
QPRRRKKKPL GAANGANHIS GDREGPVLVE VTHSGDGGRR IKLGSDPVEV
410 420 430 440 450
GSANTNCLQL FGPSIQPRHC LISLLEGVCT VTPLHTDALT FVNGHHISQP
460 470 480 490 500
TILHNGSVVM FGRVASYRFL DSPTDGRYNL ALSQSQLDSA CLYESRSPTS
510 520 530 540 550
PGSWNDEDGA LSSTHKSDYD HHQQANHSSA YHNNNNNSSD HPLSSTLRDV
560 570 580 590 600
VDSKAGQDQG ANSGNYDGQS LEGNLENETK SISSLKSGGS NSQDRSPKMT
610 620 630 640 650
GSGILAGGGS GSGDTQGQEP ILPAVLEFPE THQELFLRHI ISELDVNVPH
660 670 680 690 700
FKLAPVYSLY LCARYRASTH YRPELQPTER AHKLTMFLHH VANLVYSVVQ
710 720 730 740 750
EQYTDPRILA FWMANSSEFL HFLKSDRHIS AFSVQAQEVL AEAVQTAFRN
760 770 780 790 800
LVNCFRLELS QTLNQFLSEN IDHDSAAGLV LTVLGSAMAL LRRCRVNAAL
810 820 830 840 850
TIQLFSQLFH YINVICFNTI VANSQMCTGD WGKVMTERLQ LLELWAERQG
860 870 880 890 900
LELAADCHLA KINQCAQFLQ APKSSVEEIQ QLACSCFRLN SLQMAALLQQ
910 920 930 940 950
EKLPRNLVDT AIRMAESVAD ELTRADGREV RLEESPELHL ALLLPDDGFS
960 970 980 990 1000
CDVVRGIPTG LVDFLNPLQQ QGMCRLAAQP TSIGLWTVYM HQFNARSSSA
1010 1020 1030 1040 1050
MSNKLPQPEL QLIKLHKNSN GMGLSIVAAK GAGQEKLGIY IKSVVPGGAA
1060 1070 1080 1090 1100
DADGRLQAGD QLLRVDGQSL IGITQERAAD YLVRTGPVVS LEVAKQGAIY
1110 1120 1130 1140 1150
HGLATLLQQP SPVIQRGNRR MSERDLTRMG GAESTKSLGP LIANNHPNHS
1160 1170 1180 1190 1200
LSLSQHLNNS HNNTLGNSNN SSIINPLAAH LPNSKSVPAL HHHTGSGTIS
1210 1220 1230 1240 1250
LANSKSRSTH SLHNNTSGMG GIGGAAAGGM LGQPNGSQNN ANGNGNGNEQ
1260 1270 1280 1290 1300
GFYQNLSVYR AQNQSQPILN ERPPIAAHAA MNAYNGSSPL APQQQPQQQQ
1310 1320 1330 1340 1350
QSPYQQQQQQ QHMQANANLP PTRPVSAYYH SQQSAQQQLQ QQQQQQQQHS
1360 1370 1380 1390 1400
LQQQQFALSS GNLNGQQQQQ QQHQHQHQLT LNNRTKSQQN FQHTLRMQQM
1410 1420 1430 1440 1450
MAPSMPNISN MYHHQQQQQQ QLPLQQQQQQ QQQPLMSSSQ SMQNVNDFAG
1460 1470 1480 1490 1500
GYQNGSLEYR RSQLHDPSTL YEIQQQQLQQ QQQQQQQQQQ QQQASPNFIA
1510 1520 1530 1540 1550
LPPKPLGSLQ SPNKPNVPPS TAPKPQQDKP PLPPTATHPL FKATQQIAPG
1560 1570 1580 1590 1600
MNYVASTLDP PKGSYVASNQ GNNRPLHSGS NPWEREEREK DLEMRREHIR
1610 1620 1630 1640 1650
QWREQQISEL SQIVSRSPMQ EEQLKTLILE RDFERRAQEL QEQEEQDQEQ
1660 1670 1680 1690 1700
QYDKENVQEL FRLAGGGQVS AIQTPITSYR QTEIKLAEMP DSNSLVDSVP
1710 1720 1730 1740 1750
PQPPAPTAQP LSSNTQQPKS ILKHNRYSEG GVGPSGAPSS PSKSQKSASF
1760 1770 1780 1790 1800
ADERHLHTEH PISNLAKELN QLTMLDKDNN NETLDAVVPP PPPPERNSSY
1810 1820 1830 1840 1850
LIMSQQKLRG STGNATSSMG LLKTATSNQA AAAVEIKKAS LLNTQTNNNN
1860 1870 1880 1890 1900
NLSGSLNNNT MHGSPLSAME LNAAYVSATG TGIIGGLGTP PPPPPLMQRD
1910 1920 1930 1940 1950
NKRVSFHDEE NNFVSGNSQQ QQLQQQYIMD NYGMEHQDLD TIREDTSYLQ
1960 1970 1980 1990 2000
HNLDASMLPS MPATPDAALW NTSVQSTPGV IGAQEVYRDP RTRRLAEKQQ
2010 2020 2030 2040 2050
QQQQQRAGDA VPEKLSFKEK MKMFALESGE DKTPKDKLKI SRAQRDIDAV
H
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IPP4 | Q8IPP4_DROME | Canoe, isoform C | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,882 | Annotation score: | ||
A0A0B4KG43 | A0A0B4KG43_DROME | Canoe, isoform H | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,968 | Annotation score: | ||
A0A0B4KGI6 | A0A0B4KGI6_DROME | Canoe, isoform G | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,951 | Annotation score: | ||
Q8IPP3 | Q8IPP3_DROME | Canoe, isoform D | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,817 | Annotation score: | ||
A0A0B4KF82 | A0A0B4KF82_DROME | Canoe, isoform I | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,818 | Annotation score: | ||
A0A0B4KFK9 | A0A0B4KFK9_DROME | Canoe, isoform F | cno AF-6, anon-WO0172774.47, Canoe, CG2534, CG31537 | 1,721 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF52067.2 BT044227 mRNA Translation: ACH92292.1 AE014297 Genomic DNA Translation: ALI30529.1 |
RefSeqi | NP_001303494.1, NM_001316565.1 NP_524232.2, NM_079508.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0300525; FBpp0289752; FBgn0259212 FBtr0347363; FBpp0312543; FBgn0259212 |
GeneIDi | 40620 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF52067.2 BT044227 mRNA Translation: ACH92292.1 AE014297 Genomic DNA Translation: ALI30529.1 |
RefSeqi | NP_001303494.1, NM_001316565.1 NP_524232.2, NM_079508.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9VN82, 3 interactors |
STRINGi | 7227.FBpp0289752 |
Genome annotation databases
EnsemblMetazoai | FBtr0300525; FBpp0289752; FBgn0259212 FBtr0347363; FBpp0312543; FBgn0259212 |
GeneIDi | 40620 |
Organism-specific databases
CTDi | 40620 |
FlyBasei | FBgn0259212, cno |
VEuPathDBi | VectorBase:FBgn0259212 |
Phylogenomic databases
eggNOGi | KOG1892, Eukaryota |
GeneTreei | ENSGT00940000155237 |
OrthoDBi | 117649at2759 |
Miscellaneous databases
BioGRID-ORCSi | 40620, 0 hits in 1 CRISPR screen |
ChiTaRSi | cno, fly |
GenomeRNAii | 40620 |
Gene expression databases
Bgeei | FBgn0259212, Expressed in embryo and 39 other tissues |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15471, Myo5p-like_CBD_afadin, 1 hit |
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR037977, CBD_Afadin IPR002710, Dilute_dom IPR000253, FHA_dom IPR001478, PDZ IPR036034, PDZ_sf IPR000159, RA_dom IPR008984, SMAD_FHA_dom_sf IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00498, FHA, 1 hit PF00595, PDZ, 1 hit PF00788, RA, 2 hits |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00240, FHA, 1 hit SM00228, PDZ, 1 hit SM00314, RA, 2 hits |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50106, PDZ, 1 hit PS50200, RA, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VN82_DROME | |
Accessioni | Q9VN82Primary (citable) accession number: Q9VN82 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |