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Entry version 165 (18 Sep 2019)
Sequence version 4 (30 Nov 2010)
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Protein
Submitted name:

Circadian trip, isoform A

Gene

ctrip

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SAAS annotation EC:2.3.2.26

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3107Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Circadian trip, isoform AImported
Submitted name:
Circadian trip, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ctripImported
Synonyms:CG14656Imported, CG17735Imported, CTRIPImported, Dmel\CG42574Imported, TRIP12Imported
ORF Names:CG42574Imported, Dmel_CG42574Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0260794 ctrip

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0260794 Expressed in 32 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0292914

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1396 – 1473WWEInterPro annotationAdd BLAST78
Domaini2841 – 3140HECTInterPro annotationAdd BLAST300

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 177DisorderedSequence analysisAdd BLAST177
Regioni211 – 575DisorderedSequence analysisAdd BLAST365
Regioni593 – 623DisorderedSequence analysisAdd BLAST31
Regioni662 – 688DisorderedSequence analysisAdd BLAST27
Regioni701 – 720DisorderedSequence analysisAdd BLAST20
Regioni743 – 794DisorderedSequence analysisAdd BLAST52
Regioni832 – 865DisorderedSequence analysisAdd BLAST34
Regioni879 – 903DisorderedSequence analysisAdd BLAST25
Regioni913 – 932DisorderedSequence analysisAdd BLAST20
Regioni951 – 1042DisorderedSequence analysisAdd BLAST92
Regioni1509 – 1531DisorderedSequence analysisAdd BLAST23
Regioni1661 – 1690DisorderedSequence analysisAdd BLAST30
Regioni1791 – 1814DisorderedSequence analysisAdd BLAST24
Regioni1833 – 2003DisorderedSequence analysisAdd BLAST171
Regioni2067 – 2094DisorderedSequence analysisAdd BLAST28
Regioni2417 – 2439DisorderedSequence analysisAdd BLAST23
Regioni2708 – 2755DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 55PolarSequence analysisAdd BLAST55
Compositional biasi73 – 120PolarSequence analysisAdd BLAST48
Compositional biasi129 – 174PolarSequence analysisAdd BLAST46
Compositional biasi219 – 268PolarSequence analysisAdd BLAST50
Compositional biasi314 – 363PolarSequence analysisAdd BLAST50
Compositional biasi394 – 416PolarSequence analysisAdd BLAST23
Compositional biasi419 – 441AcidicSequence analysisAdd BLAST23
Compositional biasi457 – 488AcidicSequence analysisAdd BLAST32
Compositional biasi503 – 544PolarSequence analysisAdd BLAST42
Compositional biasi561 – 575PolarSequence analysisAdd BLAST15
Compositional biasi663 – 688PolarSequence analysisAdd BLAST26
Compositional biasi966 – 1031PolarSequence analysisAdd BLAST66
Compositional biasi1833 – 1857PolarSequence analysisAdd BLAST25
Compositional biasi1905 – 1966PolarSequence analysisAdd BLAST62
Compositional biasi1967 – 1981BasicSequence analysisAdd BLAST15
Compositional biasi1983 – 2003PolarSequence analysisAdd BLAST21
Compositional biasi2072 – 2094PolarSequence analysisAdd BLAST23
Compositional biasi2417 – 2436PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0168 Eukaryota
KOG0170 Eukaryota
COG5021 LUCA

KEGG Orthology (KO)

More...
KOi
K10590

Database of Orthologous Groups

More...
OrthoDBi
34110at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632 HECT, 1 hit
PF02825 WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00678 WWE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839 SSF117839, 1 hit
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit
PS50918 WWE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9VN58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESVKSQSL SALTEGQHDD GGSTATSATL ANKTSGTNTT SASNHSSQRR
60 70 80 90 100
RNNNTNSNRN KSHHKNEKRN APATSGPAVS SSVDVVPATS TASATSTRRS
110 120 130 140 150
RSQGRHSSAA ALSSKESQIP KRSVGAIRSP SSPAFNSIPV VSDQSLSPGS
160 170 180 190 200
RKRQLNQHNN SNNKASSSHQ SAPGGDQLVC APLKKRRLQQ SLGSGICEGA
210 220 230 240 250
VEINLGAASF DHTPRQASGD CVAQRTRSKT ISPEELPSTS SAAAARHHQI
260 270 280 290 300
RPSASSTSFS SSHRNKRKAS IGGSIAAVET TPHRGTAAAR AGRSGNLLNY
310 320 330 340 350
YRKTRKVSHT RSSQKSEKQS IPAEDTTANR NGSAGSGSSS KSGVIPKNRK
360 370 380 390 400
SLRHSQQNLL DTEAAEVESA AAETGGEQQS EHGNLDVIDQ LPTPEAGPNQ
410 420 430 440 450
SEASGIHNQS QLEADRQPVV QDEDDEEDDE EEEEEEEEEV GFYGIVNSAG
460 470 480 490 500
SSYEEDTQIV AEEDEITTEE EVDDEDDDEI EEEDLSESEF AQQLIGELGG
510 520 530 540 550
ERQQPQRATN NAKKTKNNTP AVAAASTIKA TTTATTSSGY QQRAAPHGQG
560 570 580 590 600
AAPGAGGGGP RATRSSNSNS SNNVVDYSIM PHLTTVATTT PHALTPQQHQ
610 620 630 640 650
QQRQPPQPPS HQQQQVHQQQ QPPQLLPTHQ FAHLSSFVTP TAAAAAAAAA
660 670 680 690 700
AHYPPASAAA AYFAQQQHHQ HQHQHQQQHV QQAQAPQPHY YHSSVAVLHQ
710 720 730 740 750
PPPHHFTSTG AGPPPALFQQ QAPPQLTRYT PATATTAATF VPPQQQQVVY
760 770 780 790 800
NPQQQQHSSL RRSSRGKTGS CVSSAAAAQQ QQHHQQQQHS SAAAAVQQQL
810 820 830 840 850
LPPPGTYQYQ QVGGNTVVVA VRHQQQLQQQ QQQQQQLALH HQHQQQQHQQ
860 870 880 890 900
QQQQHQQQQH QQQQRATLVQ PGFLFSYRSN QPQQQQQPAQ QIHQGPKVTH
910 920 930 940 950
SSAASDALTY SLMAQQPPSG PPHAGGQQIT PGANSANLSI VAAALSAARD
960 970 980 990 1000
VGGGSDGGGS AGGATPATGA SASSVGNTSA VGASSSSNSS AGQAASSNSN
1010 1020 1030 1040 1050
NVTATGSGSA PGGGPTSTGT TSGTQHGSGS GAAAAVDSES DDSEVGRLQA
1060 1070 1080 1090 1100
LLEARGLPPH LFGALGPRVT HILHRTIGNS SSSKANQLLQ GLQSHDESQQ
1110 1120 1130 1140 1150
LQAAIEMCQM LVMGNEDTLA GFPIKQVVPA LIQLLRMEHN FDIMNNACRA
1160 1170 1180 1190 1200
LAYMLEALPR SSGTVVEAVP VFLEKLQVIQ CMDVAEQSLS ALEILSRRHN
1210 1220 1230 1240 1250
KAILQANGIS ACLTYLDFFS IVAQRAALAI AANCCLNMHP EEFHFVAESL
1260 1270 1280 1290 1300
PLLARLLSQQ DKKCIESVCS AFCRLVESFQ HDGQRLQQIA SPDLLKNCQQ
1310 1320 1330 1340 1350
LLLVTPAILN TGTFTAVVRM LSLMCCSCPD LAISLLRNDI AATLLYLLTG
1360 1370 1380 1390 1400
NAEPAAASAT HVELISRSPS ELYELTCLIG ELMPRLPLDG IFAVDSLLDR
1410 1420 1430 1440 1450
PTLNTQDQVH WQWRDDRGSW HNYSTIDSRL IEAANQSSED EISLSTFGRT
1460 1470 1480 1490 1500
YTVDFHAMQQ INEDTGTTRP VQRRLNHNYV APMSAGQDLT TTSAGSAAAG
1510 1520 1530 1540 1550
GASTSAAAAA ASSNNNNNNN NNPPGNSVNL NQVKRRPSLD ARIACLKEER
1560 1570 1580 1590 1600
GLAADFIKHI FNVLYEVYSS SAGPNVRYKC LRALLRMVYY ATPELLRQVL
1610 1620 1630 1640 1650
KYQLVSSHIA GMLGSNDLRI VVGALQMAEI LMRQLPDVFG THFRREGVIY
1660 1670 1680 1690 1700
QFTQLTDPNN PICANPSPKP LSATATPTAN AGGSQSAPAS ANSLQVNPFF
1710 1720 1730 1740 1750
MDSAPGLSSA STTPSSSKHQ SYSVKSFSHA MNALTASAKG TPSGALDATS
1760 1770 1780 1790 1800
SSTTAGGYNY SSSAPSSSSG APAAYFVTQQ GDPRQYVHFQ QPAVPAPPPQ
1810 1820 1830 1840 1850
QELLPSGVQQ QGQQVPQVIY QPHHQQPAHL VLASTSSGAA SSSSSSSSSS
1860 1870 1880 1890 1900
SASALQHKMT DMLKRKAPPK RKSQSGGRAK SRQEDAAVAP AGSGPGGAPP
1910 1920 1930 1940 1950
SSSGSAMHEL LSRATSLGSG NGGRSTPNSG GGSGSSKSRF NAGNSSNAGS
1960 1970 1980 1990 2000
SKSSFLASLN PARWGRQTHQ NHHHHHQQSQ QQHHGLSKDS GNSNSTGSGS
2010 2020 2030 2040 2050
GAGLAYTVSQ HGAGSGAGGL NAAAVAASIS KSISHANLLA AANRERARQW
2060 2070 2080 2090 2100
VREQAVDFVK RYTEQEAKRS KAASESGATQ SGSSGVGLSS TGNTPLSTAG
2110 2120 2130 2140 2150
STNVLERLSS ILFKLNGSYH DCLDALLELK TILLESDISP FEVNHSGLIK
2160 2170 2180 2190 2200
AMLNYMTSET GLVERDARLR SFMHVFAGLP LEPLLQNVGQ MPTIEPIAFG
2210 2220 2230 2240 2250
AFVAKLNGCV TQLEQFPVKV HDFPAGPGGR SNQSALRFFN THQLKCNLQR
2260 2270 2280 2290 2300
HPQCNNLRQW KGGTVKIDPL AMVQAIERYL VVRGYGGIRA DSDDDSEEDM
2310 2320 2330 2340 2350
DDNVAAVVLS QASFRHKLQF TIGDHVLPYN MTVYQAVKQF SPLVSEQPET
2360 2370 2380 2390 2400
DNESETLLGN ASIWVQQHTI HYRPVEEEVT SGAAAGAASS SSSCSSGVQK
2410 2420 2430 2440 2450
QQSSSSSASS CVNATSSCSS SSGVASGGGS LTKKAHKSSS KFMRKKTELW
2460 2470 2480 2490 2500
HEGIAPVVIS ALKPFLSSSL PADVVTVQDA SLDALCMLRV IHALNRHWDH
2510 2520 2530 2540 2550
LYGCVVRQNI IPQSDFIHPK IMAKANRQLQ DPLVIMTGNL PQWLPQIGMA
2560 2570 2580 2590 2600
CPFLFPFETR HLLFYATSFD RDRALQRLLD TTPDLNAAES SERVAPRLDR
2610 2620 2630 2640 2650
RKRAISRTEI LKQAEHILQD FGHSKALLEI QYENEVGTGL GPTLEFYALV
2660 2670 2680 2690 2700
SAELQRTDLG LWNGSDSYKQ NSVTIVDVVK ANSAVLHIED ALEATTTDQN
2710 2720 2730 2740 2750
TPAVAGASLV SSSTTTTTTT AQQHQHPPTR SSSRSHVLRS GAGQQPVEHS
2760 2770 2780 2790 2800
SSSAGANENA LNMVIAQQFS DTNSANPAAI DNPSSTTTAT TVVQHNTTTN
2810 2820 2830 2840 2850
NSSIITTTTT TSYVHAVHGL FPLPLGKSSK LPQMTKAKAK FKFLGKFMAK
2860 2870 2880 2890 2900
AVMDSRMLDL PFSLPFYRWL VSEEHSIGLA DLMRVAPEVQ NTLVRLQDLV
2910 2920 2930 2940 2950
RQREYILSDP NIDAMEKTEK IEQLDLDGCP IADLGLDFVL PGHANIELCR
2960 2970 2980 2990 3000
GGRDTPVTVH NLHQYISLVT YWFLIEGVQK QFEALREGFD SVFPIQRLRM
3010 3020 3030 3040 3050
FYPEELECVF CGSGSEQQHS RWEIKMLQES CRTDHGFHQD SQAIQYLYEI
3060 3070 3080 3090 3100
LASYNRDEQR AFLQFVTGSP RLPTGGFKAL TPPLTIVRKT LDENQNPNDY
3110 3120 3130 3140
LPSVMTCVNY LKLPDYSSRE VMRQKLKVAA NEGSMSFHLS
Length:3,140
Mass (Da):336,576
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i280F5C0E1C979B3C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4JCW5A0A0B4JCW5_DROME
Circadian trip, isoform J
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
2,929Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LGR2A0A0B4LGR2_DROME
Circadian trip, isoform K
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
3,111Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JCV6A0A0B4JCV6_DROME
Circadian trip, isoform E
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
2,930Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JD62A0A0B4JD62_DROME
Circadian trip, isoform I
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
2,736Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JDA1A0A0B4JDA1_DROME
Circadian trip, isoform F
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
3,139Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LGQ5A0A0B4LGQ5_DROME
Circadian trip, isoform L
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
2,901Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LHQ4A0A0B4LHQ4_DROME
Circadian trip, isoform M
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
2,708Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JDB5A0A0B4JDB5_DROME
Circadian trip, isoform C
ctrip CG14656, CG17735, CTRIP, Dmel\CG42574, TRIP12
2,737Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF52092.4
AE014297 Genomic DNA Translation: ADV37262.1

NCBI Reference Sequences

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RefSeqi
NP_001189170.1, NM_001202241.2
NP_649496.3, NM_141239.5

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
40596

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG42574

UCSC genome browser

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UCSCi
CG17735-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF52092.4
AE014297 Genomic DNA Translation: ADV37262.1
RefSeqiNP_001189170.1, NM_001202241.2
NP_649496.3, NM_141239.5

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0292914

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi40596
KEGGidme:Dmel_CG42574
UCSCiCG17735-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
40596
FlyBaseiFBgn0260794 ctrip

Phylogenomic databases

eggNOGiKOG0168 Eukaryota
KOG0170 Eukaryota
COG5021 LUCA
KOiK10590
OrthoDBi34110at2759

Enzyme and pathway databases

ReactomeiR-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
40596

Gene expression databases

BgeeiFBgn0260794 Expressed in 32 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf
PfamiView protein in Pfam
PF00632 HECT, 1 hit
PF02825 WWE, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00678 WWE, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
PS50918 WWE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VN58_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VN58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: September 18, 2019
This is version 165 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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