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Entry version 154 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

Coiled-coil domain-containing protein 39

Gene

Dmel\CG17387

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 39ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG17387Imported
Synonyms:CG17387-RAImported
ORF Names:CG17387Imported, Dmel_CG17387Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037276, CG17387

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037276, Expressed in testis and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9VN57, 11 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078520

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VN57

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni926 – 953DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili45 – 68Sequence analysisAdd BLAST24
Coiled coili108 – 135Sequence analysisAdd BLAST28
Coiled coili143 – 163Sequence analysisAdd BLAST21
Coiled coili185 – 205Sequence analysisAdd BLAST21
Coiled coili255 – 345Sequence analysisAdd BLAST91
Coiled coili360 – 415Sequence analysisAdd BLAST56
Coiled coili423 – 464Sequence analysisAdd BLAST42
Coiled coili492 – 526Sequence analysisAdd BLAST35
Coiled coili629 – 649Sequence analysisAdd BLAST21
Coiled coili693 – 720Sequence analysisAdd BLAST28
Coiled coili731 – 751Sequence analysisAdd BLAST21
Coiled coili787 – 832Sequence analysisAdd BLAST46
Coiled coili848 – 868Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi929 – 953PolarSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC39 family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QS0D, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_309333_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
AMEDGNK

Database of Orthologous Groups

More...
OrthoDBi
355514at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033290, CCDC39

The PANTHER Classification System

More...
PANTHERi
PTHR18962, PTHR18962, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VN57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNRTDDMKNA SLNDYKLEAM ASVGWAVDSD IPMASAENLA ILKELTALRA
60 70 80 90 100
LKLELQQHMN SLDEREMAVE RHTRNIEGTI QQNLTLYSSL KDDVIKEAHN
110 120 130 140 150
VQLVILERNK IKEDLRKNNK ELEEYTEYVK VTERKICQSK REIDELTSRI
160 170 180 190 200
KSAKTTLVEW TEAMEDGNKG YQLIEKYYLD DQQKARELNI KRQLLQADID
210 220 230 240 250
KRRKQVVLLY DEQMTLEKNL ERTACLYRSA HAERRQMVET WKSAVNQMTQ
260 270 280 290 300
REHDIQRSEI ECAELAQKAQ QTAQTYKEYD NQLTEVIENN RQVELAIESL
310 320 330 340 350
NEESSDMKNQ IQILIDATLL KEREIDGLRR ELENLSNRVH LQRMDNRSQM
360 370 380 390 400
KKRDEKAKEL ENFASVMEKV NARLKSVQNK ALNAEQRLQI LEEMMQAEET
410 420 430 440 450
ALRNLDKEQE KVNEMLYRTQ RQVIELQDEE KVLKVQNDSL NSNLAAINRN
460 470 480 490 500
QQQVNNELKR QTEIHYSLSF KCLEAERRLA EIKGLADDPE VEATNMARLN
510 520 530 540 550
TLEQEYEKLQ RLIATTEAQN KKLNYNMNNL VVQYNADEKE LEMVRFKIKE
560 570 580 590 600
AQVYCEGTVK RLRQIRYENS ELIVDLNMVK MRCSDLEVGI GGCEQGTYDL
610 620 630 640 650
EQHRLAFRRA IKDRTVELRS QEDVLLLKKK HLNEELSTLR ADLGERKKQI
660 670 680 690 700
EAMKARFELT AQLLGKNEDG SIMTSTQLKV VSAQERQMLA DEGDALNKKV
710 720 730 740 750
LKAEKEVVAL ENTLRQFDKS NDNYRKTFRS VDENSKDRER AELELKELEA
760 770 780 790 800
AYCRELEKLK VLRCKAQHYQ QKHAAQRAEE EDLISKIEKA KASRAEHSAV
810 820 830 840 850
LEKIERELDD QRMKLDRANR EIRTQLREIK ARPFSEEYLA QFERDLSLQE
860 870 880 890 900
LEARNTKALN MITDLANSDE SGTDIIGILL RKGIKLPMHL KRTCSRVSWN
910 920 930 940 950
SSSSGKSSQG QDTASYLNVK GKKFSCDGAS ARSSVSDMSS LKDDTSSTTS
960
HSGLSIISLE LPLPKKK
Length:967
Mass (Da):112,255
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i109A91FF6703E941
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF52093.1
BT133224 mRNA Translation: AFA28465.1

NCBI Reference Sequences

More...
RefSeqi
NP_649495.1, NM_141238.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078880; FBpp0078520; FBgn0037276

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17387

UCSC genome browser

More...
UCSCi
CG17387-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF52093.1
BT133224 mRNA Translation: AFA28465.1
RefSeqiNP_649495.1, NM_141238.2

3D structure databases

SMRiQ9VN57
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VN57, 11 interactors
STRINGi7227.FBpp0078520

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
40595

Genome annotation databases

EnsemblMetazoaiFBtr0078880; FBpp0078520; FBgn0037276
GeneIDi40595
KEGGidme:Dmel_CG17387
UCSCiCG17387-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0037276, CG17387

Phylogenomic databases

eggNOGiENOG502QS0D, Eukaryota
GeneTreeiENSGT00390000015010
HOGENOMiCLU_309333_0_0_1
OMAiAMEDGNK
OrthoDBi355514at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40595, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40595

Gene expression databases

BgeeiFBgn0037276, Expressed in testis and 20 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR033290, CCDC39
PANTHERiPTHR18962, PTHR18962, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VN57_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VN57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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