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Entry version 172 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Auxilin, isoform A

Gene

aux

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-432722 Golgi Associated Vesicle Biogenesis
R-DME-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Auxilin, isoform AImported
Submitted name:
Auxilin, isoform BImported
Submitted name:
SD05837pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:auxImported
Synonyms:anon-WO0118547.393Imported, AuxImported, AuxillinImported, auxillinImported, dAuxImported, Dmel\CG1107Imported, DNAJC6Imported, GAKImported
ORF Names:CG1107Imported, Dmel_CG1107Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037218 aux

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VMY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037218 Expressed in 10 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VMY8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078604

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VMY8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 329Protein kinaseInterPro annotationAdd BLAST280
Domaini403 – 577Phosphatase tensin-typeInterPro annotationAdd BLAST175
Domaini583 – 716C2 tensin-typeInterPro annotationAdd BLAST134
Domaini1098 – 1165JInterPro annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni717 – 736DisorderedSequence analysisAdd BLAST20
Regioni756 – 833DisorderedSequence analysisAdd BLAST78
Regioni940 – 1006DisorderedSequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi940 – 1001PolarSequence analysisAdd BLAST62

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0431 Eukaryota
KOG1989 Eukaryota
KOG2283 Eukaryota
ENOG410Y515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167056

Identification of Orthologs from Complete Genome Data

More...
OMAi
PINLTVC

Database of Orthologous Groups

More...
OrthoDBi
826336at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06257 DnaJ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR011009 Kinase-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00226 DnaJ, 1 hit
PF00069 Pkinase, 1 hit
PF10409 PTEN_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01326 PTEN_C2, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565 SSF46565, 1 hit
SSF52799 SSF52799, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS50076 DNAJ_2, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9VMY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEFFKSLNL NYFSSSEVNG AAGNGAPEAL GGRLDNDFVG QVVEVAGHRL
60 70 80 90 100
RIKCVIAEGG YAFVYVAQDV QTGTEYALKR LIGADMQAST AIINEINIHK
110 120 130 140 150
QLSGHENIVA FVGSSYTAPS TQLGAQYLLL TELCKGGSLV DCFRTNNAPF
160 170 180 190 200
NPTCVLRIFY QMARAVASLH SQSPPIAHRD IKIENFLIGN DKQIKLCDFG
210 220 230 240 250
SASTEVLSPT FEWSANQRSM LEDQLNTVTT PMYRSPEMLD TWSNNPIGPK
260 270 280 290 300
VDIWALGCIL YFLCYRKHPY EDGGKLRIIN ANYMLPPDPQ YQCFSDIIRG
310 320 330 340 350
CLKVNPFERL DITMVLEGLA ALAETHNWSL KGPLDLHIMP IESLPAESPL
360 370 380 390 400
KSSAYSEVYT EPLSAAIPSS YNGHGSLLSS LRGGAGTLLK NIKDTSTKVM
410 420 430 440 450
QTMQQSLARN DLDISHITSR ILVMPCPSDG FESTYKTNNI EDVRLSLESR
460 470 480 490 500
FVPQKLSIYN FGQRTEPRLP PPVRTVEAGS VYGCPQAHAP NLQGLFTVSA
510 520 530 540 550
DMYNFLNADP KSVVIVQTGD SGGCTAATVI CALLMYADLL REPEDAVQVF
560 570 580 590 600
AVKRHTINLR PSEFRYLYYF GDILRPTPLL PHYKNTTLVS LSCQPVPRMT
610 620 630 640 650
KARDGCRIYM EVYCNGNLLL STLQDYEKMR LYQAGPGKIV LPINLTACGD
660 670 680 690 700
VTVVLFHARK GMVRPQGLKI CQFQFNTGFI PEPETLITFT NQDLDDLPDP
710 720 730 740 750
EQVTPRFCVS LSLAVTDSES PPSHKPPWMP AKPKRSPAAL FSSDLEYAEM
760 770 780 790 800
LDNFVTKPST RSSPPPGARK SDRVSSPLVL PDVTETAHEL PSPMPEPSPP
810 820 830 840 850
IDLLNLNQQP SDVPAADPLT SAKPSTDASF DLLGAFGDDD STGIGSAPIP
860 870 880 890 900
DILPPPPLQQ PQPKINNDPF DIFGSVDQGG VPSMKPSGFP PFVGSLPTFV
910 920 930 940 950
AQPAATTNPS PTHPARASAD PFANIADLAT GLNLNFNRST LSGKSPVNTS
960 970 980 990 1000
PQPTQFSSPT HKPSPSSQPQ ATFMHTPPTP QTLPSTSSIR TPTQPQAVPA
1010 1020 1030 1040 1050
QSRPDYSRLH FDSQKAAQQP GTGGSKNSDI FADILGQQGY SFGSKMNQCP
1060 1070 1080 1090 1100
RSINEMRKED LFKDMDPKKV RIMEWTDGKK NNIRALLCSM HTVLWDNAKW
1110 1120 1130 1140 1150
QRCEMSTMVT PTEVKKAYRR ACLAVHPDKH NGTENEEIAK LIFMELNNAW
1160
TDFENDATQQ NMFNA
Length:1,165
Mass (Da):127,924
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81EC7CD92093F2DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KG14A0A0B4KG14_DROME
Auxilin, isoform C
aux anon-WO0118547.393, Aux, Auxillin, auxillin, dAux
1,153Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KF57A0A0B4KF57_DROME
Auxilin, isoform D
aux anon-WO0118547.393, Aux, Auxillin, auxillin, dAux
1,157Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF52168.1
AE014297 Genomic DNA Translation: AAF52169.1
BT031027 mRNA Translation: ABV82409.1

NCBI Reference Sequences

More...
RefSeqi
NP_649438.1, NM_141181.3
NP_730785.1, NM_164317.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078965; FBpp0078604; FBgn0037218
FBtr0078966; FBpp0078605; FBgn0037218

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40527

UCSC genome browser

More...
UCSCi
CG1107-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF52168.1
AE014297 Genomic DNA Translation: AAF52169.1
BT031027 mRNA Translation: ABV82409.1
RefSeqiNP_649438.1, NM_141181.3
NP_730785.1, NM_164317.3

3D structure databases

SMRiQ9VMY8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0078604

Proteomic databases

PRIDEiQ9VMY8

Genome annotation databases

EnsemblMetazoaiFBtr0078965; FBpp0078604; FBgn0037218
FBtr0078966; FBpp0078605; FBgn0037218
GeneIDi40527
UCSCiCG1107-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40527
FlyBaseiFBgn0037218 aux

Phylogenomic databases

eggNOGiKOG0431 Eukaryota
KOG1989 Eukaryota
KOG2283 Eukaryota
ENOG410Y515 LUCA
GeneTreeiENSGT00940000167056
OMAiPINLTVC
OrthoDBi826336at2759

Enzyme and pathway databases

ReactomeiR-DME-432722 Golgi Associated Vesicle Biogenesis
R-DME-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40527

Gene expression databases

BgeeiFBgn0037218 Expressed in 10 organ(s), highest expression level in head
ExpressionAtlasiQ9VMY8 baseline and differential

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR011009 Kinase-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00069 Pkinase, 1 hit
PF10409 PTEN_C2, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52799 SSF52799, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS50076 DNAJ_2, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VMY8_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VMY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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