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Protein

60 kDa heat shock protein homolog 2, mitochondrial

Gene

Hsp60C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). Essential for proper development of trachea, spermatogonia and spermatocytes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: FlyBase
  • apoptotic mitochondrial changes Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • female germline ring canal formation Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • protein import into mitochondrial intermembrane space Source: GO_Central
  • protein refolding Source: InterPro
  • protein targeting to mitochondrion Source: FlyBase
  • spermatogenesis Source: FlyBase

Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Oogenesis, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa heat shock protein homolog 2, mitochondrial
Alternative name(s):
60 kDa chaperonin
CPN60
Heat shock protein 60
Short name:
HSP-60
Hsp60
Gene namesi
Name:Hsp60C
ORF Names:CG7235
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0031728 Hsp60C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Flies are male and female sterile; reduction in numbers of primary and secondary spermatocytes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 61MitochondrionBy similarityAdd BLAST61
ChainiPRO_000000503362 – 57660 kDa heat shock protein homolog 2, mitochondrialAdd BLAST515

Proteomic databases

PaxDbiQ9VMN5
PRIDEiQ9VMN5

Expressioni

Tissue specificityi

First detectable expression is seen in the posterior part of the dorsal tracheal trunk at stage 14-15, which marks the beginning of terminal tracheation. In the larval gut, expression in proventriculus is stronger than in midgut and hindgut. Malpighian tubules shows low expression and late third instar larval imaginal disks and brain showed moderate expression. In larval ovary and testis, expression is strong in the posterior region.1 Publication

Developmental stagei

Expression first seen in late embryonic stages and continues in larval and adult stages.1 Publication

Gene expression databases

BgeeiFBgn0031728
GenevisibleiQ9VMN5 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi59964, 15 interactors
DIPiDIP-20697N
IntActiQ9VMN5, 15 interactors
STRINGi7227.FBpp0078742

Structurei

3D structure databases

ProteinModelPortaliQ9VMN5
SMRiQ9VMN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00390000005727
InParanoidiQ9VMN5
KOiK04077
OMAiCVIKVGA
OrthoDBiEOG091G04JM
PhylomeDBiQ9VMN5

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VMN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRMFRYTNT LQRTAKISHV LWARNYAKDV RFGPEVRAMM LQGVDVLADA
60 70 80 90 100
VAVTMGPKGR NVIIEQSWGS PKITKDGVTV AKSIALKDKF QNIGAKLVQD
110 120 130 140 150
VANNTNEEAG DGTTTATVLA RAIAKEGFEK ISRGASPVEI RRGVMLAIET
160 170 180 190 200
VKDNLRRLSR PVNTPEEICQ VATISANGDK SVGNLISEAI KKVGRDGVIT
210 220 230 240 250
VKDGKTLCDE LEVIEGMKFD RGYISPYFIN TSKGAKVEFQ DALLLFCEKK
260 270 280 290 300
IKSAPSIVPA LELANAQRKP LVIIAEDLEA EALSTLVVNR LKVGLQVCAV
310 320 330 340 350
KAPGFGDNRK ENLMDMAVAT GGIVFGDEAN MVRLEDIKMS DFGRVGEVVV
360 370 380 390 400
SKDDTMLLKG KGQKAEVEKR VEGLREAIKE STSSYEKEKM QERLARLSSG
410 420 430 440 450
VALLRVGGSS DVEVSEKKDR VIDALNATRA AVEEGIVPGG GTALLRCIQK
460 470 480 490 500
LNDLKGANED QNMGIEIIRR ALRMPCLTIA KNAGVDGAMV VAKVEILDGD
510 520 530 540 550
YGYDALKGEY GNMIERGIID PTKVVRTAIS DAAGVASLLT TAEAVVTELP
560 570
LEEAAAAGAA AGLGALGGMG MGGMGM
Length:576
Mass (Da):61,587
Last modified:May 10, 2004 - v2
Checksum:i7FB52C049E9A5F79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160R → Q in AAM29278 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52277.2
AE014134 Genomic DNA Translation: AAN10550.2
AE014134 Genomic DNA Translation: AAN10551.2
AY113273 mRNA Translation: AAM29278.1
BT001308 mRNA Translation: AAN71063.1
RefSeqiNP_608948.2, NM_135104.5
NP_723104.2, NM_164654.2
NP_723105.2, NM_164655.3
UniGeneiDm.6406

Genome annotation databases

EnsemblMetazoaiFBtr0079110; FBpp0078742; FBgn0031728
FBtr0079111; FBpp0078743; FBgn0031728
FBtr0079112; FBpp0078744; FBgn0031728
GeneIDi33796
KEGGidme:Dmel_CG7235
UCSCiCG7235-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCH60C_DROME
AccessioniPrimary (citable) accession number: Q9VMN5
Secondary accession number(s): A4V087, Q8IHD0, Q8MZB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2004
Last modified: July 18, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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