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Entry version 164 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Lysine-specific demethylase lid

Gene

lid

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry.

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Myc.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi637Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi640Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi725Iron; catalyticPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri448 – 498PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1293 – 1354PHD-type 2PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1753 – 1808PHD-type 3PROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Dioxygenase, Oxidoreductase
Biological processBiological rhythms, Transcription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.11.67, 1994
1.14.99.66, 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-specific demethylase lid (EC:1.14.11.673 Publications)
Alternative name(s):
Histone demethylase lid
Jumonji/ARID domain-containing protein lid
Protein little imaginal disks
Retinoblastoma-binding protein 2 homolog
[histone H3]-trimethyl-L-lysine(4) demethylase lidCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lid
ORF Names:CG9088
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0031759, lid

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi637H → A: Abolishes enzymatic activity; when associated with A-536. 1 Publication1
Mutagenesisi639E → A: Abolishes enzymatic activity; when associated with A-534. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002924211 – 1838Lysine-specific demethylase lidAdd BLAST1838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei323Phosphothreonine1 Publication1
Modified residuei1422Phosphoserine1 Publication1
Modified residuei1433Phosphoserine1 Publication1
Modified residuei1474Phosphoserine1 Publication1
Modified residuei1635Phosphoserine1 Publication1
Modified residuei1640Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VMJ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9VMJ7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VMJ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0031759, Expressed in embryo and 42 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VMJ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VMJ7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Myc.

Part of a complex containing Lid, Myc and Ash2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60002, 44 interactors

Database of interacting proteins

More...
DIPi
DIP-29330N

Protein interaction database and analysis system

More...
IntActi
Q9VMJ7, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9VMJ7

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297914

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11838
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q9VMJ7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VMJ7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini161 – 202JmjNPROSITE-ProRule annotationAdd BLAST42
Domaini226 – 316ARIDPROSITE-ProRule annotationAdd BLAST91
Domaini591 – 757JmjCPROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 150DisorderedSequence analysisAdd BLAST150
Regioni321 – 380DisorderedSequence analysisAdd BLAST60
Regioni416 – 437DisorderedSequence analysisAdd BLAST22
Regioni1401 – 1462DisorderedSequence analysisAdd BLAST62
Regioni1548 – 1751DisorderedSequence analysisAdd BLAST204
Regioni1814 – 1838DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili960 – 1049Sequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 77Polar residuesSequence analysisAdd BLAST77
Compositional biasi101 – 119Polar residuesSequence analysisAdd BLAST19
Compositional biasi130 – 144Polar residuesSequence analysisAdd BLAST15
Compositional biasi354 – 380Polar residuesSequence analysisAdd BLAST27
Compositional biasi416 – 431Polar residuesSequence analysisAdd BLAST16
Compositional biasi1408 – 1423Polar residuesSequence analysisAdd BLAST16
Compositional biasi1548 – 1596Polar residuesSequence analysisAdd BLAST49
Compositional biasi1604 – 1624Polar residuesSequence analysisAdd BLAST21
Compositional biasi1650 – 1682Polar residuesSequence analysisAdd BLAST33
Compositional biasi1693 – 1743Polar residuesSequence analysisAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JARID1 histone demethylase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri448 – 498PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri1293 – 1354PHD-type 2PROSITE-ProRule annotationAdd BLAST62
Zinc fingeri1753 – 1808PHD-type 3PROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1246, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000991_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VMJ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWAPVAP

Database of Orthologous Groups

More...
OrthoDBi
664180at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VMJ7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.60, 1 hit
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR003347, JmjC_dom
IPR003349, JmjN
IPR013637, Lys_sp_deMease-like_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR004198, Znf_C5HC2
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01388, ARID, 1 hit
PF02373, JmjC, 1 hit
PF02375, JmjN, 1 hit
PF00628, PHD, 3 hits
PF08429, PLU-1, 1 hit
PF02928, zf-C5HC2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00501, BRIGHT, 1 hit
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit
SM00249, PHD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774, SSF46774, 1 hit
SSF57903, SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51011, ARID, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VMJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAKTEADNT TAANSGGGGV GSGTSSGGGA SANGTATPAR RLRTRNSTGN
60 70 80 90 100
GTNSGSESVK KSNANDEPST PVTPAGATGS HTHAPPGISP AVMERPMPSV
110 120 130 140 150
PMNHASSSVS ASKKYHNSCP HPTPTPAPTG HKKSVHTQPH SSNKFDQGKN
160 170 180 190 200
EEFHFDTPPE CPVFRPTTEE FKNPLAYISK IRSIAEKCGI AKILPPATWS
210 220 230 240 250
PPFAVDVDKL RFVPRVQRLN ELEAKTRVKL NFLDQIAKFW ELQGSSLKIP
260 270 280 290 300
MVERKALDLY TLHRIVQEEG GMEQTTKDRK WAKVANRMQY PSSKSVGATL
310 320 330 340 350
KAHYERILHP FEVYTSGKVL GPTPTSSGSG STPVKLEDGG GTDYKAHEIP
360 370 380 390 400
TRQQIAPPNE TNTRRSKRFG NSNASCGLSG VTPTTKPSAG VFVKTETKEE
410 420 430 440 450
FKRDLLSSFN AVNSGGSPLA TGTTANTRGA SQKKGGEPPA LIVDPLMKYI
460 470 480 490 500
CHICNRGDVE ESMLLCDGCD DSYHTFCLLP PLTSIPKGEW LCPRCVVEEV
510 520 530 540 550
SKPQEAFGFE QAEREYTLQQ FGQMADQFKQ EYFRKPVHLV PTEMVEREFW
560 570 580 590 600
RIVSSIDEDV TVEYGADLHT MDHGSGFPTK SSLYLLPGDQ EYAESSWNLN
610 620 630 640 650
NLPLLEDSIL GHINADISGM NAPWMYVGMC FAAFCWHNED HWSYSINYLH
660 670 680 690 700
WGEPKTWYGV PGSCAEQFEE TMKQAAPELF SSQPDLLHQL VTIMNPNILM
710 720 730 740 750
NNRVPVFRTD QHAGEFVITF PRAYHAGFNQ GYNFAEAVNF APADWLKMGR
760 770 780 790 800
ECVNHYSMLR RFCVFSHDEL VCKMALEPAK LTFGIATACY IDMAEMVDTE
810 820 830 840 850
KKLRKSLLEW GVTRAERRAF ELVNDDERHC QECNTTCFLS AVACECNDKL
860 870 880 890 900
IVCLRHYTVL CGCAPEKHTL IYRYTLDEMP LMLQKLKVKA HSFERWLSRC
910 920 930 940 950
RDIVDAHTPT SVTLQELQEL CKEAETKKFP SSLLIDRLNA AAVEAEKCVT
960 970 980 990 1000
VIQQLGINKV RTRSDHNQEA AQYKLTMEEL ELFVQEIDNL CCIIDEGASV
1010 1020 1030 1040 1050
RELLVLGKQF VERSESQLQL SLESLEESEL ETLINEGSSL RIELQQLDLL
1060 1070 1080 1090 1100
QKRLKQCKWY KRSQGLRETS SKLTYQDVKN LLHIAAADLD PTDPYVDKEM
1110 1120 1130 1140 1150
RKLQQIGADI EAWESQAAKY FRRLTQQHEL GEIEQFLKSA SDINGQVPSH
1160 1170 1180 1190 1200
GLLKDALRKA REWLRAVEQL QQNNHVTYCH TLEAMIERGL NIPIQLEELS
1210 1220 1230 1240 1250
RMQGHLNSAH QWKDNTACAF LKKGTFYTLL EVLMPRSDAI NIDSDLKPRF
1260 1270 1280 1290 1300
QDDFLKEKNP AEIVASFKHA EEQELLDMRE LRRQNMNKNP MRDMFCLCKS
1310 1320 1330 1340 1350
EFRNLMFNCQ LCRDWFHEDC VPPPSATNQN GIVNGGSGPG TNRPKWLCPS
1360 1370 1380 1390 1400
CVRSKRPRLE TILPLLVQLQ QLPIRLPEDE ALRCLAERAM NWQDRARKAL
1410 1420 1430 1440 1450
SSPDVSAAQE AIMAQQQQKR RSEGGAGVGN ISSPRKPRRR GSLTKEASGS
1460 1470 1480 1490 1500
TESDADDDDD EDECRLRIVE DNFSNDEDEP RTAPATSTVN SDLLKLLSDS
1510 1520 1530 1540 1550
EIENLLDLMM EGDLLEVSLD ETQELWRILE TMPPTLLQAE AMERVVQYMQ
1560 1570 1580 1590 1600
RQRQQHTNPL PTSGAEDSND SLMVQNSPNS NSNSGGATGS ASNSGRNKKR
1610 1620 1630 1640 1650
RSNDTGGNSA VPRKKQSTPK QTPGKKGSAA AARKSDAKAS PAASTTPGAD
1660 1670 1680 1690 1700
ADAENKQANG GNTNSSTGSG GGNSATTTPT PGSTHKKRKR TSTTATNNNN
1710 1720 1730 1740 1750
NNNNNSTNNS NSSTNLNSNT TSGQGAATGG NNATGGQKKH AQRSQQAAQE
1760 1770 1780 1790 1800
DDEEECRAEN CHKPTGREVD WVQCDGGCNE WFHMYCVGLN RSQIKPDDDY
1810 1820 1830
ICIRCTKTVA IGTQGSGHSM SVASTTTPGK QRAVQSAR
Length:1,838
Mass (Da):203,993
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE01BDB89027F9F50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NEV0M9NEV0_DROME
[Histone H3]-trimethyl-L-lysine(4) ...
Kdm5 dJARID1, dKDM5, Dmel\CG9088, KDM5, kdm5
1,838Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52319.1
AY095051 mRNA Translation: AAM11379.1
AE014134 Genomic DNA Translation: AAN10569.1

NCBI Reference Sequences

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RefSeqi
NP_001245908.1, NM_001258979.2
NP_001245909.1, NM_001258980.1
NP_001245910.1, NM_001258981.2
NP_001285649.1, NM_001298720.1
NP_523486.1, NM_078762.6
NP_723140.1, NM_164671.1

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0079231; FBpp0078862; FBgn0031759
FBtr0079232; FBpp0078863; FBgn0031759
FBtr0307069; FBpp0297912; FBgn0031759
FBtr0307070; FBpp0297913; FBgn0031759
FBtr0307071; FBpp0297914; FBgn0031759
FBtr0345336; FBpp0311492; FBgn0031759

Database of genes from NCBI RefSeq genomes

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GeneIDi
33837

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG9088

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52319.1
AY095051 mRNA Translation: AAM11379.1
AE014134 Genomic DNA Translation: AAN10569.1
RefSeqiNP_001245908.1, NM_001258979.2
NP_001245909.1, NM_001258980.1
NP_001245910.1, NM_001258981.2
NP_001285649.1, NM_001298720.1
NP_523486.1, NM_078762.6
NP_723140.1, NM_164671.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LM1NMR-A214-320[»]
2MIQNMR-A414-504[»]
BMRBiQ9VMJ7
SMRiQ9VMJ7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi60002, 44 interactors
DIPiDIP-29330N
IntActiQ9VMJ7, 11 interactors
MINTiQ9VMJ7
STRINGi7227.FBpp0297914

PTM databases

iPTMnetiQ9VMJ7

Proteomic databases

PaxDbiQ9VMJ7
PRIDEiQ9VMJ7

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
33837

Genome annotation databases

EnsemblMetazoaiFBtr0079231; FBpp0078862; FBgn0031759
FBtr0079232; FBpp0078863; FBgn0031759
FBtr0307069; FBpp0297912; FBgn0031759
FBtr0307070; FBpp0297913; FBgn0031759
FBtr0307071; FBpp0297914; FBgn0031759
FBtr0345336; FBpp0311492; FBgn0031759
GeneIDi33837
KEGGidme:Dmel_CG9088

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
33837
FlyBaseiFBgn0031759, lid

Phylogenomic databases

eggNOGiKOG1246, Eukaryota
GeneTreeiENSGT00940000168915
HOGENOMiCLU_000991_3_0_1
InParanoidiQ9VMJ7
OMAiKWAPVAP
OrthoDBi664180at2759
PhylomeDBiQ9VMJ7

Enzyme and pathway databases

BRENDAi1.14.11.67, 1994
1.14.99.66, 1994
ReactomeiR-DME-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
33837, 2 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33837

Protein Ontology

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PROi
PR:Q9VMJ7

Gene expression databases

BgeeiFBgn0031759, Expressed in embryo and 42 other tissues
ExpressionAtlasiQ9VMJ7, baseline and differential
GenevisibleiQ9VMJ7, DM

Family and domain databases

Gene3Di1.10.150.60, 1 hit
3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR003347, JmjC_dom
IPR003349, JmjN
IPR013637, Lys_sp_deMease-like_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR004198, Znf_C5HC2
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01388, ARID, 1 hit
PF02373, JmjC, 1 hit
PF02375, JmjN, 1 hit
PF00628, PHD, 3 hits
PF08429, PLU-1, 1 hit
PF02928, zf-C5HC2, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SM00558, JmjC, 1 hit
SM00545, JmjN, 1 hit
SM00249, PHD, 3 hits
SUPFAMiSSF46774, SSF46774, 1 hit
SSF57903, SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit
PS51184, JMJC, 1 hit
PS51183, JMJN, 1 hit
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDM5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VMJ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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