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UniProtKB - Q9VMA3 (CUP_DROME)

Entry version 163 (25 May 2022)
Sequence version 3 (07 Jul 2009)
Previous versions | rss
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Protein

Protein cup

Gene

cup

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos (PubMed:9118812).

Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation (PubMed:21937713).

Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G (PubMed:14685270, PubMed:15465908, PubMed:21081899).

This may contribute to translational repression but does not appear to be necessary for it to occur (PubMed:21081899).

Can promote translational repression independently of deadenylation and eIF4E1 binding (PubMed:21937713).

Required for correct localization of eIF4E1 in the developing oocyte (PubMed:15465908).

Required for translational repression of oskar (osk) mRNA (PubMed:14691132, PubMed:14723848).

Also required for the translational repression of nanos (nos) mRNA (PubMed:21081899).

Promotes the accumulation of the germ plasm components osk, vas and stau at the posterior pole of the oocyte and is required for germ cell development (PubMed:22454519, PubMed:17277377).

Represses orb positive autoregulatory activity which prevents premature activation of orb and ensures its accumulation specifically in the developing oocyte (PubMed:22164257).

In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934).

11 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Oogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9VMA3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein cup
Alternative name(s):
Oskar ribonucleoprotein complex 147 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cup
Synonyms:fs(2)cup
ORF Names:CG11181
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0000392, cup

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0000392

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mislocalization and precocious expression of orb in the ovary, accumulation of high levels of orb in nurse cells, elongation of orb poly-A tails, hyperphosphorylation of orb and reduced osk mRNA levels (PubMed:22164257). Reduced number of germ cells (PubMed:22454519).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi327Y → A: Strong reduction in interaction with eIF4E1. Strong reduction in interaction with eIF4E1; when associated with A-332 and A-348. Complete loss of interaction with eIF4E1; when associated with A-364 and A-368. 2 Publications1
Mutagenesisi332 – 333LM → AA: Reduction in interaction with eIF4E1. Strong reduction in interaction with eIF4E1; when associated with A-327. 1 Publication2
Mutagenesisi364L → A: Mild reduction in interaction with eIF4E1. Complete loss of interaction with eIF4E1; when associated with A-327 and A-368. 1 Publication1
Mutagenesisi368L → A: Mild reduction in interaction with eIF4E1. Complete loss of interaction with eIF4E1; when associated with A-327 and A-364. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000795611 – 1117Protein cupAdd BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263Phosphoserine1 Publication1
Modified residuei270Phosphoserine1 Publication1
Modified residuei347Phosphoserine1 Publication1
Modified residuei350Phosphoserine1 Publication1
Modified residuei503Phosphothreonine1 Publication1
Modified residuei509Phosphoserine1 Publication1
Modified residuei513Phosphoserine1 Publication1
Modified residuei520Phosphoserine1 Publication1
Modified residuei523Phosphoserine1 Publication1
Modified residuei524Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VMA3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9VMA3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in ovaries and in 0-2 hours old embryos. Weakly expressed in testis. Expressed in young embryos through stage 9, then it decreases throughout the rest of embryogenesis. In ovaries, it is expressed in germ cells throughout pre-vitellogenic development, but is not expressed in the somatic follicle cells. In germarial cysts, the protein (and not the transcripts) is transported selectively into the oocyte.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the egg chamber and more specifically in nurse cells (at protein level) (PubMed:17277377). Expressed during the first 2 hours of embryogenesis but is absent in 2-5 hour embryos (at protein level) (PubMed:28875934). Expressed both maternally and zygotically (PubMed:9118812). Expressed throughout embryogenesis (PubMed:22454519). In stage 2, uniformly distributed throughout the whole embryo (PubMed:22454519). During blastoderm formation, concentrated at the posterior pole to become incorporated into newly formed germ cells (PubMed:22454519). Subsequently accumulates specifically in the pole cells at stage 10, when they migrate through the posterior midgut primordium, and during stage 14, when the germ cells reach their final destination (PubMed:22454519).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0000392, Expressed in embryo and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VMA3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the osk RNP complex, which is composed of at least exu, yps, aret/bruno, cup, and the mRNA of osk (PubMed:10662770).

Interacts with the decapping activators me31B and tral (PubMed:21937713).

Component of the nos RNP complex, which is composed of at least smg, cup, tral, me31B, the CCR4-NOT complex members Rga/NOT2 and Caf1, and the mRNA of nos (PubMed:21081899).

Interacts with btz (PubMed:14691132, PubMed:14723848). Recruited to the 3'-UTR of nos and osk mRNAs by smg and btz, respectively (PubMed:14685270, PubMed:14691132).

Forms a ribonucleoprotein complex (RNP) containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934). No interaction was detected with pAbp in 1-5 hour embryos (PubMed:28875934).

Interacts with osk and vas (PubMed:22454519).

Interacts with Pop2, twin/CCR4, Rga, Not3 and Not1 which are all core components of the CCR4-NOT deadenylase complex; interaction with the complex is required for cup deadenylation activity (PubMed:21937713).

Interacts with nos (PubMed:11060247).

Interacts with smg (PubMed:14685270).

Interacts (via YXXXXLphi motifs) with eIF4E1; the interaction promotes retention of cup in the cytoplasm (PubMed:14723848, PubMed:14685270, PubMed:15465908, PubMed:21937713, PubMed:22832024).

Interacts with orb; the interaction represses the orb positive autoregulatory loop (PubMed:22164257).

Interacts with Nup154 (PubMed:17277377).

13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		60088, 64 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3177, eIF4E-cup complex

Database of interacting proteins

More...DIPi		DIP-17920N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9VMA3

Protein interaction database and analysis system

More...IntActi		Q9VMA3, 10 interactors

Molecular INTeraction database

More...MINTi		Q9VMA3

STRING: functional protein association networks

More...STRINGi		7227.FBpp0288761

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9VMA3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VMA3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 106DisorderedSequence analysisAdd BLAST106
Regioni270 – 326DisorderedSequence analysisAdd BLAST57
Regioni493 – 528DisorderedSequence analysisAdd BLAST36
Regioni596 – 618DisorderedSequence analysisAdd BLAST23
Regioni654 – 673DisorderedSequence analysisAdd BLAST20
Regioni679 – 728DisorderedSequence analysisAdd BLAST50
Regioni984 – 1004DisorderedSequence analysisAdd BLAST21
Regioni1016 – 1051DisorderedSequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi327 – 333YXXXXLphi motif 12 Publications7
Motifi363 – 369YXXXXLphi motif 21 Publication7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 66Pro residuesSequence analysisAdd BLAST16
Compositional biasi77 – 91Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi279 – 297Polar residuesSequence analysisAdd BLAST19
Compositional biasi493 – 517Polar residuesSequence analysisAdd BLAST25
Compositional biasi1023 – 1051Polar residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The YXXXXLphi motifs mediate interaction with eIF4E1.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 4E-T/EIF4E-T family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SXKW, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_278765_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VMA3

Identification of Orthologs from Complete Genome Data

More...OMAi		MGMSNNR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VMA3

Family and domain databases

Database of protein disorder

More...DisProti		DP01494

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50295

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018862, eIF4E-T

The PANTHER Classification System

More...PANTHERi		PTHR12269, PTHR12269, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10477, EIF4E-T, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VMA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQMAEAEQEN GAGALKIATN AGATDRPAHQ QLPLPVEDQQ DEVLTPAEKG 
        60         70         80         90        100
KFEYPPPPPP PTPVQAPLAT KATALNASQE HDDDEANSEK WEDPCAPPPP 
       110        120        130        140        150
PPLPTSAFLA TGLGYLKLPA FKLKDALEKA ITKLEANKRT LKASPESSRS 
       160        170        180        190        200
IKNKNVVALE MLPRRSNPET IGDGSMLAST STAVMLQTKK PAVIVEMERR 
       210        220        230        240        250
CKIINLLAKQ NQILESISGE AIPMHGPSKH LHEDEGLTLQ VLSARASTPY 
       260        270        280        290        300
TQPSSMLSCT AVSCDLEHDS PRKQVASKEA VPEQQSSQVQ QKRPPSTGIH 
       310        320        330        340        350
KPGSLRAPKA VRPTTAPVVS SKPVKSYTRS RLMDIRNGMF NALMHRSKES 
       360        370        380        390        400
FVMPRIATCD DIELEGRLRR MNIWRTSDGT RFRTRSTTAN LNMNNNNNNE 
       410        420        430        440        450
CMPAFFKNKN KPNLISDESI IQSQPPQPQT EFQDPAIVNQ RRIGSGRLNH 
       460        470        480        490        500
SKWGYNDEDY HSYHNGKSQH MEEVNSKNSK NMTVLQFFDN GEISSQPQRR 
       510        520        530        540        550
PNTPVMGMSI NRSENDTLHS NESSEDLSRA NENYVKRVMS GFLVVSKPKS 
       560        570        580        590        600
RDVEDRHHRR YRNQNEEPEW FSCGPTSRLD TIELCGFDED EEKMLKEGNK 
       610        620        630        640        650
NHGLGETERE TSKQKMDHKY KWTHAEPMGR SKYMPKHDTN NNHNVENMNN 
       660        670        680        690        700
VMATEHQQQK EEKRPGSGRS FQFDKFNQSQ QNYESSSYVN HQQPPQTQPQ 
       710        720        730        740        750
QMQQQSNTNT NNSKFMSFFA NEGNSSSSSL NEFFKQAINQ GHGNNPEQPK 
       760        770        780        790        800
SLGHIGQMPS VDQLEAKWRR NSLNNVGETA NKQTDNFQKL IGSLSSAKPQ 
       810        820        830        840        850
SQAVGYDAIS NFIMQQQQYQ QQQQKQHLII QQQQQHTAFL ASLQLKAILG 
       860        870        880        890        900
RADTQLLLLR LTKGEISKHG LLVQLANPRL TDMDREAITA VLQFTNTQQQ 
       910        920        930        940        950
QQQHKQQLDM LSSTVIASQL QNLHNLAIVQ QTLAARQQPQ HNPQTQAPHQ 
       960        970        980        990       1000
LSQEDLQAHA NVIMRNAVMK RKIEEQTSKL INGGAKHQAQ QQYLNRGQQR 
      1010       1020       1030       1040       1050
QARPDANSNA LLHALISGGG NNHASGYPMN GQPQKHHSNL RFGDNQNFQS 
      1060       1070       1080       1090       1100
FESNQPHFAT QYKQQYQQSQ QQHPHQQPQQ LNSLHQNNAG AVNSFNKAQM 
      1110 
QAQSAISMLP NSGDEFH
Length:1,117
Mass (Da):125,672
Last modified:July 7, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91274997F199EFD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2J9P9X2J9P9_DROME
Cup, isoform C
cup CUP, Cup, DmCup, Dmel\CG11181, fs(1)cup
1,117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB64427 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAL39852 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti836H → Q in AAB64427 (PubMed:9118812).Curated1
Sequence conflicti1030N → K in AAB64427 (PubMed:9118812).Curated1
Sequence conflicti1035K → Q in AAB64427 (PubMed:9118812).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF004917 mRNA Translation: AAB64427.1 Different initiation.
AE014134 Genomic DNA Translation: AAF52418.3
AY069707 mRNA Translation: AAL39852.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_001285687.1, NM_001298758.1
NP_523493.3, NM_078769.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0290322; FBpp0288761; FBgn0000392
FBtr0346452; FBpp0312102; FBgn0000392

Database of genes from NCBI RefSeq genomes

More...GeneIDi		33934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG11181

UCSC genome browser

More...UCSCi		CG11181-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004917 mRNA Translation: AAB64427.1 Different initiation.
AE014134 Genomic DNA Translation: AAF52418.3
AY069707 mRNA Translation: AAL39852.1 Different initiation.
RefSeqiNP_001285687.1, NM_001298758.1
NP_523493.3, NM_078769.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AXGX-ray2.80C/D296-425[»]
AlphaFoldDBiQ9VMA3
SMRiQ9VMA3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi60088, 64 interactors
ComplexPortaliCPX-3177, eIF4E-cup complex
DIPiDIP-17920N
ELMiQ9VMA3
IntActiQ9VMA3, 10 interactors
MINTiQ9VMA3
STRINGi7227.FBpp0288761

PTM databases

iPTMnetiQ9VMA3

Proteomic databases

PaxDbiQ9VMA3

Genome annotation databases

EnsemblMetazoaiFBtr0290322; FBpp0288761; FBgn0000392
FBtr0346452; FBpp0312102; FBgn0000392
GeneIDi33934
KEGGidme:Dmel_CG11181
UCSCiCG11181-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		33934
FlyBaseiFBgn0000392, cup
VEuPathDBiVectorBase:FBgn0000392

Phylogenomic databases

eggNOGiENOG502SXKW, Eukaryota
HOGENOMiCLU_278765_0_0_1
InParanoidiQ9VMA3
OMAiMGMSNNR
PhylomeDBiQ9VMA3

Enzyme and pathway databases

SignaLinkiQ9VMA3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		33934, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		cup, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		33934

Protein Ontology

More...PROi		PR:Q9VMA3

Gene expression databases

BgeeiFBgn0000392, Expressed in embryo and 21 other tissues
GenevisibleiQ9VMA3, DM

Family and domain databases

DisProtiDP01494
IDEALiIID50295
InterProiView protein in InterPro
IPR018862, eIF4E-T
PANTHERiPTHR12269, PTHR12269, 2 hits
PfamiView protein in Pfam
PF10477, EIF4E-T, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUP_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VMA3
Secondary accession number(s): O02432
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: July 7, 2009
Last modified: May 25, 2022
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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