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Entry version 121 (11 Dec 2019)
Sequence version 1 (01 May 2000)
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Protein

Polyprenol reductase

Gene

CG7840

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-193048 Androgen biosynthesis
R-DME-446199 Synthesis of Dolichyl-phosphate

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyprenol reductase (EC:1.3.1.94)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG7840
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0032014 CG7840

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003986541 – 326Polyprenol reductaseAdd BLAST326

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VLP9

PRoteomics IDEntifications database

More...
PRIDEi
Q9VLP9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0032014 Expressed in 25 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VLP9 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
60262, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9VLP9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VLP9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1640 Eukaryota
ENOG4111JQM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044920

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VLP9

KEGG Orthology (KO)

More...
KOi
K12345

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVPKRWF

Database of Orthologous Groups

More...
OrthoDBi
1574389at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VLP9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039698 Dfg10/SRD5A3

The PANTHER Classification System

More...
PANTHERi
PTHR14624 PTHR14624, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02544 Steroid_dh, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VLP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPENGILE VLENLLDRYK INLLQMMFGT FIATIVFFGG LMTFVEKYLP
60 70 80 90 100
NSIRQSFRYG KHSFKGETDP LVAWLEVPKS WFKHFYTFAL FWSWLAFYVL
110 120 130 140 150
VSTVREQKEA PEYVLQFLDI MGGGRSHRKV EIDSTTACVG AFMLTLQCTR
160 170 180 190 200
RFYETNFVQI FSKKSKINLS HYAVGYVHYF GAVIALLSNT SGFVRGSKPM
210 220 230 240 250
EFSLDKLTSQ QILYLGVFFL AWQQQYASNM ILVNLRKDPR TGSVKTEKHL
260 270 280 290 300
LPKGGLFNLL SSPHMFLEVV MYFCIADLYM PVRIWRLIFL WVASNQTINA
310 320
LLTHKWYQET FREYPKNRRA IIPFLL
Length:326
Mass (Da):38,034
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1DF380F2631AD90
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM52687 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti9L → P in strain: ZBMEL95 and ZBMEL157. 1
Natural varianti96A → V in strain: MEL11, ZBMEL145, ZBMEL131, ZBMEL229 and ZBMEL384. 1
Natural varianti125R → H in strain: MEL01, MEL02, MEL12, MEL13, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19, MEL20, ZBMEL84, ZBMEL95, ZBMEL131, ZBMEL157, ZBMEL191, ZBMEL377 and ZBMEL398. 1
Natural varianti239P → R in strain: ZBMEL186. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM294298 Genomic DNA Translation: CAL26216.1
AM294299 Genomic DNA Translation: CAL26217.1
AM294300 Genomic DNA Translation: CAL26218.1
AM294301 Genomic DNA Translation: CAL26219.1
AM294302 Genomic DNA Translation: CAL26220.1
AM294303 Genomic DNA Translation: CAL26221.1
AM294304 Genomic DNA Translation: CAL26230.1
AM294305 Genomic DNA Translation: CAL26235.1
AM294306 Genomic DNA Translation: CAL26236.1
AM294307 Genomic DNA Translation: CAL26237.1
AM294308 Genomic DNA Translation: CAL26238.1
FM245364 Genomic DNA Translation: CAR93290.1
FM245365 Genomic DNA Translation: CAR93291.1
FM245366 Genomic DNA Translation: CAR93292.1
FM245367 Genomic DNA Translation: CAR93293.1
FM245368 Genomic DNA Translation: CAR93294.1
FM245369 Genomic DNA Translation: CAR93295.1
FM245370 Genomic DNA Translation: CAR93296.1
FM245371 Genomic DNA Translation: CAR93297.1
FM245372 Genomic DNA Translation: CAR93298.1
FM245373 Genomic DNA Translation: CAR93299.1
FM245374 Genomic DNA Translation: CAR93300.1
FM245375 Genomic DNA Translation: CAR93301.1
AE014134 Genomic DNA Translation: AAF52635.1
AY122175 mRNA Translation: AAM52687.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_609203.1, NM_135359.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079598; FBpp0079218; FBgn0032014

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34136

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7840

UCSC genome browser

More...
UCSCi
CG7840-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM294298 Genomic DNA Translation: CAL26216.1
AM294299 Genomic DNA Translation: CAL26217.1
AM294300 Genomic DNA Translation: CAL26218.1
AM294301 Genomic DNA Translation: CAL26219.1
AM294302 Genomic DNA Translation: CAL26220.1
AM294303 Genomic DNA Translation: CAL26221.1
AM294304 Genomic DNA Translation: CAL26230.1
AM294305 Genomic DNA Translation: CAL26235.1
AM294306 Genomic DNA Translation: CAL26236.1
AM294307 Genomic DNA Translation: CAL26237.1
AM294308 Genomic DNA Translation: CAL26238.1
FM245364 Genomic DNA Translation: CAR93290.1
FM245365 Genomic DNA Translation: CAR93291.1
FM245366 Genomic DNA Translation: CAR93292.1
FM245367 Genomic DNA Translation: CAR93293.1
FM245368 Genomic DNA Translation: CAR93294.1
FM245369 Genomic DNA Translation: CAR93295.1
FM245370 Genomic DNA Translation: CAR93296.1
FM245371 Genomic DNA Translation: CAR93297.1
FM245372 Genomic DNA Translation: CAR93298.1
FM245373 Genomic DNA Translation: CAR93299.1
FM245374 Genomic DNA Translation: CAR93300.1
FM245375 Genomic DNA Translation: CAR93301.1
AE014134 Genomic DNA Translation: AAF52635.1
AY122175 mRNA Translation: AAM52687.1 Different initiation.
RefSeqiNP_609203.1, NM_135359.3

3D structure databases

SMRiQ9VLP9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi60262, 1 interactor
IntActiQ9VLP9, 1 interactor
STRINGi7227.FBpp0079218

Proteomic databases

PaxDbiQ9VLP9
PRIDEiQ9VLP9

Genome annotation databases

EnsemblMetazoaiFBtr0079598; FBpp0079218; FBgn0032014
GeneIDi34136
KEGGidme:Dmel_CG7840
UCSCiCG7840-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0032014 CG7840

Phylogenomic databases

eggNOGiKOG1640 Eukaryota
ENOG4111JQM LUCA
GeneTreeiENSGT00500000044920
InParanoidiQ9VLP9
KOiK12345
OMAiDVPKRWF
OrthoDBi1574389at2759
PhylomeDBiQ9VLP9

Enzyme and pathway databases

UniPathwayiUPA00378
ReactomeiR-DME-193048 Androgen biosynthesis
R-DME-446199 Synthesis of Dolichyl-phosphate

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34136

Protein Ontology

More...
PROi
PR:Q9VLP9

Gene expression databases

BgeeiFBgn0032014 Expressed in 25 organ(s), highest expression level in embryo
GenevisibleiQ9VLP9 DM

Family and domain databases

InterProiView protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039698 Dfg10/SRD5A3
PANTHERiPTHR14624 PTHR14624, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPORED_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VLP9
Secondary accession number(s): A0ANR0
, A0ANR1, A0ANR2, A0ANR3, A0ANR5, Q8MR21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 1, 2000
Last modified: December 11, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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