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Entry version 133 (26 Feb 2020)
Sequence version 3 (01 Oct 2002)
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Protein

Beta-alanine-activating enzyme

Gene

Aasdh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei411ATPBy similarity1
Binding sitei426ATPBy similarity1
Binding sitei516ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi177 – 185ATPBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-alanine-activating enzymeBy similarity (EC:6.2.1.-)
Alternative name(s):
Acyl-CoA synthetase family member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AasdhImported
Synonyms:U26Imported
ORF Names:CG13401Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0027780 Aasdh

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003158061 – 1012Beta-alanine-activating enzymeAdd BLAST1012

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VLL0

PRoteomics IDEntifications database

More...
PRIDEi
Q9VLL0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0027780 Expressed in embryo and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VLL0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VLL0 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088615

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1178 Eukaryota
KOG4649 Eukaryota
COG1520 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000033811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010423_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VLL0

KEGG Orthology (KO)

More...
KOi
K00142

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCIDDEQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VLL0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR025666 PQQ-like_dom
IPR018391 PQQ_beta_propeller_repeat
IPR002372 PQQ_repeat
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 1 hit
PF13360 PQQ_2, 1 hit
PF13570 PQQ_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00564 PQQ, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998 SSF50998, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VLL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPSDMDLIE STAEQPDKLY NINRIRAFKD VPFLIRRTES KDTIVSYADA
60 70 80 90 100
ADEIQVLMNF LRKNGVPDEA GIALRVTEHT PASSLMILAI LNNKCHFFPT
110 120 130 140 150
DKMMLSQDLY SQMSTAGVDY LVANKHLTVA PLYFTFLGSI LVFKEDCRLY
160 170 180 190 200
RVKLKSADET VQSKKPLPAN MCYTISTTGT TGKPKLIHVP YECIAPNIVG
210 220 230 240 250
LSQKLNVSMA DIIYLGTPIT FDPFVVEFFL ALQNGATLLT SRHSMRDSPS
260 270 280 290 300
KVLSALFPDN LATPGITVLQ MTPSLFRQFG ASSIKDRVLS GSSSLRVLLL
310 320 330 340 350
GGEPFPSNVE LVTWMHPSVL MQKHICNIYG ITEISCWSLL HIVQSLQSPV
360 370 380 390 400
PLGTPIEEDT VLRIESEDNE TSQQGELFLG SVKRRCYIPE VDDQANASQD
410 420 430 440 450
DSGICFRATG DLVTRQQDGT LFYSERSNDV VKRAGNRISL GLITRKIQKC
460 470 480 490 500
LPSSELTTCL WLEDLQKLIC CIRTLESKTR VQQRVQTFDI LSKVSIAEQP
510 520 530 540 550
DRFVYLQHFP CNVHGKLDKQ QLLKMCIPLA QPAQQILKSY LHDRLECVEE
560 570 580 590 600
PDDSASKKQR LDDAAPCGYD LSFRQAGGTS FHAITICREI GLQMCIDDEQ
610 620 630 640 650
RHLFEMLLDE NIPLRTVLRF LDTAKLVANN IKRKNVETAV VVSACQSGLI
660 670 680 690 700
IKRIEQPVLK LQIYWKVNFE KCIDSPVTEY EGRFICVGAH SKILRTLNPQ
710 720 730 740 750
TGSEYSVVKL PERIECKVTF LTEQLAMVGC YDGCLYGFNP QTGNIVFRVG
760 770 780 790 800
IGGLIKSQPM LTADGRRIIV CSYADDYNVY CLSAERQEVL WCLRIGEKPI
810 820 830 840 850
FASPLELPRE QSLIVCTLDG SYSRVAITDG SVEWTQKFRE PVFSTPVLLE
860 870 880 890 900
SVSNIFLSAE VAGRVHACHV GNGKILATFS TEGNIFSSLV VKTPPTFMGH
910 920 930 940 950
SFAIFGCIDQ HLYCLRCKTG PGGKSVELEL HWKVDVGAPI YATPTLLTVQ
960 970 980 990 1000
PNGLLVWCAA TDGRVMLINF RNGEIQWSDK LPGQVFSSAC FIEDLRRVFV
1010
GCRDNFLYCL GI
Length:1,012
Mass (Da):113,084
Last modified:October 1, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i765A7CA3EFF9B703
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2J591X2J591_DROME
Aminoadipate-semialdehyde dehydroge...
Aasdh Dmel\CG13401, U26, CG13401, Dmel_CG13401
323Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABE73255 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence CAB53510 differs from that shown. Insertion of a few bases causing frameshift at residue 295.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63K → M in ABE73255 (Ref. 4) Curated1
Sequence conflicti123A → V in ABE73255 (Ref. 4) Curated1
Sequence conflicti169A → G in ABE73255 (Ref. 4) Curated1
Sequence conflicti199V → M in ABE73255 (Ref. 4) Curated1
Sequence conflicti267T → S in ABE73255 (Ref. 4) Curated1
Sequence conflicti286D → E in ABE73255 (Ref. 4) Curated1
Sequence conflicti309V → D in ABE73255 (Ref. 4) Curated1
Sequence conflicti417Q → H in ABE73255 (Ref. 4) Curated1
Sequence conflicti424S → N in ABE73255 (Ref. 4) Curated1
Sequence conflicti638T → P in ABE73255 (Ref. 4) Curated1
Sequence conflicti642V → A in ABE73255 (Ref. 4) Curated1
Sequence conflicti744N → D in ABE73255 (Ref. 4) Curated1
Sequence conflicti912L → V in ABE73255 (Ref. 4) Curated1
Sequence conflicti970F → L in ABE73255 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ245708 mRNA Translation: CAB53510.1 Sequence problems.
AE014134 Genomic DNA Translation: AAF52679.3
BT025084 mRNA Translation: ABE73255.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_609230.2, NM_135386.5
NP_995660.2, NM_205938.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089673; FBpp0088615; FBgn0027780
FBtr0340243; FBpp0309217; FBgn0027780

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG13401

UCSC genome browser

More...
UCSCi
CG13401-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245708 mRNA Translation: CAB53510.1 Sequence problems.
AE014134 Genomic DNA Translation: AAF52679.3
BT025084 mRNA Translation: ABE73255.1 Sequence problems.
RefSeqiNP_609230.2, NM_135386.5
NP_995660.2, NM_205938.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0088615

Proteomic databases

PaxDbiQ9VLL0
PRIDEiQ9VLL0

Genome annotation databases

EnsemblMetazoaiFBtr0089673; FBpp0088615; FBgn0027780
FBtr0340243; FBpp0309217; FBgn0027780
GeneIDi34175
KEGGidme:Dmel_CG13401
UCSCiCG13401-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
132949
FlyBaseiFBgn0027780 Aasdh

Phylogenomic databases

eggNOGiKOG1178 Eukaryota
KOG4649 Eukaryota
COG1520 LUCA
GeneTreeiENSGT00440000033811
HOGENOMiCLU_010423_0_0_1
InParanoidiQ9VLL0
KOiK00142
OMAiMCIDDEQ
PhylomeDBiQ9VLL0

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34175

Protein Ontology

More...
PROi
PR:Q9VLL0

Gene expression databases

BgeeiFBgn0027780 Expressed in embryo and 24 other tissues
ExpressionAtlasiQ9VLL0 baseline and differential
GenevisibleiQ9VLL0 DM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR025666 PQQ-like_dom
IPR018391 PQQ_beta_propeller_repeat
IPR002372 PQQ_repeat
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13360 PQQ_2, 1 hit
PF13570 PQQ_3, 1 hit
SMARTiView protein in SMART
SM00564 PQQ, 5 hits
SUPFAMiSSF50998 SSF50998, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACSF4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VLL0
Secondary accession number(s): Q1RKX6, Q9U973
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: February 26, 2020
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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