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Protein

Alpha-(1,3)-fucosyltransferase B

Gene

FucTB

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase B (EC:2.4.1.-)
Alternative name(s):
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:FucTB
ORF Names:CG4435
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032117 FucTB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini28 – 444LumenalSequence analysisAdd BLAST417

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211271 – 444Alpha-(1,3)-fucosyltransferase BAdd BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9VLC1
PRIDEiQ9VLC1

Expressioni

Gene expression databases

BgeeiFBgn0032117
ExpressionAtlasiQ9VLC1 baseline and differential
GenevisibleiQ9VLC1 DM

Interactioni

Protein-protein interaction databases

BioGridi60364, 1 interactor
IntActiQ9VLC1, 1 interactor
STRINGi7227.FBpp0079411

Structurei

3D structure databases

ProteinModelPortaliQ9VLC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
InParanoidiQ9VLC1
KOiK09669
OMAiLYIQSDC
OrthoDBiEOG091G064Z
PhylomeDBiQ9VLC1

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR017176 Alpha-1_3-FUT_met
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit
PIRSFiPIRSF037332 Alpha1_3FUT_met, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VLC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLAQRYGIA LVALLMVGAT VLFFWSENII NYENIKFNSP VELVWWSRDM
60 70 80 90 100
SWNYDVQRQC GIHTCRITNK RSRRPWARGV LFYGSNIKTG DFPLPRNEHQ
110 120 130 140 150
IWALLHEESP RNTPFVSNKE FLRHFHFTST FSRYSNLPLT TMYLPSGEAL
160 170 180 190 200
TSKDYYVTFD GKSKYGYRPS TSVVFLQSDC DTMSGREDYV KELMKHLPID
210 220 230 240 250
SYGSCLRNRD LPESLQKDYL NNLYSPELLR FLSEYKFMIA IENAACPDYI
260 270 280 290 300
TEKFWRPLIM GVIPIYFGSP TIKDWEPNNK SAIFVNDFQN PQALVEYLNK
310 320 330 340 350
LADNKKLYNS YRQHKLNRRN PISNKKLLHN LVTRQYHIGD SSPGASLFEK
360 370 380 390 400
FECAVCYHVI NTARNVKADL RHYNCPLEPV YAKMEGQKIP QNVADWRAAM
410 420 430 440
EVGQCQAKVL DEFFRRDIGF NDAEFDAELN RRIEGNNCSN SSNT
Length:444
Mass (Da):51,801
Last modified:May 10, 2004 - v2
Checksum:i6D95748CA5EF2A76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti409V → I in CAC41642 (PubMed:11382750).Curated1
Sequence conflicti417D → N in CAC41642 (PubMed:11382750).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302046 mRNA Translation: CAC41642.1
AY061932 mRNA Translation: AAL31643.1
AE014134 Genomic DNA Translation: AAF52773.4
BT023506 mRNA Translation: AAY84906.1
RefSeqiNP_001285779.1, NM_001298850.1
NP_609288.4, NM_135444.5
UniGeneiDm.6605

Genome annotation databases

EnsemblMetazoaiFBtr0079811; FBpp0079411; FBgn0032117
FBtr0346623; FBpp0312203; FBgn0032117
GeneIDi34260
KEGGidme:Dmel_CG4435
UCSCiCG4435-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiFUCTB_DROME
AccessioniPrimary (citable) accession number: Q9VLC1
Secondary accession number(s): Q4QQB0, Q8I928
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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