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Entry version 138 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

Vacuolar protein sorting-associated protein 54

Gene

scat

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in retrograde transport from early and late endosomes to late Golgi (By similarity).

Required during spermatogenesis for sperm individualization.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • syntaxin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Protein transport, Spermatogenesis, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 54
Alternative name(s):
Protein scattered
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scat
ORF Names:CG3766
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011232, scat

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0011232

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001487361 – 940Vacuolar protein sorting-associated protein 54Add BLAST940

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VLC0

PRoteomics IDEntifications database

More...
PRIDEi
Q9VLC0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VLC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0011232, Expressed in spermathecum and 55 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VLC0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
71064, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VLC0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079409

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VLC0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni192 – 218DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili299 – 325Sequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS54 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2115, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000583

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005185_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VLC0

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSFVQSY

Database of Orthologous Groups

More...
OrthoDBi
449680at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VLC0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039745, Vps54
IPR012501, Vps54_C
IPR019515, VPS54_N

The PANTHER Classification System

More...
PANTHERi
PTHR12965, PTHR12965, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07928, Vps54, 1 hit
PF10475, Vps54_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VLC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATTRSAGGA ATSVDTGPAA GNSGIRKLST ASVGGIAGGV APSWQSCYYC
60 70 80 90 100
TREHFKSISD FVNHLRNRHC TREGGSFVCR YGFNGVCASL PLDGVSDRDY
110 120 130 140 150
DAHVAKYHVN QHTREMPPEW GVYSAAQNLP AVLNDPSRGK QSNLFTKKWG
160 170 180 190 200
EHFVERSHVP PSPRLPDITH ADFTVYLGSI GKRYRWHERR QQQLERDKPL
210 220 230 240 250
ENGAQGAPGP GTGGQTPTHL SSVPEIFLKS QLQLHHPATF KQVFPNYMQT
260 270 280 290 300
SASSPESHQQ TGRQLQEQLS HYLDMVEVKI AQQVSQKSAA FFHAMTTQHA
310 320 330 340 350
ILAEMEQAAD QVRQLRAALA ELHSHSVVDS FKVLRFAQRR QHYNLTLDKL
360 370 380 390 400
RLMATVHKTQ PMLQLLLGTQ DYVAALDLIG TTQEILSAEL LGIHCFKHLP
410 420 430 440 450
MQLSEMEKLI DKMLTTEFER YAAADLNRPL TDALRETDSV CAEEDKLVAI
460 470 480 490 500
VMGLLRKQNF SFVQAYQQEA IATIRAIIKQ LLIEVLARSD SDQEISLTGH
510 520 530 540 550
GEQALELTLP EWIALLQRSS QALVSILERI KTVVGIMQQT ADAAVGAQDA
560 570 580 590 600
VNLIDSEAFL SPGHHEQLKN QLQQLLQAVC HYCHERCANI VSPQSLERSS
610 620 630 640 650
ASEQELFQLS EIVDHFGETT RSICGVASVP LQLALKVQAS RYAQRFHSER
660 670 680 690 700
KQKLSLLLDQ ERWRQVDIPH EFQRIIERMA AGDYAKPEMG NLISNGAGNP
710 720 730 740 750
VLLVEGKQPY TLVSASLMLI RMLYEYGCSA HRLPLLASYH ARNVVDLLRC
760 770 780 790 800
FNSRSCQLII GAGAMRVAGL KTITSTNLAL VSRALQLVLW LLPKLKEHFQ
810 820 830 840 850
AMSGYETIER DYQGHIKEIE NKIHGIVSER LAAQLDAWEA RPPIPSQTFR
860 870 880 890 900
HISRHLVKLH EAIAGVLPEA QIHEIYGVVH RNFKDKLREQ LLKLNVNNNG
910 920 930 940
GPQHGVVTSE LTFYMETLRT LKALPAEQLD NGILEEIWLY
Length:940
Mass (Da):105,241
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i295D78EFE213AD62
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52774.1
AY061309 mRNA Translation: AAL28857.1

NCBI Reference Sequences

More...
RefSeqi
NP_524905.1, NM_080166.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079809; FBpp0079409; FBgn0011232

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
47942

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3766

UCSC genome browser

More...
UCSCi
CG3766-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52774.1
AY061309 mRNA Translation: AAL28857.1
RefSeqiNP_524905.1, NM_080166.4

3D structure databases

SMRiQ9VLC0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi71064, 2 interactors
IntActiQ9VLC0, 2 interactors
STRINGi7227.FBpp0079409

PTM databases

iPTMnetiQ9VLC0

Proteomic databases

PaxDbiQ9VLC0
PRIDEiQ9VLC0

Genome annotation databases

EnsemblMetazoaiFBtr0079809; FBpp0079409; FBgn0011232
GeneIDi47942
KEGGidme:Dmel_CG3766
UCSCiCG3766-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
47942
FlyBaseiFBgn0011232, scat
VEuPathDBiVectorBase:FBgn0011232

Phylogenomic databases

eggNOGiKOG2115, Eukaryota
GeneTreeiENSGT00390000000583
HOGENOMiCLU_005185_1_0_1
InParanoidiQ9VLC0
OMAiFSFVQSY
OrthoDBi449680at2759
PhylomeDBiQ9VLC0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
47942, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
47942

Protein Ontology

More...
PROi
PR:Q9VLC0

Gene expression databases

BgeeiFBgn0011232, Expressed in spermathecum and 55 other tissues
GenevisibleiQ9VLC0, DM

Family and domain databases

InterProiView protein in InterPro
IPR039745, Vps54
IPR012501, Vps54_C
IPR019515, VPS54_N
PANTHERiPTHR12965, PTHR12965, 1 hit
PfamiView protein in Pfam
PF07928, Vps54, 1 hit
PF10475, Vps54_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS54_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VLC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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