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Entry version 138 (12 Aug 2020)
Sequence version 4 (11 Jun 2014)
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Protein

Transcription factor glial cells missing 2

Gene

gcm2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor with a minor role promoting glial cell differentiation and a more significant role in hematocyte differentiation. Gcm2, together with gcm, is required for the proliferation of plasmatocyte precursors, the expression of Croquemort protein, and the ability of plasmatocytes to convert into macrophages.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi65 – 224GCMPROSITE-ProRule annotationAdd BLAST160

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor glial cells missing 2
Alternative name(s):
Protein glide-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gcm2
ORF Names:CG3858
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0019809, gcm2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001266531 – 606Transcription factor glial cells missing 2Add BLAST606

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VLA2

PRoteomics IDEntifications database

More...
PRIDEi
Q9VLA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in glial lineages within embryonic procephalic mesoderm. Expression is highest in hemocyte primordia and longitudinal and nerve root ganglia.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First appears in embryos, levels decrease in larvae and peak again in 1 day old pupae. No expression is found in adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0019809, Expressed in head mesoderm (Drosophila) and 18 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VLA2, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60379, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VLA2, 11 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0089223

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VLA2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi563 – 579Pro-richAdd BLAST17
Compositional biasi584 – 593His-rich10

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU2X, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006777

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031237_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VLA2

KEGG Orthology (KO)

More...
KOi
K21598

Identification of Orthologs from Complete Genome Data

More...
OMAi
WDINDAI

Database of Orthologous Groups

More...
OrthoDBi
722438at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.28.80, 1 hit
3.30.1370.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039791, GCM
IPR036115, GCM_dom_sf
IPR043020, GCM_large
IPR043021, GCM_small
IPR003902, Tscrpt_reg_GCM

The PANTHER Classification System

More...
PANTHERi
PTHR12414, PTHR12414, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03615, GCM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90073, SSF90073, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50807, GCM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VLA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVINGYSFK TQQLLTQQPD HSQLTQFVQP QSQSTHSVHP GPSPGQQQAG
60 70 80 90 100
GSMTMPSSST GKGKREWDIN DAIVPHVPDQ EFDEFNEWSD GHVRHIYSLH
110 120 130 140 150
NEEAKKHISG WAMRNTNNHN VNILKKSCLG VLVCSQHCTL PNGSKINLRP
160 170 180 190 200
AICDKARRKQ EGKACPNKSC RGGRLEIKPC RGHCGYPVTH FWRHSGNAIF
210 220 230 240 250
FQAKGVHDHL RPDPKNSSVS KRAFGRVPLA GKSANGSVAK KSVIAGLVKQ
260 270 280 290 300
AKQQHSLISK VLKRPAVSNP LAHTALDIYQ YNACGKCAGY SHCTCSYLDD
310 320 330 340 350
STTARSHQLS QSSNYGTNSW PLSGSESSAP CETAANVFTV NHQHITYNYP
360 370 380 390 400
IYHATPAAAT AAPSKSPSLP YACSISELAA YQQSSSGNSF AMGVPVHGHT
410 420 430 440 450
QCQAVAYDSS PQLATPEPEF INYSQIKHLG GGGGQEEISC KAEPGPTIKY
460 470 480 490 500
NATVETQPYV EDNYDYYYSP KAEYEMQQHH HQQQQSHQQF GGNQTAGHHY
510 520 530 540 550
YESSSGYNGV SYFDTGTTTA PGNTATGNGL EVGYGGYYDH YTSYEQQMAV
560 570 580 590 600
AGGFATAGGS TAPTVAAPPG HPPPPPPPPT LTYHHHHHHH LHHPAAATGL

APSVTH
Length:606
Mass (Da):65,674
Last modified:June 11, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5DF4B3C4ADE8478
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM22408 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32S → N in BAB83120 (Ref. 2) Curated1
Sequence conflicti37S → P in BAB83120 (Ref. 2) Curated1
Sequence conflicti37S → P in AAM22408 (PubMed:12167411).Curated1
Sequence conflicti41G → C in BAB83120 (Ref. 2) Curated1
Sequence conflicti50G → V in AAM22408 (PubMed:12167411).Curated1
Sequence conflicti60T → A in BAB83120 (Ref. 2) Curated1
Sequence conflicti288A → T in AAM22408 (PubMed:12167411).Curated1
Sequence conflicti301S → N in BAB83120 (Ref. 2) Curated1
Sequence conflicti433G → S in AAM22408 (PubMed:12167411).Curated1
Sequence conflicti489Q → E in AAM22408 (PubMed:12167411).Curated1
Sequence conflicti543S → N in BAB83120 (Ref. 2) Curated1
Sequence conflicti564T → A in BAB83120 (Ref. 2) Curated1
Sequence conflicti564T → A in AAM22408 (PubMed:12167411).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF184664 mRNA Translation: AAF74349.1
AB056467 mRNA Translation: BAB83120.1
AE014134 Genomic DNA Translation: AAF52793.2
BT022152 mRNA Translation: AAY51547.1
AF461416 mRNA Translation: AAM22408.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_609302.1, NM_135458.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079837; FBpp0079435; FBgn0019809

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34280

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184664 mRNA Translation: AAF74349.1
AB056467 mRNA Translation: BAB83120.1
AE014134 Genomic DNA Translation: AAF52793.2
BT022152 mRNA Translation: AAY51547.1
AF461416 mRNA Translation: AAM22408.1 Sequence problems.
RefSeqiNP_609302.1, NM_135458.5

3D structure databases

SMRiQ9VLA2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi60379, 22 interactors
IntActiQ9VLA2, 11 interactors
STRINGi7227.FBpp0089223

Proteomic databases

PaxDbiQ9VLA2
PRIDEiQ9VLA2

Genome annotation databases

EnsemblMetazoaiFBtr0079837; FBpp0079435; FBgn0019809
GeneIDi34280
KEGGidme:Dmel_CG3858

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9247
FlyBaseiFBgn0019809, gcm2

Phylogenomic databases

eggNOGiENOG502QU2X, Eukaryota
GeneTreeiENSGT00390000006777
HOGENOMiCLU_031237_0_0_1
InParanoidiQ9VLA2
KOiK21598
OMAiWDINDAI
OrthoDBi722438at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34280, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34280

Protein Ontology

More...
PROi
PR:Q9VLA2

Gene expression databases

BgeeiFBgn0019809, Expressed in head mesoderm (Drosophila) and 18 other tissues
GenevisibleiQ9VLA2, DM

Family and domain databases

Gene3Di2.20.28.80, 1 hit
3.30.1370.90, 1 hit
InterProiView protein in InterPro
IPR039791, GCM
IPR036115, GCM_dom_sf
IPR043020, GCM_large
IPR043021, GCM_small
IPR003902, Tscrpt_reg_GCM
PANTHERiPTHR12414, PTHR12414, 1 hit
PfamiView protein in Pfam
PF03615, GCM, 1 hit
SUPFAMiSSF90073, SSF90073, 1 hit
PROSITEiView protein in PROSITE
PS50807, GCM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCM2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VLA2
Secondary accession number(s): Q4V704
, Q8N012, Q8WST6, Q9NCQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 11, 2014
Last modified: August 12, 2020
This is version 138 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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