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Entry version 133 (17 Jun 2020)
Sequence version 3 (26 Jun 2013)
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Protein

Putative ATP-dependent RNA helicase SoYb

Gene

SoYb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in primary piRNA biogenesis in germline cells.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi521 – 528ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase SoYb (EC:3.6.4.13)
Alternative name(s):
Sister of Yb
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SoYb
ORF Names:CG31755
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0051755 SoYb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004252151 – 1476Putative ATP-dependent RNA helicase SoYbAdd BLAST1476

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VL52

PRoteomics IDEntifications database

More...
PRIDEi
Q9VL52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0051755 Expressed in embryo and 16 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VL52 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VL52 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60425, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VL52, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9VL52

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0292885

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VL52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 117Tudor 1Add BLAST110
Domaini502 – 649Helicase ATP-bindingAdd BLAST148
Domaini929 – 1043Tudor 2Add BLAST115
Domaini1317 – 1401CSAdd BLAST85

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi477 – 505Q motifAdd BLAST29
Motifi642 – 645DEAD box4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0331 Eukaryota
COG0513 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167250

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004169_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VL52

KEGG Orthology (KO)

More...
KOi
K18409

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLLNSCG

Database of Orthologous Groups

More...
OrthoDBi
85564at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VL52

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00567 TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51195 Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VL52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHQLDPDQE ESILITHFVN PHQFSYVRCI DVENSAMLVR QIEQDLKDYC
60 70 80 90 100
SSERTKQVYV EDERVIVRYQ RWSPPKLVRG VVRRRQNEEY LVWILDYGFN
110 120 130 140 150
LCCSVWDLWP LPDHLSRSLC DFKEGGVALI APHSGSVWSR SAIESLDKQL
160 170 180 190 200
EDANQLTFQV VHRGKSNRNF GLLKFRSSCQ TEDAANFLIK QDQGRCKETL
210 220 230 240 250
TMAIPYEDIS FEKAEINDMA IDTRPRLRRI LELVVLLSEN AKESTPTPSA
260 270 280 290 300
IQQKKLDALL QSHETYLIPN SVKLLSKVQS ISESSMQTAL ANRSKQISKE
310 320 330 340 350
LPHKANQSED NRKKEVKYLE SENLSECLSK VKLSSYQQKN TDSSTLSGPR
360 370 380 390 400
NLASSSTNSN SNVRKSMTLF KSSGAHLTTS LSVPLTENCT NQSNNRTVVF
410 420 430 440 450
SMDKMEQIFN DMLGKNPSER SVQKNRSQMP NSNVSTTKRC VEKMHVCRSE
460 470 480 490 500
NMGDRKPSVC LKHLVLAHSP EPVNPVTSYK ELPLGNTILN AMDDLNFQTP
510 520 530 540 550
LPTQIYAWPH LVNRGSLVLV NPSGTGRSWS YLPVICSSVL SSFENVTSNL
560 570 580 590 600
DTRIAPGPLA ILIVDSVENA KKLASHCEFL MKDFNTQNLK VVNTHAHSMM
610 620 630 640 650
DVYMMLLNSC GVLVTTLAHL NNILSNELPL VNPTRLEFII FDDYDRKRLD
660 670 680 690 700
NAELLKEVFQ KVNSIGGLSK QLVLVAQQWH SERFQKLLNR TTKPLILFGD
710 720 730 740 750
FLEAALYGGL KFNVTLRSSA LKARQLLDIL AEQDGSKKRT LIYCKNQMEL
760 770 780 790 800
EELSAILIEA GLQCVDISKA QNQSPNRLML VDDSQVRKQL PVRNIQLLIH
810 820 830 840 850
FSLPESWLRF SRRFHTMADN IRNLFTKPIG RGQDLITYIL MDENNAKEWP
860 870 880 890 900
RIMKFLQDHG LTTQSMPDSE QQLDNTLPYC PYKLSNGNCN RNQCNKRHHF
910 920 930 940 950
LKTDLPKIGN PLLQPGTLIR CKFLKAYDPA HMAVMPMKYK SKDSTIWIDV
960 970 980 990 1000
PYPSYPSTLV FKMSFGVPRK VHNPCKINDV CFVQHKELLS RVRIVDNPAR
1010 1020 1030 1040 1050
PQVTVQLMDY GTELLQVKAS QLLECPEQFR DLQQLAMDIR LSGLAGSGQG
1060 1070 1080 1090 1100
GMWSTDSIQW VQDRFADINE EIMQITVDFG VLDVAYVKEI ALIEECPTML
1110 1120 1130 1140 1150
TSVYKTFLRK ELLRQGFAKI DSTSILELRA IHEQWKQEME ELRANKENIV
1160 1170 1180 1190 1200
CSSTDLDNRD SKITSLQNKQ ATCSSGKEED LNPVETPLII ASPNSNETLE
1210 1220 1230 1240 1250
ERKHVSDKVQ NKIDELNDFN KSVEIEHVQD ASPLDSSTAL INTLIHELNT
1260 1270 1280 1290 1300
KSPTKKKNTQ EFIKNIVHED ETQSIHHEIS SSTNSLKQDK TIVVGPQDPP
1310 1320 1330 1340 1350
KELFLQYLNC ATKSRESVYP MVKWHQTLTH IELVVEQQML EYKLGLDGNT
1360 1370 1380 1390 1400
LEYKVNETTP PQRFILNLLG EVRIDSVKQH GYYLHIKLTK VGLLFHWPTL
1410 1420 1430 1440 1450
LNSLYVQKHA HWLIYDSERS HGPPPSFGLV LWEGYLTHKK TKSYSDSESS
1460 1470
EFSSTPEDFI EPGVEYCEMD SNLYED
Length:1,476
Mass (Da):168,480
Last modified:June 26, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94341F7A3C1103CB
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ADM35111 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52845.3
AE014134 Genomic DNA Translation: AFH03633.1
BT125632 mRNA Translation: ADM35111.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001245959.1, NM_001259030.2
NP_609335.3, NM_135491.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0303882; FBpp0292885; FBgn0051755
FBtr0308122; FBpp0300444; FBgn0051755

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34331

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG31755

UCSC genome browser

More...
UCSCi
CG31755-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52845.3
AE014134 Genomic DNA Translation: AFH03633.1
BT125632 mRNA Translation: ADM35111.1 Sequence problems.
RefSeqiNP_001245959.1, NM_001259030.2
NP_609335.3, NM_135491.5

3D structure databases

SMRiQ9VL52
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi60425, 10 interactors
IntActiQ9VL52, 6 interactors
MINTiQ9VL52
STRINGi7227.FBpp0292885

Proteomic databases

PaxDbiQ9VL52
PRIDEiQ9VL52

Genome annotation databases

EnsemblMetazoaiFBtr0303882; FBpp0292885; FBgn0051755
FBtr0308122; FBpp0300444; FBgn0051755
GeneIDi34331
KEGGidme:Dmel_CG31755
UCSCiCG31755-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34331
FlyBaseiFBgn0051755 SoYb

Phylogenomic databases

eggNOGiKOG0331 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00940000167250
HOGENOMiCLU_004169_0_0_1
InParanoidiQ9VL52
KOiK18409
OMAiMLLNSCG
OrthoDBi85564at2759
PhylomeDBiQ9VL52

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34331 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34331

Protein Ontology

More...
PROi
PR:Q9VL52

Gene expression databases

BgeeiFBgn0051755 Expressed in embryo and 16 other tissues
ExpressionAtlasiQ9VL52 baseline and differential
GenevisibleiQ9VL52 DM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
IPR002999 Tudor
PfamiView protein in Pfam
PF00567 TUDOR, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51195 Q_MOTIF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOYB_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VL52
Secondary accession number(s): E0R964
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: June 26, 2013
Last modified: June 17, 2020
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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