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Entry version 157 (17 Jun 2020)
Sequence version 4 (03 Mar 2009)
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Protein

ATP-binding cassette sub-family C member Sur

Gene

Sur

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.By similarity2 Publications

Miscellaneous

Drosophila is predominantly active around dawn and dusk, and has large sleep periods during the day and during night. Knockdown of Sur reduces sleep duration during the first half of the night, but has little effect on sleep during the day (PubMed:22105623).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi822 – 829ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1964 – 1971ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Receptor
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1296025 ATP sensitive Potassium channels
R-DME-382556 ABC-family proteins mediated transport
R-DME-422356 Regulation of insulin secretion
R-DME-5578775 Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family C member Sur
Alternative name(s):
Sulfonylurea receptor
Short name:
Dsur
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sur
ORF Names:CG5772
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0028675 Sur

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini58 – 71CytoplasmicSequence analysisAdd BLAST14
Transmembranei72 – 92Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini93 – 112ExtracellularSequence analysisAdd BLAST20
Transmembranei113 – 133Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini134 – 145CytoplasmicSequence analysisAdd BLAST12
Transmembranei146 – 166Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini167 – 182ExtracellularSequence analysisAdd BLAST16
Transmembranei183 – 203Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini204 – 224CytoplasmicSequence analysisAdd BLAST21
Transmembranei225 – 245Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini246 – 299ExtracellularSequence analysisAdd BLAST54
Transmembranei300 – 320Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini321 – 447CytoplasmicSequence analysisAdd BLAST127
Transmembranei448 – 468Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini469 – 474ExtracellularSequence analysis6
Transmembranei475 – 495Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini496 – 562CytoplasmicSequence analysisAdd BLAST67
Transmembranei563 – 583Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini584 – 600ExtracellularSequence analysisAdd BLAST17
Transmembranei601 – 621Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini622 – 1409CytoplasmicSequence analysisAdd BLAST788
Transmembranei1410 – 1430Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1431 – 1468ExtracellularSequence analysisAdd BLAST38
Transmembranei1469 – 1489Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1490 – 1558CytoplasmicSequence analysisAdd BLAST69
Transmembranei1559 – 1579Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1580 – 1655ExtracellularSequence analysisAdd BLAST76
Transmembranei1656 – 1676Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1677 – 1718CytoplasmicSequence analysisAdd BLAST42
Transmembranei1719 – 1739Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1740 – 2171ExtracellularSequence analysisAdd BLAST432

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004154151 – 2171ATP-binding cassette sub-family C member SurAdd BLAST2171

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VL32

PRoteomics IDEntifications database

More...
PRIDEi
Q9VL32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult heart. Detected at lower levels in head and abdomen.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0028675 Expressed in crop (Drosophila) and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VL32 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VL32 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60441, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9VL32, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0288707

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VL32

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini344 – 622ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini785 – 1014ABC transporter 1PROSITE-ProRule annotationAdd BLAST230
Domaini1421 – 1715ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST295
Domaini1930 – 2165ABC transporter 2PROSITE-ProRule annotationAdd BLAST236

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_27_8_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VL32

Identification of Orthologs from Complete Genome Data

More...
OMAi
HMTEDTL

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VL32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQLFNIIHC DHLNGHVRSI YDNLNTDICG IDRVRRVFTF FSIFLLLFGL
60 70 80 90 100
MFVCSRYKKC HKTLLTFHNG RAAISLLLLA LNSFDLARIF LPHQNVRNLN
110 120 130 140 150
RLFQSSPRDL NYLVVIGSGE LWNALFSTLL TLMLMLYHRM VERKKATVFL
160 170 180 190 200
YASTAVEALT FALLSNELFE LVRYEDFLEL QTCLVAMSAM CMVSLAMLDG
210 220 230 240 250
LTVYKECYHD DYLDDYGKIG YKHSMATFYS KSCFWWLTPL LWLGYKEPLE
260 270 280 290 300
LEDLGQMKLE DSARSHYDHF LYIYTEKKKK SNSSPSLWYC YIKNSWQMFA
310 320 330 340 350
LGGILKLAGD LFALIGPLAI QKIVEYIEQL YAQASEPPAK SPGNEVANVL
360 370 380 390 400
LSTSRILGTE FDEVFGTNID KGLIYRKSLL LNADGGCDSS DSAGQVQSTS
410 420 430 440 450
STSDEKQKND DSMATPEHVD NPSEPNISHD IGSITNHMTE DTRNIMEFFL
460 470 480 490 500
IIHYAWAIPF KIAVVIYLLY MNLGISAVIG SIACIVIMTP LQFFIGNAMS
510 520 530 540 550
KNAEVIAGYT DERLKRIHDT LVGIKVIKLN AWDEVFLKKI QEARRKELKY
560 570 580 590 600
LNKDATFWTL MAVLTHIATV LITFVTLGVY VWLHRDQEFD LNASRLFSSL
610 620 630 640 650
ALFQQLTVPL LIFPITVPII IAARVSTRRL ERFLKSSEIQ KQFEGIRNMA
660 670 680 690 700
RILSKSDASL DMYETQEKSN MTMRTAQAEN RLNEKRLAQK SQTPELATNS
710 720 730 740 750
TPLLQNAEES AEDISPSTVQ ELGHNKLVQQ RRELLRNTPY VAIRPPKMRG
760 770 780 790 800
SVMERPVEFS VIRARNTDSW RRDSLLLKMP DDIAVSINDG LFTWQPQSQM
810 820 830 840 850
PVVQLHVPGI IVPKGKLTIV VGKNGSGKTS LLSALLMEMP LLAGNMFWHK
860 870 880 890 900
TCTISYVSQQ PWLLNDTIRE NILFGESFRP KRYDFVLEAC ALKPDIELMP
910 920 930 940 950
RGDLSIIGER GINISGGQRQ RIAIARAIYS SANVVIMDDP LASLDNEVGE
960 970 980 990 1000
HIFQHCIREM LQKSNRTFIL VTQQLHRIKE AEYLIAIKDG RVEACGSYAD
1010 1020 1030 1040 1050
IELMQPRITA EWNAIIAMAK AKNDNPSQNP GEKTAGERWK LLKNVSKLGL
1060 1070 1080 1090 1100
QRSISVTMDA NVACHADAID GSGCISVANM QSNVVEEDDQ VSVSYPIGNA
1110 1120 1130 1140 1150
SCGGFNLQRK RSSIYGSRHL MYDVPLPIDE CQGDDVIMRP RRRHTLGRRG
1160 1170 1180 1190 1200
SRNTNSSHRL SGLSTLTATS ESSSISGDVL SRSVLATSCS SYAESSVDGG
1210 1220 1230 1240 1250
DLATAAPEPR VQSWQPPQHV THHQPLSRNA SSPPAMEVAN PDVKKSEEAR
1260 1270 1280 1290 1300
RSNTSSESPL DDHVRGSFQQ FLRRMSMRRS NKPKNHHHPL SATNSILSIS
1310 1320 1330 1340 1350
EESPPVVHFP ASILATDGNK NETQSEEKPK KCVNIDSKET TINCDDNCYS
1360 1370 1380 1390 1400
ASDKELRANV TSSPADQEQH NERHVLAEVA GESGRESMPL ARLAIDTERK
1410 1420 1430 1440 1450
YGKISDDIYL MYIRAAGLPI ITIFFITALI WQCLRVYTDI WLQQWSNVHG
1460 1470 1480 1490 1500
RVASKGHVVL HPSEQDHEVT YYFRMYAAIS CVCIIMALVS TPAGQYAGCN
1510 1520 1530 1540 1550
ARRNLHDKLL QTILHKTLHF FQVTPLGRIV NRFSNDMAVI DKKIAATGQR
1560 1570 1580 1590 1600
LLQFTLLCLS AILINVTITP WILVLTLPIC GAYYLIQKFY RCSARELQRI
1610 1620 1630 1640 1650
ENATNSPVIS HLSETIQGVT TIRAFNQQTR FTEILFKRLE ANTIAYALLN
1660 1670 1680 1690 1700
TSHRWLGVSL DYLGGCIVFV ATVTALTAAS VSCRRHYEAT TSPSASASPS
1710 1720 1730 1740 1750
PFETYAVTKS PSELRPSPSL VGLAINYTLL VPIYLNWVVK LLADMEMYAG
1760 1770 1780 1790 1800
SVERIAHYAQ GQDADADADA DADADVDADL DHEPSSNEDV SAEVDRSSQS
1810 1820 1830 1840 1850
DAGDKVYPGA TTAAGDVDED GDQQRIGGAR GGGGDCGYRQ GHENGAEANA
1860 1870 1880 1890 1900
DKLNAGNVTG DGNHLNFHHP PATAGDKVEQ ATTKTSVIKD KQLPPQQDDK
1910 1920 1930 1940 1950
DKKVVLPNEP ARKLERYQSV PISWPQRGDI HFDNVSLRYE GQKQNVISNL
1960 1970 1980 1990 2000
TLKIPAGQRI GICGRTGSGK SSLGLSLFGV LQTTRGHIYI DDVDIQRIRP
2010 2020 2030 2040 2050
DELRTRLSII PQDVHLFNAT IRENLDPHGY FQDLQLWNCL ELAQLKEFVN
2060 2070 2080 2090 2100
GHLPLGLDTV ICDGGLNLSA GHRQLLCLAR AILRGSVCLV LDEATSVLDS
2110 2120 2130 2140 2150
STESALLKAA DLAFRGRTII TIAHRLTTIL DYDRLIVLDQ GRIVEDGNPR
2160 2170
ELQQLEGSVF RGLLEKGASK W
Length:2,171
Mass (Da):242,375
Last modified:March 3, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BA7802AD742B6D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W5PZ45A0A1W5PZ45_DROME
Sulfonylurea receptor
Sur BEST:CK00325, CK00325, CYO, cyo, Dme_CG5772
2,223Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF06736 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34 – 35VR → CA in AAF06736 (PubMed:10506204).Curated2
Sequence conflicti54C → Y in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti77L → I in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti85D → E in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti413M → V in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti433S → G in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti444N → S in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti731R → G in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1022K → E in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1603A → T in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1757H → Q in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1763 – 1766Missing in AAF06736 (PubMed:10506204).Curated4
Sequence conflicti1772A → T in AAF06736 (PubMed:10506204).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF167431 mRNA Translation: AAF06736.1 Different initiation.
AE014134 Genomic DNA Translation: AAF52866.4

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

On The Other Side - Issue 139 of June 2012

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167431 mRNA Translation: AAF06736.1 Different initiation.
AE014134 Genomic DNA Translation: AAF52866.4

3D structure databases

SMRiQ9VL32
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi60441, 1 interactor
IntActiQ9VL32, 3 interactors
STRINGi7227.FBpp0288707

Proteomic databases

PaxDbiQ9VL32
PRIDEiQ9VL32

Organism-specific databases

FlyBaseiFBgn0028675 Sur

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
HOGENOMiCLU_000604_27_8_1
InParanoidiQ9VL32
OMAiHMTEDTL

Enzyme and pathway databases

ReactomeiR-DME-1296025 ATP sensitive Potassium channels
R-DME-382556 ABC-family proteins mediated transport
R-DME-422356 Regulation of insulin secretion
R-DME-5578775 Ion homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sur fly

Protein Ontology

More...
PROi
PR:Q9VL32

Gene expression databases

BgeeiFBgn0028675 Expressed in crop (Drosophila) and 26 other tissues
ExpressionAtlasiQ9VL32 baseline and differential
GenevisibleiQ9VL32 DM

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUR_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VL32
Secondary accession number(s): Q9U6Z2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 3, 2009
Last modified: June 17, 2020
This is version 157 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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