UniProtKB - Q9VKW5 (Q9VKW5_DROME)
Protein
Post-proline cleaving enzyme
Gene
Dmel\CG5355
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.ARBA annotation EC:3.4.21.26
GO - Molecular functioni
- carboxylic ester hydrolase activity Source: FlyBase
- endopeptidase activity Source: GO_Central
- oligopeptidase activity Source: GO_Central
- serine-type endopeptidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | HydrolaseImportedARBA annotation |
Protein family/group databases
ESTHERi | drome-CG5355, S9N_PPCE_Peptidase_S9 |
MEROPSi | S09.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Post-proline cleaving enzymeARBA annotation (EC:3.4.21.26ARBA annotation)Alternative name(s): Prolyl endopeptidaseARBA annotation |
Gene namesi | Name:Dmel\CG5355Imported ORF Names:CG5355Imported, Dmel_CG5355Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0032242, CG5355 |
Subcellular locationi
Interactioni
Protein-protein interaction databases
IntActi | Q9VKW5, 3 interactors |
STRINGi | 7227.FBpp0079637 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 465 | Peptidase_S9_NInterPro annotationAdd BLAST | 415 | |
Domaini | 539 – 750 | Peptidase_S9InterPro annotationAdd BLAST | 212 |
Sequence similaritiesi
Belongs to the peptidase S9A family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG2237, Eukaryota |
GeneTreei | ENSGT00530000063426 |
HOGENOMi | CLU_011290_1_1_1 |
OMAi | ACMTQRP |
OrthoDBi | 225446at2759 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002471, Pept_S9_AS IPR023302, Pept_S9A_N IPR001375, Peptidase_S9 IPR002470, Peptidase_S9A |
Pfami | View protein in Pfam PF00326, Peptidase_S9, 1 hit PF02897, Peptidase_S9_N, 1 hit |
PRINTSi | PR00862, PROLIGOPTASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00708, PRO_ENDOPEP_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VKW5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHTIFRGPLL YRRICQIVVP KTLPRNYIHR ELPSNLTRAM PSTLSAKLAY
60 70 80 90 100
PVARKDESVA EDFHGTQIKD VYRWLEDPDS TETEEFVNAQ NSISRPFLEN
110 120 130 140 150
GEEWKKLNTK LTKLWNYPKY GCPMRYGNYY YYFMNTGLQN QSVMYQQKSL
160 170 180 190 200
GDESESKVFL DPNTLSEDGT IALTQKAFSE DGKYMAYGLS ESGSDWIKIL
210 220 230 240 250
IRDAETGKDL SEVLEKVKFS EISWTKDNKG FFYGRYPDQD GKTDGSETKQ
260 270 280 290 300
NENQKLYYHR VGESQDKDTL VVEFPEEPSW RIQSTVSDCG KYLILAIVKD
310 320 330 340 350
CRDNIVFYAD LTPGAEITSK LNVKKIVEKF EADYDYITNE GSKIFFRTNK
360 370 380 390 400
NAPNYQVIAI DFNNSAEDKW ETLIAEHKSD VLDWVKCVDN DKLLVCYIRD
410 420 430 440 450
VKSVLQVNSL KDGTLLREFD LDIGTIVGTS GEKKYSEIFY NFSSFLNPGS
460 470 480 490 500
IYRYDFKTPD KSPSVFREIK LNLEGFRRED YAVEQIFYKS KDGTKVPMFI
510 520 530 540 550
IRKKRDSVEP RPCLLYGYGG FNISMLPSFG LSGLMFIDTF DGVLAYPNLR
560 570 580 590 600
GGGEYGEKWH NGGRLLNKQN VFDDFQAAAE YLIENKYTTK DRLAIQGGSN
610 620 630 640 650
GGLLVGSCIN QRPDLFGAAV AQVGVMDMLR FHKFTIGHAW CSDYGNPSEK
660 670 680 690 700
EHFDNLYKFS PLHNVHTPKG AETEYPSTLI LTADHDDRVS PLHSLKFIAA
710 720 730 740 750
LQEAVRDSEF QKNPVLLRVY QKAGHGAGKP TSKRIEEATD ILTFLSKSLN
VDIVNV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF52942.2 BT016072 mRNA Translation: AAV36957.1 |
RefSeqi | NP_609397.2, NM_135553.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0080047; FBpp0079637; FBgn0032242 |
GeneIDi | 34421 |
KEGGi | dme:Dmel_CG5355 |
UCSCi | CG5355-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF52942.2 BT016072 mRNA Translation: AAV36957.1 |
RefSeqi | NP_609397.2, NM_135553.4 |
3D structure databases
SMRi | Q9VKW5 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9VKW5, 3 interactors |
STRINGi | 7227.FBpp0079637 |
Protein family/group databases
ESTHERi | drome-CG5355, S9N_PPCE_Peptidase_S9 |
MEROPSi | S09.001 |
Proteomic databases
PRIDEi | Q9VKW5 |
Genome annotation databases
EnsemblMetazoai | FBtr0080047; FBpp0079637; FBgn0032242 |
GeneIDi | 34421 |
KEGGi | dme:Dmel_CG5355 |
UCSCi | CG5355-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0032242, CG5355 |
Phylogenomic databases
eggNOGi | KOG2237, Eukaryota |
GeneTreei | ENSGT00530000063426 |
HOGENOMi | CLU_011290_1_1_1 |
OMAi | ACMTQRP |
OrthoDBi | 225446at2759 |
Miscellaneous databases
BioGRID-ORCSi | 34421, 0 hits in 3 CRISPR screens |
ChiTaRSi | CG5355, fly |
GenomeRNAii | 34421 |
Gene expression databases
Bgeei | FBgn0032242, Expressed in embryo and 46 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002471, Pept_S9_AS IPR023302, Pept_S9A_N IPR001375, Peptidase_S9 IPR002470, Peptidase_S9A |
Pfami | View protein in Pfam PF00326, Peptidase_S9, 1 hit PF02897, Peptidase_S9_N, 1 hit |
PRINTSi | PR00862, PROLIGOPTASE |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00708, PRO_ENDOPEP_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9VKW5_DROME | |
Accessioni | Q9VKW5Primary (citable) accession number: Q9VKW5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |