Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 135 (13 Nov 2019)
Sequence version 2 (25 Nov 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Gamma-tubulin complex component 4 homolog

Gene

Grip75

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-tubulin complex component 4 homolog
Alternative name(s):
Gamma-ring complex protein 75 kDa
Short name:
d75p
Short name:
dGrip75
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Grip75
Synonyms:75p
ORF Names:CG6176
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0026431 Grip75

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781261 – 650Gamma-tubulin complex component 4 homologAdd BLAST650

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei214Phosphoserine1 Publication1
Modified residuei216Phosphothreonine1 Publication1
Modified residuei218Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VKU7

PRoteomics IDEntifications database

More...
PRIDEi
Q9VKU7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VKU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0026431 Expressed in 8 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VKU7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VKU7 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
60521, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VKU7, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9VKU7

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079623

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VKU7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2065 Eukaryota
ENOG410XPES LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VKU7

KEGG Orthology (KO)

More...
KOi
K16571

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEFFIKF

Database of Orthologous Groups

More...
OrthoDBi
1137416at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VKU7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.1900, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007259 GCP
IPR040457 GCP_C
IPR042241 GCP_C_sf
IPR041470 GCP_N

The PANTHER Classification System

More...
PANTHERi
PTHR19302 PTHR19302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VKU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIHDLLLACR SHNPEQLGIK AFNETTVIDQ FIHPCEREIF MDIIKIIKVY
60 70 80 90 100
QEVEQFTHSS GRKSDTHGEL PDSLHGYYLL NLAKGIEMAL EEYYAEIGRL
110 120 130 140 150
EKYCLGNERN SLSYVYNALY AKFPLLVFMR NLITEIHVLN LRGCVLLHNL
160 170 180 190 200
HQQCEHGDIQ LEKAIKIIMK PVKNAFFSSL AHWLLFGVID DVHSEFFIKF
210 220 230 240 250
TPTDAVDGSS FSKSATCSLL SAEKNPEDYI WQYEVNMSQL PGFFSIVLAE
260 270 280 290 300
KVLFVGQTVL VFKMGRNVKV KNKTDPLAAK LAELDSDDIY QLWSGRESEF
310 320 330 340 350
FKMVVDLSNE DTINVFRLEK VIIDIKNYVS ARLSEIAVNE VDLERQMGLI
360 370 380 390 400
KDFFLLGRGE FYLEFCSQMV GTMETYREER FKNVTRSFEL AATVTGITDD
410 420 430 440 450
LDKFSLICQR STSEPDDTSD FNFLQGLSLK YEYEWPLNLL FSPTTIERYN
460 470 480 490 500
NIFRFLLIIR TYQYEIQRVW AKQTWRAKSA KDVPPNNKII TLRNYLMFFL
510 520 530 540 550
NNMQYYIQVD VLESQFGILM NVIKSRSDFE VIQRAHTVFL ANVLSHCFLL
560 570 580 590 600
NESETQLNVT GSQNRNPIYG TLLKLFGICE KFAHMTQTKD PSDDLEDEVD
610 620 630 640 650
QLNESFGVQI ASLIQLLVDV KSASCLGPLS QLLLRLDFNC WFSASHNTSA
Length:650
Mass (Da):74,980
Last modified:November 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i515D8B36A80D08BE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52962.2
AJ249678 mRNA Translation: CAB62508.1

NCBI Reference Sequences

More...
RefSeqi
NP_609412.1, NM_135568.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080033; FBpp0079623; FBgn0026431

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34441

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6176

UCSC genome browser

More...
UCSCi
CG6176-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52962.2
AJ249678 mRNA Translation: CAB62508.1
RefSeqiNP_609412.1, NM_135568.4

3D structure databases

SMRiQ9VKU7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi60521, 8 interactors
IntActiQ9VKU7, 4 interactors
MINTiQ9VKU7
STRINGi7227.FBpp0079623

PTM databases

iPTMnetiQ9VKU7

Proteomic databases

PaxDbiQ9VKU7
PRIDEiQ9VKU7

Genome annotation databases

EnsemblMetazoaiFBtr0080033; FBpp0079623; FBgn0026431
GeneIDi34441
KEGGidme:Dmel_CG6176
UCSCiCG6176-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34441
FlyBaseiFBgn0026431 Grip75

Phylogenomic databases

eggNOGiKOG2065 Eukaryota
ENOG410XPES LUCA
InParanoidiQ9VKU7
KOiK16571
OMAiSEFFIKF
OrthoDBi1137416at2759
PhylomeDBiQ9VKU7

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34441

Protein Ontology

More...
PROi
PR:Q9VKU7

Gene expression databases

BgeeiFBgn0026431 Expressed in 8 organ(s), highest expression level in head
ExpressionAtlasiQ9VKU7 baseline and differential
GenevisibleiQ9VKU7 DM

Family and domain databases

Gene3Di1.20.120.1900, 1 hit
InterProiView protein in InterPro
IPR007259 GCP
IPR040457 GCP_C
IPR042241 GCP_C_sf
IPR041470 GCP_N
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 GCP_C_terminal, 1 hit
PF17681 GCP_N_terminal, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP4_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VKU7
Secondary accession number(s): Q9U1J7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: November 25, 2002
Last modified: November 13, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again