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Entry version 162 (12 Aug 2020)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

GH11711p

Gene

CG17093

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6809371, Formation of the cornified envelope

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
drome-CG17101, Acidic_Lipase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GH11711pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CG17093Imported
Synonyms:CG17101Imported, Dmel\CG31872Imported
ORF Names:CG31872Imported, Dmel_CG31872Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0051872, CG31872

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501510042224 – 1073Sequence analysisAdd BLAST1050

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0051872, Expressed in male reproductive gland and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VKT1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079688

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini717 – 767Abhydro_lipaseInterPro annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni176 – 365DisorderedSequence analysisAdd BLAST190
Regioni403 – 608DisorderedSequence analysisAdd BLAST206
Regioni637 – 696DisorderedSequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi239 – 331PolarSequence analysisAdd BLAST93
Compositional biasi340 – 365PolarSequence analysisAdd BLAST26
Compositional biasi403 – 423PolarSequence analysisAdd BLAST21
Compositional biasi434 – 492PolarSequence analysisAdd BLAST59
Compositional biasi506 – 608PolarSequence analysisAdd BLAST103
Compositional biasi637 – 672PolarSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.ARBA annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2624, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_287338_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHVQYQS

Database of Orthologous Groups

More...
OrthoDBi
651396at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR006693, AB_hydrolase_lipase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04083, Abhydro_lipase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VKT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLGFLYAFV ALLAIFRVEP SEGIIDINNQ LNNIISPPIL PAVESILDIN
60 70 80 90 100
GDADSTEDEQ KVRLQRESIV KDYGFVFKPQ PIVLESNSSY KPSVESEGQA
110 120 130 140 150
QSFSRGLEEA KLQIQKQSQS QSQAQGLGQS QQQIQYANIA RTKVQKQFQS
160 170 180 190 200
QQLGLAQSQQ QTQIQQSLNQ DGAKLREKPY PHIQTSSQRN ADDPESEEAE
210 220 230 240 250
APGGLSGKIA LVPPNEEGDQ KQDQAQSQIE DEAEVLRQGL AQTESQIQNQ
260 270 280 290 300
RQGLEKEIQG QSQSQDQAQS QDEAINPESA NAENRSSQQS GDVAENQDQA
310 320 330 340 350
ESQAQERSQL QLEGQEQSQD QAQSQDQSQA LEKGGAPPLS PQQSLVQAED
360 370 380 390 400
QAQEDPIDQS LHQAQSEVLN QVKSQTNGQL KAQAQMQAQV LDQALEDAHV
410 420 430 440 450
QYQSQAQSQG ISLSQTTQQS LVEPDDQAKE DPVDQSLHQA QSEIIKQLLS
460 470 480 490 500
QTNDQDKAQA QAQAQTLDQA LEEAHVQYQS QTQAQGTPIF QPPQLQPEDR
510 520 530 540 550
DQDTALDQSP TQAQLDAQSQ SQEQANTKLQ RKSQAQSEAH GIILTTLRKA
560 570 580 590 600
QAQQQSEVQS PQQEPLRSDD QSGDQAGDVA QNTALDQSLH QAQAEVQEQL
610 620 630 640 650
QSQTQASGTS LTQSQQQSQV QAVEALAQSL TQAHAQIQEQ AQSQSQSQEQ
660 670 680 690 700
DQSQSQAPNE RQSQLQSQRQ DQDQGPKFDD DLDEQPAPRS CSQCQKASYP
710 720 730 740 750
QYITEVDIEI DAKLDTPKMI SKYGHQAETH YAFTADGYKL CLHRIPRSGA
760 770 780 790 800
TPVLLVHGLM ASSDTWVQFG PSQGLAYILS QSGYDVWMLN TRGNVYSEER
810 820 830 840 850
LAGRESDKIF WDFSFHEIGQ YDLPAAIDLI LLQTKMPSIQ YIGHSQGSTA
860 870 880 890 900
FFVMCSERPE YAGKISLMQS LSPSVYMEGT RSPALKFMKV LQGGFTMLLN
910 920 930 940 950
LLGGHKISLK NRIVDMFRNH ICNKLIPSRI CAIFEFVVCG FNFNSFNMTL
960 970 980 990 1000
SPILEGHASQ GSSAKQIYHF AQLQGNSAFQ KYDYGLILNK IRYQSIFPPL
1010 1020 1030 1040 1050
YNLSLALGKV ALHRGDGDWL GSESDVLRLE RDLPNCIENR NIRFEGFSHF
1060 1070
DFTISKDVRS LVYDRVIDLC GSN
Length:1,073
Mass (Da):119,193
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE250E47628542DE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52979.2
AY118773 mRNA Translation: AAM50633.1
AE014134 Genomic DNA Translation: AHN54320.1

NCBI Reference Sequences

More...
RefSeqi
NP_001285806.1, NM_001298877.1
NP_723603.1, NM_164937.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080099; FBpp0079688; FBgn0051872
FBtr0345637; FBpp0311701; FBgn0051872

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG31872

UCSC genome browser

More...
UCSCi
CG31872-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52979.2
AY118773 mRNA Translation: AAM50633.1
AE014134 Genomic DNA Translation: AHN54320.1
RefSeqiNP_001285806.1, NM_001298877.1
NP_723603.1, NM_164937.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VKT1, 1 interactor
STRINGi7227.FBpp0079688

Protein family/group databases

ESTHERidrome-CG17101, Acidic_Lipase

Genome annotation databases

EnsemblMetazoaiFBtr0080099; FBpp0079688; FBgn0051872
FBtr0345637; FBpp0311701; FBgn0051872
GeneIDi34458
KEGGidme:Dmel_CG31872
UCSCiCG31872-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0051872, CG31872

Phylogenomic databases

eggNOGiKOG2624, Eukaryota
GeneTreeiENSGT00940000166317
HOGENOMiCLU_287338_0_0_1
OMAiAHVQYQS
OrthoDBi651396at2759

Enzyme and pathway databases

ReactomeiR-DME-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34458, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34458

Gene expression databases

BgeeiFBgn0051872, Expressed in male reproductive gland and 20 other tissues

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR006693, AB_hydrolase_lipase
PfamiView protein in Pfam
PF04083, Abhydro_lipase, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VKT1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VKT1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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