UniProtKB - Q9VKQ3 (WDR12_DROME)
Protein
Ribosome biogenesis protein WDR12 homolog
Gene
CG6724
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.UniRule annotation
GO - Molecular functioni
- ribonucleoprotein complex binding Source: UniProtKB-UniRule
GO - Biological processi
- maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB-UniRule
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
Keywordsi
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
Reactomei | R-DME-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-DME-8951664, Neddylation R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9VKQ3 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosome biogenesis protein WDR12 homologUniRule annotation |
Gene namesi | ORF Names:CG6724 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0032298, CG6724 |
Subcellular locationi
Nucleus
- nucleolus UniRule annotation
- nucleoplasm UniRule annotation
Cytosol
- cytosol Source: FlyBase
Nucleus
- nucleoplasm Source: UniProtKB-SubCell
- PeBoW complex Source: UniProtKB
Plasma Membrane
- plasma membrane Source: FlyBase
Other locations
- preribosome, large subunit precursor Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000369558 | 1 – 420 | Ribosome biogenesis protein WDR12 homologAdd BLAST | 420 |
Proteomic databases
PaxDbi | Q9VKQ3 |
Expressioni
Gene expression databases
Bgeei | FBgn0032298, Expressed in embryo and 47 other tissues |
ExpressionAtlasi | Q9VKQ3, baseline and differential |
Genevisiblei | Q9VKQ3, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 60562, 10 interactors |
IntActi | Q9VKQ3, 2 interactors |
STRINGi | 7227.FBpp0079780 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 104 – 142 | WD 1Add BLAST | 39 | |
Repeati | 143 – 185 | WD 2Add BLAST | 43 | |
Repeati | 192 – 231 | WD 3Add BLAST | 40 | |
Repeati | 250 – 288 | WD 4Add BLAST | 39 | |
Repeati | 290 – 329 | WD 5Add BLAST | 40 | |
Repeati | 335 – 375 | WD 6Add BLAST | 41 | |
Repeati | 379 – 417 | WD 7Add BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 10 – 92 | Ubiquitin-like (UBL) domainUniRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the WD repeat WDR12/YTM1 family.UniRule annotation
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0313, Eukaryota |
GeneTreei | ENSGT00930000150950 |
HOGENOMi | CLU_000288_57_0_1 |
InParanoidi | Q9VKQ3 |
OrthoDBi | 1540178at2759 |
PhylomeDBi | Q9VKQ3 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
HAMAPi | MF_03029, WDR12, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR012972, NLE IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR028599, WDR12/Ytm1 |
Pfami | View protein in Pfam PF08154, NLE, 1 hit PF00400, WD40, 4 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9VKQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVDNGEGQV QVHLKTKQEH YAVPDVPYAI DGTVTTVELN TFVNALLRQK
60 70 80 90 100
DGSSDTDFDF LVFDEYLRGR LCDHLREKAI SFEDAIEIEY VERFPAPEPQ
110 120 130 140 150
DCLLHDDWVS AVKARGKWIL SGCYDNTLNL WTNKGKHILT ISGHTAPIKA
160 170 180 190 200
VDWISLDEET GRFVSTSQDQ TAMLWQWNVG SNSVECVSVC KGHERGVDSV
210 220 230 240 250
SVSPDGLRFA TGSWDTMLKV WSAELDDAVE GSSKRMKESG VRTPKITLQG
260 270 280 290 300
HRESVSAVQW MDATTLLTGS WDHTLKVWDL SLEGIKTEIS TNKSIFDASY
310 320 330 340 350
SKLNRLILTA SADKNLRLYD PRTNQGSVVR NTYLGHNAWV QTVMWSTTEE
360 370 380 390 400
FLFVSGAYDN QNKLWDCRSP KAPLYDLLGH GEKVLDIDWS NPKYIVSGGV
410 420
DNTVRVFKSR KALAEEAETK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9PB96 | M9PB96_DROME | Ribosome biogenesis protein WDR12 h... | Dmel\CG6724 CG6724, Dmel_CG6724 | 418 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53009.1 AY118871 mRNA Translation: AAM50731.1 |
RefSeqi | NP_609452.1, NM_135608.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0080191; FBpp0079780; FBgn0032298 |
GeneIDi | 34488 |
KEGGi | dme:Dmel_CG6724 |
UCSCi | CG6724-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53009.1 AY118871 mRNA Translation: AAM50731.1 |
RefSeqi | NP_609452.1, NM_135608.3 |
3D structure databases
SMRi | Q9VKQ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 60562, 10 interactors |
IntActi | Q9VKQ3, 2 interactors |
STRINGi | 7227.FBpp0079780 |
Proteomic databases
PaxDbi | Q9VKQ3 |
Genome annotation databases
EnsemblMetazoai | FBtr0080191; FBpp0079780; FBgn0032298 |
GeneIDi | 34488 |
KEGGi | dme:Dmel_CG6724 |
UCSCi | CG6724-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0032298, CG6724 |
Phylogenomic databases
eggNOGi | KOG0313, Eukaryota |
GeneTreei | ENSGT00930000150950 |
HOGENOMi | CLU_000288_57_0_1 |
InParanoidi | Q9VKQ3 |
OrthoDBi | 1540178at2759 |
PhylomeDBi | Q9VKQ3 |
Enzyme and pathway databases
Reactomei | R-DME-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-DME-8951664, Neddylation R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9VKQ3 |
Miscellaneous databases
BioGRID-ORCSi | 34488, 0 hits in 1 CRISPR screen |
GenomeRNAii | 34488 |
PROi | PR:Q9VKQ3 |
Gene expression databases
Bgeei | FBgn0032298, Expressed in embryo and 47 other tissues |
ExpressionAtlasi | Q9VKQ3, baseline and differential |
Genevisiblei | Q9VKQ3, DM |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
HAMAPi | MF_03029, WDR12, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR012972, NLE IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf IPR028599, WDR12/Ytm1 |
Pfami | View protein in Pfam PF08154, NLE, 1 hit PF00400, WD40, 4 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR12_DROME | |
Accessioni | Q9VKQ3Primary (citable) accession number: Q9VKQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families