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Entry version 163 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

GH26960p

Gene

Porin2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPorinARBA annotation
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5205685, PINK1-PRKN Mediated Mitophagy
R-DME-5689880, Ub-specific processing proteases
R-DME-70268, Pyruvate metabolism

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.8.1.7, the mitochondrial and plastid porin (mpp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GH26960pImported
Submitted name:
Porin2, isoform AImported
Submitted name:
Porin2, isoform BImported
Submitted name:
Voltage-dependent anion-selective channel protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Porin2Imported
Synonyms:BEST:LP07660Imported, Dmel\CG17137Imported, DmPorin2Imported, LP07660.3primeImported, Porin 2Imported, porin 2Imported, Porin2 _z FBgn0069354Imported
ORF Names:CG17137Imported, Dmel_CG17137Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0069354, Porin2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9VKP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0069354, Expressed in testis and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079773

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VKP2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic mitochondrial porin family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane beta strandARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3126, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044399_2_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTERWNT

Database of Orthologous Groups

More...
OrthoDBi
938262at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07306, Porin3_VDAC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023614, Porin_dom_sf
IPR001925, Porin_Euk
IPR027246, Porin_Euk/Tom40

The PANTHER Classification System

More...
PANTHERi
PTHR11743, PTHR11743, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01459, Porin_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00185, EUKARYTPORIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VKP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAKTPTYPD LGKLARDLFK RGYHPGIWQI DCKTLTNSGI EFFTTGFASQ
60 70 80 90 100
DNSKVTGSLQ SKYKIEDQGL TLTERWNTEN WLFGEIMHRD KLAQGLMLAV
110 120 130 140 150
EAKFQPGSNE ADGKFKMGYA QDNFNFLADI GLNSEPILNC SLVVGHKEFL
160 170 180 190 200
GGVGTEFDVG NTELKGWKVA LGWTNETATL HGELKNGDTW LASLFYKASE
210 220 230 240 250
KIDAGIEVTK GAGGGEAAEG EQQGGDVVVN LGMIYHLEED ALVRAKVNNL
260 270 280 290
VELGLGYEQK LRDGITASIS AVLDCNNFKD GNHRFGVGIA LQC
Length:293
Mass (Da):31,936
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC92420CC6143DBD6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53020.1
AY118823 mRNA Translation: AAM50683.1
AE014134 Genomic DNA Translation: AGB92899.1
AJ580916 mRNA Translation: CAE45643.1

NCBI Reference Sequences

More...
RefSeqi
NP_001260364.1, NM_001273435.1
NP_609462.1, NM_135618.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080184; FBpp0079773; FBgn0069354
FBtr0332030; FBpp0304344; FBgn0069354

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17137

UCSC genome browser

More...
UCSCi
CG17137-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53020.1
AY118823 mRNA Translation: AAM50683.1
AE014134 Genomic DNA Translation: AGB92899.1
AJ580916 mRNA Translation: CAE45643.1
RefSeqiNP_001260364.1, NM_001273435.1
NP_609462.1, NM_135618.2

3D structure databases

SMRiQ9VKP2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079773

Protein family/group databases

TCDBi1.B.8.1.7, the mitochondrial and plastid porin (mpp) family

Proteomic databases

PRIDEiQ9VKP2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
34499

Genome annotation databases

EnsemblMetazoaiFBtr0080184; FBpp0079773; FBgn0069354
FBtr0332030; FBpp0304344; FBgn0069354
GeneIDi34499
KEGGidme:Dmel_CG17137
UCSCiCG17137-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34499
FlyBaseiFBgn0069354, Porin2

Phylogenomic databases

eggNOGiKOG3126, Eukaryota
GeneTreeiENSGT00950000182869
HOGENOMiCLU_044399_2_0_1
OMAiLTERWNT
OrthoDBi938262at2759

Enzyme and pathway databases

ReactomeiR-DME-5205685, PINK1-PRKN Mediated Mitophagy
R-DME-5689880, Ub-specific processing proteases
R-DME-70268, Pyruvate metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34499, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
porin, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34499

Gene expression databases

BgeeiFBgn0069354, Expressed in testis and 21 other tissues

Family and domain databases

CDDicd07306, Porin3_VDAC, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614, Porin_dom_sf
IPR001925, Porin_Euk
IPR027246, Porin_Euk/Tom40
PANTHERiPTHR11743, PTHR11743, 1 hit
PfamiView protein in Pfam
PF01459, Porin_3, 1 hit
PRINTSiPR00185, EUKARYTPORIN

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VKP2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VKP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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