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Entry version 132 (16 Jan 2019)
Sequence version 3 (18 Sep 2013)
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Protein

GATOR complex protein WDR59

Gene

CG4705

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the regulation of the TORC1 pathway by amino acids.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cellular response to amino acid starvation Source: UniProtKB
  • positive regulation of TOR signaling Source: UniProtKB

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9VKK2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GATOR complex protein WDR59Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG4705
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0032339 CG4705

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807241 – 969GATOR complex protein WDR59Add BLAST969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei373Phosphothreonine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VKK2

PRoteomics IDEntifications database

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PRIDEi
Q9VKK2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VKK2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0032339 Expressed in 28 organ(s), highest expression level in Malpighian tubule

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9VKK2 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
60602, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079785

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9VKK2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati127 – 167WD 1Add BLAST41
Repeati172 – 211WD 2Add BLAST40
Repeati215 – 255WD 3Add BLAST41
Repeati258 – 303WD 4Add BLAST46
Repeati307 – 351WD 5Add BLAST45
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini435 – 538RWDPROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0309 Eukaryota
COG2319 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157600

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VKK2

KEGG Orthology (KO)

More...
KOi
K20409

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQLCQGT

Database of Orthologous Groups

More...
OrthoDBi
590848at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VKK2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16692 mRING-H2-C3H3C2_WDR59, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006575 RWD-domain
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037591 WDR59
IPR039456 WDR59_mRING-H2-C3H3C2

The PANTHER Classification System

More...
PANTHERi
PTHR22850:SF116 PTHR22850:SF116, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50908 RWD, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VKK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPTETLRPG ERGTAGGPGA GAPEQTYIVR QSNKYYEHRD SQATAMSVDY
60 70 80 90 100
SGQWVLLAGR GHLALQRLGQ DDGSLRRHER QSKYEVSVAE FAICPSRKEY
110 120 130 140 150
CAIATSQHID IVRWGTAEPH YEMSLRGHTR TVTDIDWHGK DPNLLVSCSI
160 170 180 190 200
DTFSHIWDLR EPRKPALSLN AVCMSGATQV GFNRVSGNLL AAAHDGDLRI
210 220 230 240 250
WDIRKGSCPT HYITAHLNRV HGINWSHKRE TCLATASQDG TVKYFDVCNP
260 270 280 290 300
RRAEKIITTM SPVWRARYTP IGNGLVSIVV PHLGRGENSL LLWSNSKQTD
310 320 330 340 350
PICSFVGHTD VILDFAWRPN RESSNEIELV TWSRDRTLRV WKIDDNMLKL
360 370 380 390 400
CEPSAEEIES RFEPDLSELR VPTPPEFLHP RSILVAASLP ISTGDGACNT
410 420 430 440 450
LPMARSPSFG GGYYRREEPH IARSLTDQPT CSLHHEFSLL NTNMPHVEVD
460 470 480 490 500
TLDAIKRYAC FKICAGGHTV ILQVTFTTSY PSPSAPPDFQ LCQGTTLSSE
510 520 530 540 550
VSGVLLKVLR CNALQRVKKS RTCLEQCLRA LVAAMKKKVA AVGGADRSQL
560 570 580 590 600
LLQSPRLEGA LSSTLHDACI PYPRTSGVHF NAIGMLTTFA QPVNNKRLTL
610 620 630 640 650
RQHTALTPRT FSSINGSGLL GNVMATAQRE ANASFYLQER MISGKPGKQR
660 670 680 690 700
AIRQMNGSPV VHVYDTSSLL HISRRMAREF SLDKCNIAET CRKNGEICRQ
710 720 730 740 750
HGRLDLVPVW LLAELIATPQ IPHETLNDLL FYKDPFKKSL LESLIMHYAI
760 770 780 790 800
SGDIQTAVLL ACLFDKCPTG GGAIMEKTVR LPPQLNSQIS PYHTVLPLDV
810 820 830 840 850
KSSSSSNTWQ QLKQLRSNSW SDSLDLEIKQ IQSDAYACSL IRRTKMPLFD
860 870 880 890 900
QFKRAYAEIL FGWQLLSKRA LILKHTQNTP PPVQGVEFVT ECRKCAKPKR
910 920 930 940 950
TPKCEPCKRP VLFCVLCRLP VKGAANACLA CGHGGHIDHM MQWFEKHNVC
960
ATCGCKCLER TSELLALLS
Length:969
Mass (Da):107,969
Last modified:September 18, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB60C97C86C1F1314
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39932 differs from that shown. Reason: Frameshift at position 325.Curated
The sequence AAZ66312 differs from that shown. Reason: Frameshift at position 328.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAS64677.1
AY069787 mRNA Translation: AAL39932.1 Frameshift.
BT023805 mRNA Translation: AAZ66312.1 Frameshift.
BT044210 mRNA Translation: ACH92275.1

NCBI Reference Sequences

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RefSeqi
NP_609485.4, NM_135641.4
NP_995682.1, NM_205960.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.1953

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080196; FBpp0079785; FBgn0032339
FBtr0343622; FBpp0310217; FBgn0032339

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4705

UCSC genome browser

More...
UCSCi
CG4705-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAS64677.1
AY069787 mRNA Translation: AAL39932.1 Frameshift.
BT023805 mRNA Translation: AAZ66312.1 Frameshift.
BT044210 mRNA Translation: ACH92275.1
RefSeqiNP_609485.4, NM_135641.4
NP_995682.1, NM_205960.4
UniGeneiDm.1953

3D structure databases

ProteinModelPortaliQ9VKK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60602, 1 interactor
STRINGi7227.FBpp0079785

PTM databases

iPTMnetiQ9VKK2

Proteomic databases

PaxDbiQ9VKK2
PRIDEiQ9VKK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080196; FBpp0079785; FBgn0032339
FBtr0343622; FBpp0310217; FBgn0032339
GeneIDi34540
KEGGidme:Dmel_CG4705
UCSCiCG4705-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79726
FlyBaseiFBgn0032339 CG4705

Phylogenomic databases

eggNOGiKOG0309 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00940000157600
InParanoidiQ9VKK2
KOiK20409
OMAiFQLCQGT
OrthoDBi590848at2759
PhylomeDBiQ9VKK2

Enzyme and pathway databases

SignaLinkiQ9VKK2

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34540

Protein Ontology

More...
PROi
PR:Q9VKK2

Gene expression databases

BgeeiFBgn0032339 Expressed in 28 organ(s), highest expression level in Malpighian tubule
GenevisibleiQ9VKK2 DM

Family and domain databases

CDDicd16692 mRING-H2-C3H3C2_WDR59, 1 hit
InterProiView protein in InterPro
IPR006575 RWD-domain
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR037591 WDR59
IPR039456 WDR59_mRING-H2-C3H3C2
PANTHERiPTHR22850:SF116 PTHR22850:SF116, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR59_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VKK2
Secondary accession number(s): B5RIT6, Q7KTE5, Q8T9F8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 18, 2013
Last modified: January 16, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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