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Entry version 166 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Amino acid transporter protein JHI-21

Gene

JhI-21

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Amino acid transporter protein JHI-21Imported
Submitted name:
Juvenile hormone Inducible-21, isoform AImported
Submitted name:
Juvenile hormone Inducible-21, isoform BImported
Submitted name:
Juvenile hormone Inducible-21, isoform CImported
Submitted name:
Juvenile hormone Inducible-21, isoform DImported
Submitted name:
Juvenile hormone Inducible-21, isoform EImported
Submitted name:
LD39658pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JhI-21Imported
Synonyms:Dmel\CG12317Imported, JHI-21Imported, Jhl-21Imported
ORF Names:CG12317Imported, Dmel_CG12317Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0028425, JhI-21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 69HelicalSequence analysisAdd BLAST27
Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
Transmembranei109 – 131HelicalSequence analysisAdd BLAST23
Transmembranei193 – 211HelicalSequence analysisAdd BLAST19
Transmembranei231 – 252HelicalSequence analysisAdd BLAST22
Transmembranei264 – 287HelicalSequence analysisAdd BLAST24
Transmembranei307 – 339HelicalSequence analysisAdd BLAST33
Transmembranei384 – 407HelicalSequence analysisAdd BLAST24
Transmembranei419 – 440HelicalSequence analysisAdd BLAST22
Transmembranei446 – 465HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0028425, Expressed in embryo and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088925

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1287, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007946_3_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
HKAFGIH

Database of Orthologous Groups

More...
OrthoDBi
621852at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293, AA/rel_permease1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520, AA_permease_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VKC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDRYANGVT TSLVEPTNGC AAPGNPNPAD GEEKIVLKRK LTLINGVAII
60 70 80 90 100
VGTIIGSGIF IAPTGVFIYT ESVGSSLLIW LTCGILSTIG ALCYAELGTC
110 120 130 140 150
ITRSGGDYAY LLVSFGPLVG FLRLWIALLI IRPTTQTIVA LSFAHYAVKP
160 170 180 190 200
FFPECDPPQN AVKLLAAICL TLLTTINCLS VKVSMKVQDV FTVGKLLALI
210 220 230 240 250
MIILSGLYYM ATGELENFRN PWEGIYTARN IGYAFYSGLF AFGGWNYLNF
260 270 280 290 300
VTEELQDPYK NLPRAIWIAM PLVTSIYVLV NLAYFAVVNK PEMLSSLAVA
310 320 330 340 350
VTFGNRVFGP LAFMVPIFVA LSTFGGVNGV LFTSARLFAT GAQEGHLPKF
360 370 380 390 400
FQLFHVKQQT PIPSLIFTCL MSLLMLLTDN VYQLINYFSS VLWLSVVASI
410 420 430 440 450
AGMLWLRHKR PDLPRPIKVH LALPITFMVS CVTLVLLPNL EEPQNLLIGI
460 470 480 490 500
GITLAGIPFY YAFIARKKKP KCYGRLSNSV VEICRAIFNT TIIESNEAIN
Length:500
Mass (Da):54,821
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48BB44291114FEB8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53154.1
AF273478 mRNA Translation: AAK58692.1
AY051907 mRNA Translation: AAK93331.1
AE014134 Genomic DNA Translation: AAN10800.2
AE014134 Genomic DNA Translation: AFH03670.1
AE014134 Genomic DNA Translation: AHN54377.1
AE014134 Genomic DNA Translation: AHN54378.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245996.1, NM_001259067.1
NP_001285863.1, NM_001298934.1
NP_001285864.1, NM_001298935.1
NP_609542.1, NM_135698.4
NP_723717.2, NM_164988.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089655; FBpp0088598; FBgn0028425
FBtr0089656; FBpp0088925; FBgn0028425
FBtr0305089; FBpp0293626; FBgn0028425
FBtr0342608; FBpp0309548; FBgn0028425
FBtr0346427; FBpp0312092; FBgn0028425

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG12317

UCSC genome browser

More...
UCSCi
CG12317-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53154.1
AF273478 mRNA Translation: AAK58692.1
AY051907 mRNA Translation: AAK93331.1
AE014134 Genomic DNA Translation: AAN10800.2
AE014134 Genomic DNA Translation: AFH03670.1
AE014134 Genomic DNA Translation: AHN54377.1
AE014134 Genomic DNA Translation: AHN54378.1
RefSeqiNP_001245996.1, NM_001259067.1
NP_001285863.1, NM_001298934.1
NP_001285864.1, NM_001298935.1
NP_609542.1, NM_135698.4
NP_723717.2, NM_164988.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0088925

Genome annotation databases

EnsemblMetazoaiFBtr0089655; FBpp0088598; FBgn0028425
FBtr0089656; FBpp0088925; FBgn0028425
FBtr0305089; FBpp0293626; FBgn0028425
FBtr0342608; FBpp0309548; FBgn0028425
FBtr0346427; FBpp0312092; FBgn0028425
GeneIDi34624
KEGGidme:Dmel_CG12317
UCSCiCG12317-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34624
FlyBaseiFBgn0028425, JhI-21

Phylogenomic databases

eggNOGiKOG1287, Eukaryota
HOGENOMiCLU_007946_3_0_1
OMAiHKAFGIH
OrthoDBi621852at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34624, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34624

Gene expression databases

BgeeiFBgn0028425, Expressed in embryo and 20 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002293, AA/rel_permease1
PfamiView protein in Pfam
PF13520, AA_permease_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VKC2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VKC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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