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UniProtKB - Q9VKA4 (Y1760_DROME)
Protein
Probable G-protein coupled receptor CG31760
Gene
CG31760
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Miscellaneous
This protein is translated by readthrough of a stop codon. Readthrough of the terminator codon TAG occurs between the codons for Val-875 and Arg-877. There is currently no sequence that provides the identity of residue 876.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Protein family/group databases
TCDBi | 9.A.14.15.2, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor CG31760 |
Gene namesi | ORF Names:CG31760 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0051760, CG31760 |
VEuPathDBi | VectorBase:FBgn0051760 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | CytoplasmicSequence analysisAdd BLAST | 51 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 512 | ExtracellularSequence analysisAdd BLAST | 440 | |
Transmembranei | 513 – 533 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 534 – 547 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 548 – 568 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 569 – 584 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 585 – 607 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 608 – 619 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 620 – 640 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 641 – 660 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 661 – 681 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 682 – 701 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 702 – 722 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 723 – 730 | ExtracellularSequence analysis | 8 | |
Transmembranei | 731 – 751 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 752 – 1093 | CytoplasmicSequence analysisAdd BLAST | 342 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000372663 | 1 – 1093 | Probable G-protein coupled receptor CG31760Add BLAST | 1093 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 236 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 462 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 476 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 519 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q9VKA4 |
PRIDEi | Q9VKA4 |
PTM databases
GlyGeni | Q9VKA4, 4 sites |
iPTMneti | Q9VKA4 |
Expressioni
Gene expression databases
Bgeei | FBgn0051760, Expressed in central nervous system and 20 other tissues |
Genevisiblei | Q9VKA4, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 60692, 1 interactor |
IntActi | Q9VKA4, 2 interactors |
STRINGi | 7227.FBpp0290241 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 847 – 881 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 847 – 864 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4418, Eukaryota |
InParanoidi | Q9VKA4 |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C IPR043458, GPR158/179 |
PANTHERi | PTHR32546, PTHR32546, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketNote: Isoform C is produced by readthrough of a stop codon between the codons for Val-875 and Arg-877. This is likely to be a rare event with most transcripts using the stop codon following Val-875.Curated
Isoform CImported (identifier: Q9VKA4-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKCWHNVVRR RRKKPTAAAA AKGSKGSHGG VASPRDEDAI CQRQQQVDTY
60 70 80 90 100
TWLTTQAVPL LWLHLLLLVA FAKHAAAATT IATNPEATTT TVSNYTVTTT
110 120 130 140 150
ALSSSTTTTS SGSAPALSSA ADKFAGNWAN LEDSFRNIVR IGDGNTVTRT
160 170 180 190 200
SIEQSLVTIH DIATENLGTL CISTLYRPLQ VPINSERYES SRQKTDLAAS
210 220 230 240 250
ILQEVGIIRH GGLSDALAKG LLTDDFITGA RILALNLTNG AVQSYVWWVK
260 270 280 290 300
GTAAEIQRYD EDGLQIGKKP AGSYPWFDDE TSSPTLRSPK FAPSPPNNYY
310 320 330 340 350
KGWWTYPYFS CSQSRWLVSY SIAIPPIGRH GLRGFISIDI DVSTLRVNQC
360 370 380 390 400
EAEPYPFGSR RQKMQQLQTH NRLGARRSLF LGSRMGAIDE STINDLQAFH
410 420 430 440 450
SSHKCHRTSM VCDYRQPSAE TPTVTGGKLL TTLTGSSSWT RGSYQCLCRG
460 470 480 490 500
GFYSLRHPDG FNGTIMEIAW QEQQDNISNY YSEVFKCLPC APGCDTCTGP
510 520 530 540 550
EPCLANYHWP FRISLLTISI GCACGTFVLA GYLFRHRRVK VFKVASPIFL
560 570 580 590 600
MITLIGCAIM YLEMVAIFPY LDTTWCIATK WTRHMGFCIT YTSLLMKTWR
610 620 630 640 650
VSLTYRVKSA HKIKLNDQQL LQWMVPILLV MLIYLGTWTI SATPTAEVIL
660 670 680 690 700
DQSQLKFKQC SYNWWDHSLA IGEVFFLAWG IRVCYNVRNA ESLYNEARLI
710 720 730 740 750
SYAIYNIALV NIAMVVFHVM LFPNAGPDYK YMLGFVRTQL STTTTIALVF
760 770 780 790 800
GPKILRVFKG QGDKWDQKAK VRSITASFSL NGVGLVPEES PDLYQENEEL
810 820 830 840 850
KEQVQKLAHQ IEFMKTVHMQ MNNRHLKPKP GGYFTITSTS FQAPYSKNTV
860 870 880 890 900
STAQTQTGKD ENSTPTKLKS PKGKVXRGQR SVKDCSIEID GGQGRTTLVE
910 920 930 940 950
DAIEFNFHLA DTEKGLIVQE DERPGSDEEE AALIAQFRRL FAPILDDSLN
960 970 980 990 1000
LYYQLNDLDD TEHVRIHQTV AQMNDLTSSE EETMVTQVNS PSPPPVGVEL
1010 1020 1030 1040 1050
LLPISSDSST ASSSLYAIHT PSPAHPSGVL LMPQNLESPL LSGSDAITIT
1060 1070 1080 1090
EQVELHNPPH HLQLLEDENN TSCSLSSNLT DSKTLDGRTP IVV
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058136 | 877 – 1093 | Missing in isoform B. CuratedAdd BLAST | 217 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53174.3 AE014134 Genomic DNA Translation: ACZ94248.1 AE014134 Genomic DNA Translation: AGB92937.1 AY118394 mRNA Translation: AAM48423.1 |
RefSeqi | NP_001162962.1, NM_001169491.2 NP_001260402.1, NM_001273473.2 NP_723730.2, NM_164996.3 [Q9VKA4-3] |
Genome annotation databases
EnsemblMetazoai | FBtr0331996; FBpp0304318; FBgn0051760 [Q9VKA4-3] |
GeneIDi | 34642 |
KEGGi | dme:Dmel_CG31760 |
UCSCi | CG31760-RA, d. melanogaster [Q9VKA4-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53174.3 AE014134 Genomic DNA Translation: ACZ94248.1 AE014134 Genomic DNA Translation: AGB92937.1 AY118394 mRNA Translation: AAM48423.1 |
RefSeqi | NP_001162962.1, NM_001169491.2 NP_001260402.1, NM_001273473.2 NP_723730.2, NM_164996.3 [Q9VKA4-3] |
3D structure databases
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 60692, 1 interactor |
IntActi | Q9VKA4, 2 interactors |
STRINGi | 7227.FBpp0290241 |
Protein family/group databases
TCDBi | 9.A.14.15.2, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9VKA4, 4 sites |
iPTMneti | Q9VKA4 |
Proteomic databases
PaxDbi | Q9VKA4 |
PRIDEi | Q9VKA4 |
Protocols and materials databases
DNASUi | 34642 |
Genome annotation databases
EnsemblMetazoai | FBtr0331996; FBpp0304318; FBgn0051760 [Q9VKA4-3] |
GeneIDi | 34642 |
KEGGi | dme:Dmel_CG31760 |
UCSCi | CG31760-RA, d. melanogaster [Q9VKA4-3] |
Organism-specific databases
FlyBasei | FBgn0051760, CG31760 |
VEuPathDBi | VectorBase:FBgn0051760 |
Phylogenomic databases
eggNOGi | KOG4418, Eukaryota |
InParanoidi | Q9VKA4 |
Miscellaneous databases
BioGRID-ORCSi | 34642, 0 hits in 3 CRISPR screens |
GenomeRNAii | 34642 |
PROi | PR:Q9VKA4 |
Gene expression databases
Bgeei | FBgn0051760, Expressed in central nervous system and 20 other tissues |
Genevisiblei | Q9VKA4, DM |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C IPR043458, GPR158/179 |
PANTHERi | PTHR32546, PTHR32546, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Y1760_DROME | |
Accessioni | Q9VKA4Primary (citable) accession number: Q9VKA4 Secondary accession number(s): E1JHG5, Q8MT43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | March 16, 2016 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families