Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 148 (12 Aug 2020)
Sequence version 3 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Solute carrier organic anion transporter family member

Gene

Oatp33Ea

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transportUniRule annotation, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.60.1.21, the organo anion transporter (oat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier organic anion transporter family memberUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Oatp33EaImported
Synonyms:Dmel\CG5427Imported, oatp 33EaImported, Oatp33Ea-RAImported
ORF Names:CG5427Imported, Dmel_CG5427Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0032433, Oatp33Ea

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 55HelicalUniRule annotationAdd BLAST20
Transmembranei75 – 96HelicalUniRule annotationAdd BLAST22
Transmembranei103 – 125HelicalUniRule annotationAdd BLAST23
Transmembranei177 – 200HelicalUniRule annotationAdd BLAST24
Transmembranei221 – 247HelicalUniRule annotationAdd BLAST27
Transmembranei267 – 288HelicalUniRule annotationAdd BLAST22
Transmembranei363 – 385HelicalUniRule annotationAdd BLAST23
Transmembranei397 – 422HelicalUniRule annotationAdd BLAST26
Transmembranei434 – 454HelicalUniRule annotationAdd BLAST21
Transmembranei634 – 655HelicalUniRule annotationAdd BLAST22
Transmembranei688 – 709HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0032433, Expressed in midgut and 29 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305305

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini468 – 522Kazal-likeInterPro annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni721 – 745DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3626, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198527

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008954_1_3_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWYYGRT

Database of Orthologous Groups

More...
OrthoDBi
1029129at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002350, Kazal_dom
IPR036259, MFS_trans_sf
IPR004156, OATP

The PANTHER Classification System

More...
PANTHERi
PTHR11388, PTHR11388, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03137, OATP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00805, oat, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51465, KAZAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VK84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVKRRDPN RPPGHYLCGM ANWHPPWLQK YATTKMFMGV YGLLGTIQAM
60 70 80 90 100
SYMYFIVTLT TLEKRFKIPS QTTGIILSGN EISQIMLSLI LSYIGGQRNR
110 120 130 140 150
PRWIAWGIVF CGLSCYILVL PHFIYGAGHE VLQFTKEYQD SLLNGTTGSD
160 170 180 190 200
HSFQNISSVK TERLCGVDKT EDDCDDLFSY VPLVLIFLSQ FVLGVGNTLY
210 220 230 240 250
YSLGQTYLDD NTKKTNTPLM LAVAMALRMI GPVVGFFFGF ISLNTFIDPT
260 270 280 290 300
KTPLIDSKDP RWLGAWWLGW VILGTLMCLF SGLIGLFPKQ LPKVNASRTN
310 320 330 340 350
SHLPLALRQT KEELKREENL SLSSRFSSNA ALDTIGAAAG ANADLPKLKD
360 370 380 390 400
FPRALMRLLR NKLLIFNILS AVFYILGASG FMTFLTKYME VQFHKDAQSA
410 420 430 440 450
TIIVGPISIM GMVVGLIGSG MVLSKKKPSV SKVLMWNVIV GGISILGQIS
460 470 480 490 500
YAFLYCPNTF SMTQAGQLNL TSNCNMNCSC EGISYTPVCH EPTDTTFFSA
510 520 530 540 550
CHAGCRGYNA TSKLYEDCSC VVNDPAPKSA AQRLLNLLQP TPEPELDTTT
560 570 580 590 600
YFDEYLSGVP LLDDNGDFDD QLLSRTRRST SDSVIRPGIC TKNCNWSFWA
610 620 630 640 650
FSITSMIVSW FGSSGRVGNV LVNYRAVAHE DKSFAQGLAL MMISLLALIP
660 670 680 690 700
GPIIFGRLID STCLVWTKTC NGNGNCQLYD QTRFRYSLNF LSCLLTFMGL
710 720 730 740
LFDYLVWYYG RNLDIYGDKE AKEEERANRK DQPITPLLAK KSEQE
Length:745
Mass (Da):83,119
Last modified:July 5, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEBD26AAAFBF1B7FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53195.3
BT125052 mRNA Translation: ADJ93825.1
AE014134 Genomic DNA Translation: AGB92952.1

NCBI Reference Sequences

More...
RefSeqi
NP_001260417.1, NM_001273488.1
NP_609568.3, NM_135724.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080384; FBpp0079966; FBgn0032433
FBtr0333092; FBpp0305305; FBgn0032433

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5427

UCSC genome browser

More...
UCSCi
CG5427-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53195.3
BT125052 mRNA Translation: ADJ93825.1
AE014134 Genomic DNA Translation: AGB92952.1
RefSeqiNP_001260417.1, NM_001273488.1
NP_609568.3, NM_135724.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0305305

Protein family/group databases

TCDBi2.A.60.1.21, the organo anion transporter (oat) family

Genome annotation databases

EnsemblMetazoaiFBtr0080384; FBpp0079966; FBgn0032433
FBtr0333092; FBpp0305305; FBgn0032433
GeneIDi34660
KEGGidme:Dmel_CG5427
UCSCiCG5427-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34660
FlyBaseiFBgn0032433, Oatp33Ea

Phylogenomic databases

eggNOGiKOG3626, Eukaryota
GeneTreeiENSGT00980000198527
HOGENOMiCLU_008954_1_3_1
OMAiVWYYGRT
OrthoDBi1029129at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
34660, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34660

Gene expression databases

BgeeiFBgn0032433, Expressed in midgut and 29 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002350, Kazal_dom
IPR036259, MFS_trans_sf
IPR004156, OATP
PANTHERiPTHR11388, PTHR11388, 2 hits
PfamiView protein in Pfam
PF03137, OATP, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00805, oat, 1 hit
PROSITEiView protein in PROSITE
PS51465, KAZAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VK84_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VK84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again