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Entry version 168 (26 Feb 2020)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

AT30656p

Gene

ACXC

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-163615 PKA activation
R-DME-170660 Adenylate cyclase activating pathway
R-DME-170670 Adenylate cyclase inhibitory pathway
R-DME-418597 G alpha (z) signalling events
R-DME-5610787 Hedgehog 'off' state

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AT30656pImported
Submitted name:
Adenylyl cyclase ACXCImported
Submitted name:
Adenylyl cyclase X C, isoform AImported (EC:4.6.1.1Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACXCImported
Synonyms:ACImported, AcxcImported, DACXCImported, Dmel\CG5983Imported
ORF Names:CG5983Imported, Dmel_CG5983Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0040508 ACXC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei121 – 145HelicalSequence analysisAdd BLAST25
Transmembranei151 – 169HelicalSequence analysisAdd BLAST19
Transmembranei176 – 197HelicalSequence analysisAdd BLAST22
Transmembranei217 – 233HelicalSequence analysisAdd BLAST17
Transmembranei589 – 610HelicalSequence analysisAdd BLAST22
Transmembranei616 – 640HelicalSequence analysisAdd BLAST25
Transmembranei678 – 697HelicalSequence analysisAdd BLAST20
Transmembranei724 – 743HelicalSequence analysisAdd BLAST20
Transmembranei750 – 774HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0040508 Expressed in testis and 7 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VK53 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079994

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VK53

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini316 – 443Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini860 – 1041Guanylate cyclaseInterPro annotationAdd BLAST182

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3619 Eukaryota
COG2114 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001072_2_5_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
KLYHYEM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211 Guanylate_cyc, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55073 SSF55073, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VK53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPRTNSRK SPLKRKRLRP CHLDYANERL WEHSYLREKC KELNLEEEYR
60 70 80 90 100
YYQVRLMVSN LTIFYVLFII LAMSFLTIEL LYVQHYNAVF FNFVIRVVST
110 120 130 140 150
ILVLTVLSIN FCEKFVSRHR WVMIASSVLS VYLVVLTDIV MISYHFYKND
160 170 180 190 200
WPLNTSFDVF TLCMIYMFLP IPSIKGAALL ASSVSLIYVA FFMHSLTFNA
210 220 230 240 250
VYTDRDSFGY DVISTDILHN LGFNMMGIFF RIMNDTMVRA SFLDRHQFIM
260 270 280 290 300
EETWLRHALL QESILLDSIL PPQIAKPVQE KIKSKITQSE NSPDRFQMGP
310 320 330 340 350
RTTESFMAIQ IHPDVSILYA DVVNYTHLTT TLTVGNLVKV LHDLYGRFDI
360 370 380 390 400
AASNFKVQRI KFLGDCYYCV AGLTTPDPDH AKCCVSLGIS MISNIQEVRA
410 420 430 440 450
ERGLDIDMRI GVHSGSLLAG IIGEAKLQFD IWGTDVEIAN HLESTGEPGY
460 470 480 490 500
VHVSGRTLSM LNPADYTILS GTQKAQSDPV LQYIHTYLLT GQVARESFIT
510 520 530 540 550
SIGGVRSSSV LEVKSIDRIR SSRPSQSSMT DEFREEFRNM PVGGINLNSP
560 570 580 590 600
CCRRTRLDTH KKTQREIGIF CAAFKDSSLE WNYLHQPDFI FKSSMLLAWG
610 620 630 640 650
IGCCLIYIQI VTNNFSCTAC IVVDLVTFFF LTSLLCLAWY KNVCWWKSGR
660 670 680 690 700
YEFRIYGKYS CMAFHIFEKI QHSVSLRITV YLGILFSYYA VISLIMLNCD
710 720 730 740 750
RDMYELSYIE SKIYHYEMDR DTCFHPWVFT NMISLILGIS YTFARIPFGL
760 770 780 790 800
KIVISCCETL AYLLIVFFQF AFIFQHSATT TPFMKAELAH CLRVCMMLLT
810 820 830 840 850
MYAKERQSEF NTKMNYKLNV DLQNKQKAAD LTNQSIIILL NNILPSHVVD
860 870 880 890 900
LYLNSLAKHE LYYENYRMVS VMFAMLINFP MNLPSLRVLN DIITQFDRLL
910 920 930 940 950
TAYREYYVVE KIKVVGCTYM AACGLDFNLA SNIRQTDHFR NSSLHVEVEH
960 970 980 990 1000
ARNHRMTDEN YDSDMNNDEV VFIMTTFALD LMRTLAACNR AYSSSFFERS
1010 1020 1030 1040 1050
LSQGKICIGI SSGEIMAGVV GASQPHYDIW GNPVNMASRM ESTGLPGHIQ
1060 1070 1080 1090 1100
VTEESAKILQ EFDIKCIYRG MTFVKGRGDI PTYFVGIDEN LKFMSAKLVN
1110 1120 1130
RSLSRRFSVM SSLDPDSLRK SSSSDQESGE
Length:1,130
Mass (Da):129,845
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB82D7C0DF8FF8568
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q2PDU2Q2PDU2_DROME
Adenylyl cyclase X C, isoform B
ACXC AC, Acxc, DACXC, Dmel\CG5983, CG5983
436Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF177930 mRNA Translation: AAF33109.1
AE014134 Genomic DNA Translation: AAF53226.2
BT021449 mRNA Translation: AAX33597.1

NCBI Reference Sequences

More...
RefSeqi
NP_609593.1, NM_135749.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080413; FBpp0079994; FBgn0040508

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34689

UCSC genome browser

More...
UCSCi
CG5983-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177930 mRNA Translation: AAF33109.1
AE014134 Genomic DNA Translation: AAF53226.2
BT021449 mRNA Translation: AAX33597.1
RefSeqiNP_609593.1, NM_135749.2

3D structure databases

SMRiQ9VK53
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079994

Genome annotation databases

EnsemblMetazoaiFBtr0080413; FBpp0079994; FBgn0040508
GeneIDi34689
UCSCiCG5983-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34689
FlyBaseiFBgn0040508 ACXC

Phylogenomic databases

eggNOGiKOG3619 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00940000168344
HOGENOMiCLU_001072_2_5_1
OMAiKLYHYEM

Enzyme and pathway databases

ReactomeiR-DME-163615 PKA activation
R-DME-170660 Adenylate cyclase activating pathway
R-DME-170670 Adenylate cyclase inhibitory pathway
R-DME-418597 G alpha (z) signalling events
R-DME-5610787 Hedgehog 'off' state

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34689

Gene expression databases

BgeeiFBgn0040508 Expressed in testis and 7 other tissues
ExpressionAtlasiQ9VK53 differential

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VK53_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VK53
Secondary accession number(s): Q9NJA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: February 26, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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