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Entry version 158 (17 Jun 2020)
Sequence version 3 (01 Oct 2002)
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Protein
Submitted name:

Adenylyl cyclase X B

Gene

ACXB

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseImported

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-163615 PKA activation
R-DME-170660 Adenylate cyclase activating pathway
R-DME-170670 Adenylate cyclase inhibitory pathway
R-DME-418597 G alpha (z) signalling events
R-DME-5610787 Hedgehog 'off' state

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Adenylyl cyclase X BImported (EC:4.6.1.1Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACXBImported
Synonyms:ACImported, AC34AImported, Ac34AImported, DACXBImported, Dmel\CG17174Imported
ORF Names:CG17174Imported, Dmel_CG17174Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0040509 ACXB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 73HelicalSequence analysisAdd BLAST25
Transmembranei79 – 100HelicalSequence analysisAdd BLAST22
Transmembranei112 – 134HelicalSequence analysisAdd BLAST23
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei167 – 188HelicalSequence analysisAdd BLAST22
Transmembranei208 – 224HelicalSequence analysisAdd BLAST17
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Transmembranei613 – 632HelicalSequence analysisAdd BLAST20
Transmembranei666 – 689HelicalSequence analysisAdd BLAST24
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Transmembranei745 – 766HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VK52

PRoteomics IDEntifications database

More...
PRIDEi
Q9VK52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0040509 Expressed in testis and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VK52 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VK52 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9VK52, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079995

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VK52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini307 – 434Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini862 – 1028Guanylate cyclaseInterPro annotationAdd BLAST167

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3619 Eukaryota
COG2114 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001072_2_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VK52

KEGG Orthology (KO)

More...
KOi
K01768

Identification of Orthologs from Complete Genome Data

More...
OMAi
PWIFSEQ

Database of Orthologous Groups

More...
OrthoDBi
363718at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00211 Guanylate_cyc, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55073 SSF55073, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VK52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKKTAYAPR KCYLDYTDER LWERGYLKAK CKELCLEEEY KKYQIRLMIS
60 70 80 90 100
YLTVFFPLFI FVVVGCELCP WIFSEQKKLI YYESLTAIVV LVAVPGILSI
110 120 130 140 150
NFFESFVLRH RWIMVFSSIL SAYIVVLVDI FQILVFHFKY HWPLNTLYDV
160 170 180 190 200
FVLCMIYMFL PIPSIRGAAL LATSVSLMYI GLFIYFLKSD DEDISEVVHD
210 220 230 240 250
LDTICVDIFH YLGFNLMGIF FRIMNDTMVR SSFLDRHQFL KEEMWLRQAR
260 270 280 290 300
QQESMLLDSI LPPQIAKPIQ QSIKERIMLS ETDSDRIVVN ARRTENFMAI
310 320 330 340 350
QIHPDVSILY ADVVNYTHLT TTLTVEKLVK VLHDLYGRFD MAASTFKVQR
360 370 380 390 400
IKFLGDCYYC VAGLGEADPD HARMAVSLGI SMIANIQEVR AHRALDIDMR
410 420 430 440 450
IGVHSGTLLA GVIGQAKLQY DIWGPDVDIA NRLEATGKPG YVHVSGRTLS
460 470 480 490 500
SLNVAEYTVF PGTEVAQSDP ILQKQPMTTY LLTAAPSRNS VRSVDAVHSY
510 520 530 540 550
AEIDINALGA SRKSPILRPT LMSDELREEF KKMPVGGFNI RSPCCRDNSN
560 570 580 590 600
DEKVNHGLGM FCVAFKDSSL EWSYLHKPDF ILKYSVLLAW GIGCCLIYIQ
610 620 630 640 650
IVNDKFTICV ECIVIDMVVF TFLTSLLFIS WFKKVCWWRC VENDSRKYGR
660 670 680 690 700
VSCKLFKIWE RIQHSFVLRV TIYMSIVASY YLLISTILLN CDKNQYELDV
710 720 730 740 750
INSKLYHYDI VTDNCFNPWV FTDMISLIVG VSYTFARIPF ALKMLITCCA
760 770 780 790 800
TVAYLVIVFF QYSFIFEHSA TTTPFMKAEL AHCLRVCMML LTMYAKERQS
810 820 830 840 850
EFNTKINFKI NQDLQGKQKA ADITNKSIII LLTNILPSHV VEVYLDSVAN
860 870 880 890 900
HELYYENYKM VSVMFAMLIN FQMDLPSLRV LNDIITEFDR LLNAYKEYYV
910 920 930 940 950
VEKIKVVGCT YMAACGLDFT LAKSKFGSRT HASYSSELEQ VLYRKESKGT
960 970 980 990 1000
ENDHDEVAFI MTTFALDLMR VLSVCNKAYA GRPFDRALST GEICIGISTG
1010 1020 1030 1040 1050
EIMAGVVGAS QPHYDIWGNP VNMASRMEST GLPGHIHVTQ ETANILEQFD
1060 1070 1080 1090 1100
IMCMYRGMTF VKGRGEIPTY FVGIDDNLKF LPSNVKKNNM SKRFSILSSL
1110
VPVHSRSTTS SEYI
Length:1,114
Mass (Da):127,704
Last modified:October 1, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7F60E11C2188EDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53227.3

NCBI Reference Sequences

More...
RefSeqi
NP_620474.2, NM_138989.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080414; FBpp0079995; FBgn0040509

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
53427

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG17174

UCSC genome browser

More...
UCSCi
CG17174-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53227.3
RefSeqiNP_620474.2, NM_138989.3

3D structure databases

SMRiQ9VK52
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VK52, 2 interactors
STRINGi7227.FBpp0079995

Proteomic databases

PaxDbiQ9VK52
PRIDEiQ9VK52

Genome annotation databases

EnsemblMetazoaiFBtr0080414; FBpp0079995; FBgn0040509
GeneIDi53427
KEGGidme:Dmel_CG17174
UCSCiCG17174-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53427
FlyBaseiFBgn0040509 ACXB

Phylogenomic databases

eggNOGiKOG3619 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00940000168344
HOGENOMiCLU_001072_2_4_1
InParanoidiQ9VK52
KOiK01768
OMAiPWIFSEQ
OrthoDBi363718at2759

Enzyme and pathway databases

ReactomeiR-DME-163615 PKA activation
R-DME-170660 Adenylate cyclase activating pathway
R-DME-170670 Adenylate cyclase inhibitory pathway
R-DME-418597 G alpha (z) signalling events
R-DME-5610787 Hedgehog 'off' state

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
53427 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
53427

Gene expression databases

BgeeiFBgn0040509 Expressed in testis and 5 other tissues
ExpressionAtlasiQ9VK52 differential
GenevisibleiQ9VK52 DM

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VK52_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VK52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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