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Entry version 166 (12 Aug 2020)
Sequence version 1 (01 May 2000)
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Protein

Serine/threonine-protein kinase Tor

Gene

Tor

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Regulates growth during animal development by coupling growth factor signaling to nutrient availability (PubMed:11069888). Central regulators of autophagy (PubMed:18604198, PubMed:19225150). May be involved in atg1 phosphorylation (PubMed:19225150). May also be involved, directly or indirectly, in the control of neuronal function (PubMed:15454083). Phosphorylates S6K/p70S6K, in vitro (PubMed:11069888). May regulate the activity of S6K (PubMed:11069885). Overexpression inhibits growth and reduces cell size (PubMed:14505573). Affects the timing of neuronal cell differentiation (PubMed:15454083). Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation (PubMed:15454083). Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism (PubMed:14505573). As part of the TORC1 complex regulates energy homeostasis and promotes certain aspects of larval growth by negatively regulating REPTOR (PubMed:25920570). REPTOR functions downstream of TORC1 to regulate the expression of stress response genes in response to TORC1 inhibition resulting from nutrient deprivation (PubMed:25920570). When TORC1 activity is high it phosphorylates REPTOR which inhibits its recruitment into the nucleus and antagonizes their function (PubMed:25920570). This function is essential under normal feeding conditions to promote TORC1-dependent growth during larval development and, in adults and larvae to prevent the REPTOR-dependent expression of nutrient stress response genes (PubMed:25920570). In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Rag GTPases act as activators of TORC1 in response to amino acid signals (PubMed:18604198).8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1632852, Macroautophagy
R-DME-165159, mTOR signalling
R-DME-166208, mTORC1-mediated signalling
R-DME-3371571, HSF1-dependent transactivation
R-DME-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-DME-389357, CD28 dependent PI3K/Akt signaling
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5628897, TP53 Regulates Metabolic Genes
R-DME-8943724, Regulation of PTEN gene transcription
R-DME-9639288, Amino acids regulate mTORC1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9VK45

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase Tor (EC:2.7.11.1)
Alternative name(s):
Target of rapamycin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tor
ORF Names:CG5092
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0021796, Tor

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Not lethal. Displays phenotypes characteristic of amino acid deprivation, including reduced nucleolar size, lipid vesicle aggregation in the larval fat body, and a cell type-specific pattern of cell cycle arrest that can be bypassed by overexpression of the S-phase regulator cyclin E. Reach only the size of second instar larvae, at which point they undergo cell cycle arrest.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1956S → T: Rapamycin resistance and loss of activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003774581 – 2470Serine/threonine-protein kinase TorAdd BLAST2470

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VK45

PRoteomics IDEntifications database

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PRIDEi
Q9VK45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By PI3K/Akt signaling, or by nutrients such as amino acids, and by high cellular energy levels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0021796, Expressed in eye disc (Drosophila) and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9VK45, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9VK45, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be part of a minimal complex, TORC1, consisting of tor, raptor and lst8. May be part of a minimal complex, TORC2, consisting of tor, rictor and lst8 (By similarity). Self-associates; assembles into homomultimeric complexes.

Component of a multiprotein complex.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
70789, 50 interactors

Protein interaction database and analysis system

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IntActi
Q9VK45, 16 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0080003

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VK45

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati172 – 209HEAT 1Sequence analysisAdd BLAST38
Repeati746 – 785HEAT 2Sequence analysisAdd BLAST40
Repeati791 – 829HEAT 3Sequence analysisAdd BLAST39
Repeati835 – 873HEAT 4Sequence analysisAdd BLAST39
Repeati962 – 999HEAT 5Sequence analysisAdd BLAST38
Repeati1043 – 1080HEAT 6Sequence analysisAdd BLAST38
Repeati1083 – 1122HEAT 7Sequence analysisAdd BLAST40
Repeati1124 – 1160HEAT 8Sequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1349 – 1903FATPROSITE-ProRule annotationAdd BLAST555
Repeati1407 – 1440TPR 1Sequence analysisAdd BLAST34
Repeati1718 – 1751TPR 2PROSITE-ProRule annotationAdd BLAST34
Repeati1854 – 1891HEAT 9Sequence analysisAdd BLAST38
Domaini2103 – 2470PI3K/PI4KPROSITE-ProRule annotationAdd BLAST368
Domaini2438 – 2470FATCPROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi293 – 297Poly-Ser5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0891, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00930000151037

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000178_7_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9VK45

KEGG Orthology (KO)

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KOi
K07203

Identification of Orthologs from Complete Genome Data

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OMAi
LNIQRYP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VK45

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

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PANTHERi
PTHR11139:SF9, PTHR11139:SF9, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 2 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS50005, TPR, 2 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VK45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTSVVQQF VNGLKSRNRN VQNKATQDLL FYVKTELREM SQEELAQFFD
60 70 80 90 100
EFDHHIFTMV NATDINEKKG GALAMKCLIN CEGSLTARKG ISPYLNRLRD
110 120 130 140 150
LLLINDVSVM EIAARSLVKL ANMPTSKGAD SFDFDIKKAF EVLRGERQEY
160 170 180 190 200
RRHSAVFILR ELAIALPTYF YQHILTFFEV IFNAIFDPKP AIRESAGEAL
210 220 230 240 250
RAALIVTAQR ESTKQSSEPQ WYRICYDEAN GSFNADLGSS KDQKGVTRDD
260 270 280 290 300
RIHGGLVVFN ELFRCANATW ERRYTSLKTL FPKTQHNKFL EASSSSSMGS
310 320 330 340 350
QLNTLVPRLK VPFIDKLGST QTHLGEGEHH KGVAKFASHN VLESAYAQEI
360 370 380 390 400
LQEHYTSICD NVLEQRTSKS PYVQQALLQI LPRLAAFNRA VFVEKYLQTC
410 420 430 440 450
VSHLMQILRG KEKDRTVAYI TIGYMAVAVQ SAIEVHLSSI MTSVKVALPS
460 470 480 490 500
KDLTSKRKVP VDPAVFACIT LLAHAVKSEI ADDVKDILEQ MFYTGLSPAL
510 520 530 540 550
TVCLRELSEN VPQLKSAITE GLIGILSQVL MNKAAILPYT ALPTIAIDGS
560 570 580 590 600
LMQNGDGATT VLALKTLGTF NFEEQNMLDF VQRCADYFIV HEQQEIRLEA
610 620 630 640 650
VQTCTRLLKL AVQSSESMEN SKTLSDTVSH VIERLLMVAI TDMDCNVRIR
660 670 680 690 700
ILRSLDETFD GKLAQPESLN SLFITLHDEI FEIRELAMVT IGRLSSINPA
710 720 730 740 750
YVMPKLRTTM IELITDLKYS GMSRNKEQSA KMLDHLVIST PRLISSYMNP
760 770 780 790 800
ILKALVPKLH EPESNPGVIL NVLRTIGDLA EVNGGSDEME LWADDLLSIL
810 820 830 840 850
LEMLGDAGSP DKRGVALWTL GQLISATGRV VTPYHKYPVL IDILINFLKT
860 870 880 890 900
EQRRSIRRET IRVLGLLGAM DPYKHKMNKG LIDSQKDNVL IAYSDGKVDE
910 920 930 940 950
SQDISTAELL VNMGNALDEY YPAVAIAALM RILRDPTLST RHTSVVQAVT
960 970 980 990 1000
FIFQSLGIKC VPYLAQVLPN LLDNVRTADN NLREFLFQQL AILVAFVKLH
1010 1020 1030 1040 1050
IISYMGDIFK LIKEFWTINT PLQNTLINLI EQIAVALGCE FRDYLAELIP
1060 1070 1080 1090 1100
QILRVLQHDN SKDRMVTRRL LQALQKFGST LGYYLPLILP PIVKLFDSPY
1110 1120 1130 1140 1150
VPQQVSMVAL ETINNLACQL DFTDFSSRII HPLVRVLDAE PELRDQAMTT
1160 1170 1180 1190 1200
LRSLAKQLGK KYLVFVPMVQ RTLNKHRIVD PEYEELLSKI KSCSTLADSY
1210 1220 1230 1240 1250
GAGESELRPS RFKNNEPFVT DRNSNNKNLQ VTTNELRTAW QVTRRVSKDD
1260 1270 1280 1290 1300
WVEWLKRLSI GLLKESPSHA LRACRSLAQE YDTLLRDLFN AAFISCWTEL
1310 1320 1330 1340 1350
SPDLKNELTQ SLIQALQVTD MPEITQTILN LAEFMEHCDR DPIPIETKLL
1360 1370 1380 1390 1400
GTRAMACRAY AKALRYKEEE FLLREDSQVF ESLILINNKL QQREAAEGLL
1410 1420 1430 1440 1450
TRYRNAANEL NVQGRWYEKL HNWDEALEHY ERNLKTDSSD LEARLGHMRC
1460 1470 1480 1490 1500
LEALGDWSEL SNVTKHEWEN FGTEAKSRAG PLAAVAAWGL QDWEAMREYV
1510 1520 1530 1540 1550
RCIPEDTQDG SYYRAVLAVH HDDFETAQRL IDETRDLLDT ELTSMAGESY
1560 1570 1580 1590 1600
ERAYGAMVCV QMLAELEEVI QYKLIPERRE PLKTMWWKRL QGGQRLVEDW
1610 1620 1630 1640 1650
RRIIQVHSLV VKPHEDIHTW LKYASLCRKS GSLHLSHKTL VMLLGTDPKL
1660 1670 1680 1690 1700
NPNQPLPCNQ PQVTYAYTKY MAANNQLQEA YEQLTHFVST YSQELSCLPP
1710 1720 1730 1740 1750
EALKQQDQRL MARCYLRMAT WQNKLQDSIR PDAIQGALEC FEKATSYDPN
1760 1770 1780 1790 1800
WYKAWHLWAY MNFKVVQAQK SALDKQQPPG ASMGMTMGSG LDSDLMIIQR
1810 1820 1830 1840 1850
YAVPAVQGFF RSISLIKGNS LQDTLRLLTL WFDYGNHAEV YEALLSGMKL
1860 1870 1880 1890 1900
IEINTWLQVI PQLIARIDTH RQLVGQLIHQ LLMDIGKNHP QALVYPLTVA
1910 1920 1930 1940 1950
SKSASLARRN AAFKILDSMR KHSPTLVEQA VMCSEELIRV AILWHEQWHE
1960 1970 1980 1990 2000
GLEEASRLYF GDRNVKGMFE ILEPLHAMLE RGPQTLKETS FSQAYGRELT
2010 2020 2030 2040 2050
EAYEWSQRYK TSAVVMDLDR AWDIYYHVFQ KISRQLPQLT SLELPYVSPK
2060 2070 2080 2090 2100
LMTCKDLELA VPGSYNPGQE LIRISIIKTN LQVITSKQRP RKLCIRGSNG
2110 2120 2130 2140 2150
KDYMYLLKGH EDLRQDERVM QLFSLVNTLL LDDPDTFRRN LAIQRYAVIP
2160 2170 2180 2190 2200
LSTNSGLIGW VPHCDTLHTL IRDYRDKKKV PLNQEHRTML NFAPDYDHLT
2210 2220 2230 2240 2250
LMQKVEVFEH ALGQTQGDDL AKLLWLKSPS SELWFERRNN YTRSLAVMSM
2260 2270 2280 2290 2300
VGYILGLGDR HPSNLMLDRM SGKILHIDFG DCFEVAMTRE KFPEKIPFRL
2310 2320 2330 2340 2350
TRMLIKAMEV TGIEGTYRRT CESVMLVLRR NKDSLMAVLE AFVYDPLLNW
2360 2370 2380 2390 2400
RLLDVDKKGN DAVAGAGAPG GRGGSGMQDS LSNSVEDSLP MAKSKPYDPT
2410 2420 2430 2440 2450
LQQGGLHNNV ADETNSKASQ VIKRVKCKLT GTDFQTEKSV NEQSQVELLI
2460 2470
QQATNNENLC QCYIGWCPFW
Length:2,470
Mass (Da):281,033
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D78D2ECC07C7FF9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PFS0M9PFS0_DROME
Non-specific serine/threonine prote...
Tor 5092, CT16317, CT24745, CT24817, Dmel\CG5092
2,471Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53237.1

NCBI Reference Sequences

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RefSeqi
NP_524891.1, NM_080152.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0080422; FBpp0080003; FBgn0021796

Database of genes from NCBI RefSeq genomes

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GeneIDi
47396

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG5092

UCSC genome browser

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UCSCi
CG5092-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53237.1
RefSeqiNP_524891.1, NM_080152.3

3D structure databases

SMRiQ9VK45
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi70789, 50 interactors
IntActiQ9VK45, 16 interactors
STRINGi7227.FBpp0080003

Proteomic databases

PaxDbiQ9VK45
PRIDEiQ9VK45

Genome annotation databases

EnsemblMetazoaiFBtr0080422; FBpp0080003; FBgn0021796
GeneIDi47396
KEGGidme:Dmel_CG5092
UCSCiCG5092-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0021796, Tor

Phylogenomic databases

eggNOGiKOG0891, Eukaryota
GeneTreeiENSGT00930000151037
HOGENOMiCLU_000178_7_1_1
InParanoidiQ9VK45
KOiK07203
OMAiLNIQRYP
PhylomeDBiQ9VK45

Enzyme and pathway databases

ReactomeiR-DME-1257604, PIP3 activates AKT signaling
R-DME-1632852, Macroautophagy
R-DME-165159, mTOR signalling
R-DME-166208, mTORC1-mediated signalling
R-DME-3371571, HSF1-dependent transactivation
R-DME-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-DME-389357, CD28 dependent PI3K/Akt signaling
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5628897, TP53 Regulates Metabolic Genes
R-DME-8943724, Regulation of PTEN gene transcription
R-DME-9639288, Amino acids regulate mTORC1
SignaLinkiQ9VK45

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
47396, 2 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Egfr, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
47396

Protein Ontology

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PROi
PR:Q9VK45

Gene expression databases

BgeeiFBgn0021796, Expressed in eye disc (Drosophila) and 37 other tissues
ExpressionAtlasiQ9VK45, baseline and differential
GenevisibleiQ9VK45, DM

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.20.120.150, 1 hit
1.25.10.10, 3 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR024585, DUF3385_TOR
IPR003152, FATC_dom
IPR009076, FRB_dom
IPR036738, FRB_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR026683, TOR
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR11139:SF9, PTHR11139:SF9, 1 hit
PfamiView protein in Pfam
PF11865, DUF3385, 1 hit
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08771, FRB_dom, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01346, DUF3385, 1 hit
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF47212, SSF47212, 1 hit
SSF48371, SSF48371, 2 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS50005, TPR, 2 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOR_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VK45
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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