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UniProtKB - Q9VK34 (SIRT1_DROME)

Entry version 163 (25 May 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

NAD-dependent histone deacetylase sirtuin-1

Gene

Sirt1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.

6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 9.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi339ZincPROSITE-ProRule annotation1
Metal bindingi342ZincPROSITE-ProRule annotation1
Metal bindingi363ZincPROSITE-ProRule annotation1
Metal bindingi366ZincPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei469NAD; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi229 – 248NADBy similarityAdd BLAST20
Nucleotide bindingi313 – 316NADBy similarity4
Nucleotide bindingi427 – 429NADBy similarity3
Nucleotide bindingi452 – 454NADBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.286, 1994

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-427359, SIRT1 negatively regulates rRNA expression
R-DME-9617629, Regulation of FOXO transcriptional activity by acetylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9VK34

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD-dependent histone deacetylase sirtuin-1Imported (EC:2.3.1.286)
Alternative name(s):
Silent information regulator 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sirt1Imported
Synonyms:Sir21 Publication
ORF Names:CG5216Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0024291, Sirt1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0024291

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Causes lethality during development. Induced silencing shortens life span.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004174051 – 823NAD-dependent histone deacetylase sirtuin-1Add BLAST823

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei618Phosphoserine1 Publication1
Modified residuei621Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VK34

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9VK34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0024291, Expressed in embryo and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VK34, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VK34, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the transcriptional repressors hairy (h) and deadpan (dpn); via basic domains. Associates with the Esc/E(z) histone methyltransferase complex.

Interacts directly with E(z) and HDAC1/Rpd3.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		60746, 40 interactors

Protein interaction database and analysis system

More...IntActi		Q9VK34, 5 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0080015

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9VK34

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VK34

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 485Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 146DisorderedSequence analysisAdd BLAST106
Regioni698 – 722DisorderedSequence analysisAdd BLAST25
Regioni777 – 823DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi48 – 65Polar residuesSequence analysisAdd BLAST18
Compositional biasi76 – 103Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi104 – 131Acidic residuesSequence analysisAdd BLAST28
Compositional biasi132 – 146Polar residuesSequence analysisAdd BLAST15
Compositional biasi706 – 722Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi790 – 808Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sirtuin family. Class I subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2684, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159406

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016587_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VK34

Identification of Orthologs from Complete Genome Data

More...OMAi		NGIMKPD

Database of Orthologous Groups

More...OrthoDBi		973532at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VK34

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR003000, Sirtuin
IPR026591, Sirtuin_cat_small_dom_sf
IPR026590, Ssirtuin_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02146, SIR2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52467, SSF52467, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50305, SIRTUIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VK34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMENYEEIRL GHIRSKDLGN QVPDTTQFYP PTKFDFGAEI LASTSTEAEA 
        60         70         80         90        100
EAEATATTTE PATSELAGKA NGEIKTKTLA AREEQEIGAN LEHKTKNPTK 
       110        120        130        140        150
SMGEDEDDEE EEEEDDEEEE EDDEEGITGT SNEDEDSSSN CSSSVEPDWK 
       160        170        180        190        200
LRWLQREFYT GRVPRQVIAS IMPHFATGLA GDTDDSVLWD YLAHLLNEPK 
       210        220        230        240        250
RRNKLASVNT FDDVISLVKK SQKIIVLTGA GVSVSCGIPD FRSTNGIYAR 
       260        270        280        290        300
LAHDFPDLPD PQAMFDINYF KRDPRPFYKF AREIYPGEFQ PSPCHRFIKM 
       310        320        330        340        350
LETKGKLLRN YTQNIDTLER VAGIQRVIEC HGSFSTASCT KCRFKCNADA 
       360        370        380        390        400
LRADIFAQRI PVCPQCQPNK EQSVDASVAV TEEELRQLVE NGIMKPDIVF 
       410        420        430        440        450
FGEGLPDEYH TVMATDKDVC DLLIVIGSSL KVRPVAHIPS SIPATVPQIL 
       460        470        480        490        500
INREQLHHLK FDVELLGDSD VIINQICHRL SDNDDCWRQL CCDESVLTES 
       510        520        530        540        550
KELMPPEHSN HHLHHHLLHH RHCSSESERQ SQLDTDTQSI KSNSSADYIL 
       560        570        580        590        600
GSAGTCSDSG FESSTFSCGK RSTAAEAAAI ERIKTDILVE LNETTALSCD 
       610        620        630        640        650
RLGLEGPQTT VESYRHLSID SSKDSGIEQC DNEATPSYVR PSNLVQETKT 
       660        670        680        690        700
VAPSLTPIPQ QRGKRQTAAE RLQPGTFYSH TNNYSYVFPG AQVFWDNDYS 
       710        720        730        740        750
DDDDEEEERS HNRHSDLFGN VGHNYKDDDE DACDLNAVPL SPLLPPSLEA 
       760        770        780        790        800
HIVTDIVNGS NEPLPNSSPG QKRTACIIEQ QPTPAIETEI PPLKKRRPSE 
       810        820 
ENKQQTQIER SEESPPPGQL AAV
Length:823
Mass (Da):91,837
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DD1EBA975A263D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53 – 54Missing in AAC79684 (PubMed:12663533).Curated2
Sequence conflicti104E → K in ADG03442 (Ref. 4) Curated1
Sequence conflicti290Q → QFQ in AAC79684 (PubMed:12663533).Curated1
Sequence conflicti518L → H in AAC79684 (PubMed:12663533).Curated1
Sequence conflicti746P → H in AAC79684 (PubMed:12663533).Curated1
Sequence conflicti753V → F in AAC79684 (PubMed:12663533).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF068758 mRNA Translation: AAC79684.1
AE014134 Genomic DNA Translation: AAF53248.1
BT124857 mRNA Translation: ADG03442.1
BT133215 mRNA Translation: AFA28456.1
BT133274 mRNA Translation: AFC38905.1

NCBI Reference Sequences

More...RefSeqi		NP_477351.1, NM_058003.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0080434; FBpp0080015; FBgn0024291

Database of genes from NCBI RefSeq genomes

More...GeneIDi		34708

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG5216

UCSC genome browser

More...UCSCi		CG5216-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068758 mRNA Translation: AAC79684.1
AE014134 Genomic DNA Translation: AAF53248.1
BT124857 mRNA Translation: ADG03442.1
BT133215 mRNA Translation: AFA28456.1
BT133274 mRNA Translation: AFC38905.1
RefSeqiNP_477351.1, NM_058003.4

3D structure databases

AlphaFoldDBiQ9VK34
SMRiQ9VK34
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi60746, 40 interactors
IntActiQ9VK34, 5 interactors
STRINGi7227.FBpp0080015

PTM databases

iPTMnetiQ9VK34

Proteomic databases

PaxDbiQ9VK34

Genome annotation databases

EnsemblMetazoaiFBtr0080434; FBpp0080015; FBgn0024291
GeneIDi34708
KEGGidme:Dmel_CG5216
UCSCiCG5216-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23411
FlyBaseiFBgn0024291, Sirt1
VEuPathDBiVectorBase:FBgn0024291

Phylogenomic databases

eggNOGiKOG2684, Eukaryota
GeneTreeiENSGT00940000159406
HOGENOMiCLU_016587_1_0_1
InParanoidiQ9VK34
OMAiNGIMKPD
OrthoDBi973532at2759
PhylomeDBiQ9VK34

Enzyme and pathway databases

BRENDAi2.3.1.286, 1994
ReactomeiR-DME-427359, SIRT1 negatively regulates rRNA expression
R-DME-9617629, Regulation of FOXO transcriptional activity by acetylation
SignaLinkiQ9VK34

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		34708, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Sirt1, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		34708

Protein Ontology

More...PROi		PR:Q9VK34

Gene expression databases

BgeeiFBgn0024291, Expressed in embryo and 39 other tissues
ExpressionAtlasiQ9VK34, baseline and differential
GenevisibleiQ9VK34, DM

Family and domain databases

Gene3Di3.30.1600.10, 1 hit
InterProiView protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR003000, Sirtuin
IPR026591, Sirtuin_cat_small_dom_sf
IPR026590, Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146, SIR2, 1 hit
SUPFAMiSSF52467, SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305, SIRTUIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIRT1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VK34
Secondary accession number(s): D5SHQ6, O96505
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: May 1, 2000
Last modified: May 25, 2022
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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