Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proteasome subunit alpha type

Gene

Prosalpha6T

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-negative bacterium Source: FlyBase
  • negative regulation of innate immune response Source: FlyBase
  • spermatid nucleus elongation Source: FlyBase
  • sperm individualization Source: FlyBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:Prosalpha6TImported
Synonyms:5648Imported, Alpha6TImported, alpha6TImported, Dmel\CG5648Imported, Pros-alpha-6TImported, prosalpha6TImported
ORF Names:CG5648Imported, Dmel_CG5648Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032492 Prosalpha6T

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomePROSITE-ProRule annotationImported

PTM / Processingi

Proteomic databases

PRIDEiQ9VK14

Expressioni

Gene expression databases

BgeeiFBgn0032492

Interactioni

Subunit structurei

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.UniRule annotation

Protein-protein interaction databases

IntActiQ9VK14, 15 interactors
STRINGi7227.FBpp0080028

Structurei

3D structure databases

SMRiQ9VK14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 28PROTEASOME_ALPHA_1InterPro annotationAdd BLAST23

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0863 Eukaryota
COG0638 LUCA
GeneTreeiENSGT00550000074855
KOiK02725
OMAiLNCKAMA
OrthoDBiEOG091G0DNK

Family and domain databases

CDDicd03749 proteasome_alpha_type_1, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR035144 Proteasome_alpha1
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF12 PTHR11599:SF12, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VK14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDNDT TTWSPQGRLF QVEYAMEAVK QGAATVGLKG TDYAVLAALC
60 70 80 90 100
RTSKDTNTLQ RKIMPVDDHV GMSIAGLTAD ARVVCQYMRT ECMAYRHSYN
110 120 130 140 150
AEFPVRRLVS NLGNKLQTTT QRYDRRPYGV GLLVAGYDEQ GPHIYQVMPT
160 170 180 190 200
ANVLNCKAMA IGSRSQSART YLERNMESFE DCDMDELICH AIQAIRGSLG
210 220 230 240 250
SDDVENLTIN VAIVGKDVPF KMFTEAENQK YVKLVKAMDP PLEADHDPLS
260 270 280
EEGMSDDDMT DHGPSSSGVP PNDTSDMETT ASTGGSDAH
Length:289
Mass (Da):31,903
Last modified:May 1, 2000 - v1
Checksum:iE06DCC86D120E538
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53268.1
AY075285 mRNA Translation: AAL68152.1
AY147241 Genomic DNA Translation: AAN63095.1
RefSeqiNP_609623.1, NM_135779.3
UniGeneiDm.5556

Genome annotation databases

EnsemblMetazoaiFBtr0080448; FBpp0080028; FBgn0032492
GeneIDi34726
KEGGidme:Dmel_CG5648
UCSCiCG5648-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VK14_DROME
AccessioniPrimary (citable) accession number: Q9VK14
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health