UniProtKB - Q9VJJ7 (TRPG_DROME)
Protein
Transient receptor potential-gamma protein
Gene
Trpgamma
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
A light-sensitive calcium channel that is required for inositide-mediated Ca2+ entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl.By similarity1 Publication
GO - Molecular functioni
- calcium channel activity Source: UniProtKB
- cation channel activity Source: FlyBase
- inositol 1,4,5 trisphosphate binding Source: GO_Central
- mechanosensitive ion channel activity Source: FlyBase
- store-operated calcium channel activity Source: GO_Central
GO - Biological processi
- adult walking behavior Source: FlyBase
- calcium ion transmembrane transport Source: GO_Central
- calcium ion transport Source: UniProtKB
- cation transport Source: FlyBase
- detection of light stimulus involved in visual perception Source: UniProtKB
- manganese ion transport Source: GO_Central
- neuromuscular process controlling posture Source: FlyBase
- regulation of cytosolic calcium ion concentration Source: GO_Central
- response to light stimulus Source: UniProtKB
Keywordsi
Molecular function | Calcium channel, Ion channel |
Biological process | Calcium transport, Ion transport, Sensory transduction, Transport, Vision |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-DME-3295583, TRP channels R-DME-5578775, Ion homeostasis R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | Q9VJJ7 |
Protein family/group databases
TCDBi | 1.A.4.1.15, the transient receptor potential ca(2+) channel (trp-cc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transient receptor potential-gamma proteinShort name: TRPgamma Alternative name(s): Transient receptor potential cation channel gamma |
Gene namesi | Name:Trpgamma ORF Names:CG5996 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0032593, Trpgamma |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cation channel complex Source: FlyBase
- neuronal cell body Source: FlyBase
- proximal dendrite Source: FlyBase
- rhabdomere Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 325 | CytoplasmicSequence analysisAdd BLAST | 325 | |
Transmembranei | 326 – 346 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 347 – 403 | ExtracellularSequence analysisAdd BLAST | 57 | |
Transmembranei | 404 – 424 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 425 – 444 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 445 – 465 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 466 – 492 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 493 – 513 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 514 – 535 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 536 – 556 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 557 – 629 | ExtracellularSequence analysisAdd BLAST | 73 | |
Transmembranei | 630 – 650 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 651 – 1128 | CytoplasmicSequence analysisAdd BLAST | 478 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215358 | 1 – 1128 | Transient receptor potential-gamma proteinAdd BLAST | 1128 |
Proteomic databases
PaxDbi | Q9VJJ7 |
PRIDEi | Q9VJJ7 |
Expressioni
Tissue specificityi
Expressed predominantly in the rhabdomeres of photoreceptor cells.1 Publication
Gene expression databases
Bgeei | FBgn0032593, Expressed in central nervous system and 14 other tissues |
ExpressionAtlasi | Q9VJJ7, baseline and differential |
Genevisiblei | Q9VJJ7, DM |
Interactioni
Subunit structurei
Interacts preferentially with trpl and interacts to a lower extent with trp.
1 PublicationProtein-protein interaction databases
BioGRIDi | 60999, 1 interactor |
IntActi | Q9VJJ7, 2 interactors |
STRINGi | 7227.FBpp0080498 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 57 – 86 | ANK 1Add BLAST | 30 | |
Repeati | 131 – 160 | ANK 2Add BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3609, Eukaryota |
HOGENOMi | CLU_005716_3_1_1 |
InParanoidi | Q9VJJ7 |
OMAi | NMAQFYY |
PhylomeDBi | Q9VJJ7 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 1 hit |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9VJJ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEEENTIRP HQEIRQLTLE EKKFLLAVER GDMAGTRRML QKAQDTEYIN
60 70 80 90 100
VNCVDPLGRT ALLMAIDNEN LEMVELLINY NVDTKDALLH SISEEFVEAV
110 120 130 140 150
EVLLDHENVT FHSEGNHSWE SASEDTSTFT PDITPLILAA HRDNYEIIKI
160 170 180 190 200
LLDRGAVLPM PHDVRCGCDE CVQSRQEDSL RHSRSRINAY RALASPSLIA
210 220 230 240 250
LSSKDPILTA FELSWELRRL SFLEHEFKNE YQELRKQCQD FATALLDHTR
260 270 280 290 300
TSHELEILLN HDPTGPVYEH GERMHLNRLK LAIKLRQKKF VAHSNVQQLL
310 320 330 340 350
ASIWYEGLPG FRRKNMALQA VDIIRIGIMF PIFSLAYILA PYSSIGQTMR
360 370 380 390 400
KPFIKFICHS ASYFTFLFLL MLASQRIETF IGGWFFADSS GMLNTMEELP
410 420 430 440 450
TKRGAKPTFI EWLILAWVSG LIWSEVKQLW DVGLQEYLND MWNVIDFVTN
460 470 480 490 500
SLYVATVALR VVSFFQVQKE MIYNSHATDL PRERWDAWDP MLISEGLFSA
510 520 530 540 550
ANIFSSLKLV YIFSVNPHLG PLQVSLSRMV MDIMKFFFLY VLVLFAFGSG
560 570 580 590 600
LNQLLWYYAD LEKKRCPEVS PMSALLNMNG TNDPNACIVW RRFSNLFETT
610 620 630 640 650
QTLFWAVFGL IDLDSFELDG IKIFTRFWGM LMFGTYSVIN IVVLLNLLIA
660 670 680 690 700
MMNHSYQLIS ERADVEWKFA RSKLWISYFE EGGTCPPPFN IIPTPKSIWY
710 720 730 740 750
AIKWMRRVFC SGSSAARREH LKTIRRKAQQ ASDRDFKYQQ IMRNLVRRYV
760 770 780 790 800
TVEQRKAESQ GVTEDDVNEI KQDISAFRCE LVEILKNSGM DTNVTAGQGG
810 820 830 840 850
GGGGKKNRQK ERRLMKGFNI APPGSTGSLA PVAEFSTSLD NYDNQHEILS
860 870 880 890 900
STLSTLFTPN FMHKRQQSQA GSGGGGSESP TTPTAPQGTQ GAAMTASSQV
910 920 930 940 950
TKYNKSALKP YNKRIAGHKK RWGTLIEAAK VGNVSKMLGR SKSEDSVCNS
960 970 980 990 1000
SHTSTPVHGQ MRVTYAQNSP QQEYGYHGET SSTTISTPTP TISVVSNSPA
1010 1020 1030 1040 1050
AHAGVGSHFF HTTSGLTAIA ALKRKRKKFS SSKNICPVTE SVAAANAAEI
1060 1070 1080 1090 1100
LNDKTLKRVS SYPAAEAGVQ HNPAQLVKPR RHEQTQSQHD SVETNSTFTL
1110 1120
SIDPSNTSVN SREPLISTSC VSTTGAIG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB7YZW4 | B7YZW4_DROME | Transient receptor potential cation... | Trpgamma Dmel\CG5996, DmTRPgamma, dTRPg, dTRPgamma, Trp-gamma | 1,188 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 195 | S → G in CAB96204 (PubMed:10896160).Curated | 1 | |
Sequence conflicti | 195 | S → G in CAB96205 (PubMed:10896160).Curated | 1 | |
Sequence conflicti | 222 | F → L in CAB96204 (PubMed:10896160).Curated | 1 | |
Sequence conflicti | 222 | F → L in CAB96205 (PubMed:10896160).Curated | 1 | |
Sequence conflicti | 1053 | D → N in CAB96204 (PubMed:10896160).Curated | 1 | |
Sequence conflicti | 1053 | D → N in CAB96205 (PubMed:10896160).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277967 mRNA Translation: CAB96204.1 AJ277968 mRNA Translation: CAB96205.1 AE014134 Genomic DNA Translation: AAF53548.2 AE014134 Genomic DNA Translation: AAN10950.1 |
RefSeqi | NP_609802.1, NM_135958.5 NP_723983.1, NM_165169.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0080945; FBpp0080498; FBgn0032593 FBtr0080946; FBpp0080499; FBgn0032593 |
GeneIDi | 34991 |
KEGGi | dme:Dmel_CG5996 |
UCSCi | CG5996-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ277967 mRNA Translation: CAB96204.1 AJ277968 mRNA Translation: CAB96205.1 AE014134 Genomic DNA Translation: AAF53548.2 AE014134 Genomic DNA Translation: AAN10950.1 |
RefSeqi | NP_609802.1, NM_135958.5 NP_723983.1, NM_165169.5 |
3D structure databases
SMRi | Q9VJJ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 60999, 1 interactor |
IntActi | Q9VJJ7, 2 interactors |
STRINGi | 7227.FBpp0080498 |
Protein family/group databases
TCDBi | 1.A.4.1.15, the transient receptor potential ca(2+) channel (trp-cc) family |
Proteomic databases
PaxDbi | Q9VJJ7 |
PRIDEi | Q9VJJ7 |
Genome annotation databases
EnsemblMetazoai | FBtr0080945; FBpp0080498; FBgn0032593 FBtr0080946; FBpp0080499; FBgn0032593 |
GeneIDi | 34991 |
KEGGi | dme:Dmel_CG5996 |
UCSCi | CG5996-RA, d. melanogaster |
Organism-specific databases
CTDi | 34991 |
FlyBasei | FBgn0032593, Trpgamma |
Phylogenomic databases
eggNOGi | KOG3609, Eukaryota |
HOGENOMi | CLU_005716_3_1_1 |
InParanoidi | Q9VJJ7 |
OMAi | NMAQFYY |
PhylomeDBi | Q9VJJ7 |
Enzyme and pathway databases
Reactomei | R-DME-3295583, TRP channels R-DME-5578775, Ion homeostasis R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | Q9VJJ7 |
Miscellaneous databases
BioGRID-ORCSi | 34991, 0 hits in 3 CRISPR screens |
GenomeRNAii | 34991 |
PROi | PR:Q9VJJ7 |
Gene expression databases
Bgeei | FBgn0032593, Expressed in central nervous system and 14 other tissues |
ExpressionAtlasi | Q9VJJ7, baseline and differential |
Genevisiblei | Q9VJJ7, DM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 1 hit |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPG_DROME | |
Accessioni | Q9VJJ7Primary (citable) accession number: Q9VJJ7 Secondary accession number(s): A4V0S8, Q9N6L1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families