Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (12 Aug 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

DNA-directed RNA polymerase II subunit RPB11

Gene

Rpb11

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • transcription by RNA polymerase II Source: FlyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-112382, Formation of RNA Pol II elongation complex
R-DME-113418, Formation of the Early Elongation Complex
R-DME-5578749, Transcriptional regulation by small RNAs
R-DME-674695, RNA Polymerase II Pre-transcription Events
R-DME-6781823, Formation of TC-NER Pre-Incision Complex
R-DME-6782135, Dual incision in TC-NER
R-DME-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-DME-6803529, FGFR2 alternative splicing
R-DME-6807505, RNA polymerase II transcribes snRNA genes
R-DME-72086, mRNA Capping
R-DME-72163, mRNA Splicing - Major Pathway
R-DME-72165, mRNA Splicing - Minor Pathway
R-DME-72203, Processing of Capped Intron-Containing Pre-mRNA
R-DME-73776, RNA Polymerase II Promoter Escape
R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953, RNA Polymerase II Transcription Initiation
R-DME-75955, RNA Polymerase II Transcription Elongation
R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DME-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-DME-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit RPB11
Short name:
RNA polymerase II subunit B11
Alternative name(s):
DNA-directed RNA polymerase II 13.3 kDa polypeptide
DNA-directed RNA polymerase II subunit J
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rpb11
ORF Names:CG6840
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0032634, Rpb11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001493121 – 117DNA-directed RNA polymerase II subunit RPB11Add BLAST117

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VJE4

PRoteomics IDEntifications database

More...
PRIDEi
Q9VJE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0032634, Expressed in embryo and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VJE4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VJE4, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61039, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-20854N

Protein interaction database and analysis system

More...
IntActi
Q9VJE4, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080564

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VJE4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4392, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_090381_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VJE4

KEGG Orthology (KO)

More...
KOi
K03008

Identification of Orthologs from Complete Genome Data

More...
OMAi
HKFVLRI

Database of Orthologous Groups

More...
OrthoDBi
1398114at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VJE4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06926, RNAP_II_RPB11, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1360.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037685, RBP11
IPR036603, RBP11-like
IPR009025, RBP11-like_dimer
IPR008193, RNA_pol_Rpb11_13-16kDa_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13656, RNA_pol_L_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55257, SSF55257, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01154, RNA_POL_L_13KD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VJE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAPPTFESF LLYEGEKKII KELDTKVTNA AIFTINKEDH TLGNMIRNQL
60 70 80 90 100
LKDPNVLFAG YKVPHPLEHK FVIRIQTTAD YSPQEAFMNA ITDLLAELSL
110
FEERFKDAIK EKKEGGD
Length:117
Mass (Da):13,385
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFCA3D43E4947943
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53606.1

NCBI Reference Sequences

More...
RefSeqi
NP_609836.1, NM_135992.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081011; FBpp0080564; FBgn0032634

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6840

UCSC genome browser

More...
UCSCi
CG6840-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53606.1
RefSeqiNP_609836.1, NM_135992.4

3D structure databases

SMRiQ9VJE4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61039, 5 interactors
DIPiDIP-20854N
IntActiQ9VJE4, 3 interactors
STRINGi7227.FBpp0080564

Proteomic databases

PaxDbiQ9VJE4
PRIDEiQ9VJE4

Genome annotation databases

EnsemblMetazoaiFBtr0081011; FBpp0080564; FBgn0032634
GeneIDi35043
KEGGidme:Dmel_CG6840
UCSCiCG6840-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35043
FlyBaseiFBgn0032634, Rpb11

Phylogenomic databases

eggNOGiKOG4392, Eukaryota
GeneTreeiENSGT00550000074975
HOGENOMiCLU_090381_2_2_1
InParanoidiQ9VJE4
KOiK03008
OMAiHKFVLRI
OrthoDBi1398114at2759
PhylomeDBiQ9VJE4

Enzyme and pathway databases

ReactomeiR-DME-112382, Formation of RNA Pol II elongation complex
R-DME-113418, Formation of the Early Elongation Complex
R-DME-5578749, Transcriptional regulation by small RNAs
R-DME-674695, RNA Polymerase II Pre-transcription Events
R-DME-6781823, Formation of TC-NER Pre-Incision Complex
R-DME-6782135, Dual incision in TC-NER
R-DME-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-DME-6803529, FGFR2 alternative splicing
R-DME-6807505, RNA polymerase II transcribes snRNA genes
R-DME-72086, mRNA Capping
R-DME-72163, mRNA Splicing - Major Pathway
R-DME-72165, mRNA Splicing - Minor Pathway
R-DME-72203, Processing of Capped Intron-Containing Pre-mRNA
R-DME-73776, RNA Polymerase II Promoter Escape
R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953, RNA Polymerase II Transcription Initiation
R-DME-75955, RNA Polymerase II Transcription Elongation
R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DME-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-DME-9018519, Estrogen-dependent gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35043, 1 hit in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35043

Protein Ontology

More...
PROi
PR:Q9VJE4

Gene expression databases

BgeeiFBgn0032634, Expressed in embryo and 39 other tissues
ExpressionAtlasiQ9VJE4, baseline and differential
GenevisibleiQ9VJE4, DM

Family and domain databases

CDDicd06926, RNAP_II_RPB11, 1 hit
Gene3Di3.30.1360.10, 1 hit
InterProiView protein in InterPro
IPR037685, RBP11
IPR036603, RBP11-like
IPR009025, RBP11-like_dimer
IPR008193, RNA_pol_Rpb11_13-16kDa_CS
PfamiView protein in Pfam
PF13656, RNA_pol_L_2, 1 hit
SUPFAMiSSF55257, SSF55257, 1 hit
PROSITEiView protein in PROSITE
PS01154, RNA_POL_L_13KD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPB11_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VJE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: August 12, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again