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Entry version 145 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Conserved oligomeric Golgi complex subunit 5

Gene

fws

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal Golgi function and necessary during spermatogenesis. Required for cleavage furrow ingression during cytokinesis in dividing spermatocytes and for the extensive polarized cell growth that accompanies spermatid elongation.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Protein transport, Spermatogenesis, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6807878, COPI-mediated anterograde transport
R-DME-6811438, Intra-Golgi traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 5
Short name:
COG complex subunit 5
Alternative name(s):
Component of oligomeric Golgi complex 5
Protein four way stop
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fws
ORF Names:CG6549
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0024689, fws

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Males are sterile.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135111 – 751Conserved oligomeric Golgi complex subunit 5Add BLAST751

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VJD3

PRoteomics IDEntifications database

More...
PRIDEi
Q9VJD3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryos, and adult males and females.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0024689, Expressed in embryo and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VJD3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VJD3, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61050, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-17233N

Protein interaction database and analysis system

More...
IntActi
Q9VJD3, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080552

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VJD3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni244 – 263DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COG5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2211, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009839_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VJD3

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSFDECP

Database of Orthologous Groups

More...
OrthoDBi
871605at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VJD3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019465, Cog5

The PANTHER Classification System

More...
PANTHERi
PTHR13228, PTHR13228, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10392, COG5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VJD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTGDPVATK TPNAADSDDN DFTASMSHLT IGQQIQELSK QLQNTKEELH
60 70 80 90 100
QQVRDKHGAL LQQATHAGRF DAALNALAED VQRVRETGHR LKNQVDTQYQ
110 120 130 140 150
QVENQTQVLG RLHDVSHLLR SAGTLLSLTA KLKATKDVLR LAEIHFELGQ
160 170 180 190 200
LIEDKELKDI DFIQQERAYV ISSAQKIRNL TQMQLVTGLQ ERNENQVVNA
210 220 230 240 250
LKIFMNFNTL EKSLDNLLAT FIADMEQSLK ECFAGNDISV LNKSPTHNVS
260 270 280 290 300
KPAPSRGPGK TPQLTTTQNF RAKFWKSLHW LLYDELFETC TQIKLLKTAL
310 320 330 340 350
EQINQFGYTS ESSDQCIPQR FWQQVQQLLR KSFDECPQHV TQTLQEGLSK
360 370 380 390 400
LLTSARGLEQ RLHGEFQFDN ELFAPLEVGY VSKCAANFKA CLAGVDLPGN
410 420 430 440 450
ETVDNFIRVA STELSAALID SRLTNAIANV FAACGKELCT KLEAQIKLGA
460 470 480 490 500
DSKQVVDLPN LQQQQNTQLA NVLFYYKDSV RRMLSDLHVH FEKTPGTARE
510 520 530 540 550
IISRSLEQAD LLIGTILQQI MESIITTISI IVLSMHREPG LNSERMSTTG
560 570 580 590 600
PSMYMKELQE FVNRSWSHHI ALFDDKQMTK KCGHELAKRC IELFLHNVCI
610 620 630 640 650
LRPLSSCGRQ RLKQDCQHME QALKPLCPNL AELGKPSRLL RAMSLLIVQT
660 670 680 690 700
AEELVKQTIG EDSLVPSYIV LLLLFGHAGA DLQSPHTTAN WSNERLIEWL
710 720 730 740 750
DGHTAEREKL ELISGALQRY RDNARRKNIQ QYDEVYPMMV DYFEQALKAL

P
Length:751
Mass (Da):84,954
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE32B1D05BEEF6EBA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NCV1M9NCV1_DROME
Conserved oligomeric Golgi complex ...
fws anon-EST:Posey162, anon-EST:Posey186, COG5, Cog5, dCOG5
751Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39480 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53619.1
AE014134 Genomic DNA Translation: AAN10990.1
BT003257 mRNA Translation: AAO25014.1
AY069335 mRNA Translation: AAL39480.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001246059.1, NM_001259130.2
NP_001286015.1, NM_001299086.1
NP_001286016.1, NM_001299087.1
NP_523590.1, NM_078866.4
NP_724058.1, NM_165221.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0080999; FBpp0080552; FBgn0024689
FBtr0081000; FBpp0080553; FBgn0024689
FBtr0305685; FBpp0296965; FBgn0024689
FBtr0346626; FBpp0312206; FBgn0024689
FBtr0346627; FBpp0312207; FBgn0024689

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6549

UCSC genome browser

More...
UCSCi
CG6549-RC, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53619.1
AE014134 Genomic DNA Translation: AAN10990.1
BT003257 mRNA Translation: AAO25014.1
AY069335 mRNA Translation: AAL39480.1 Different initiation.
RefSeqiNP_001246059.1, NM_001259130.2
NP_001286015.1, NM_001299086.1
NP_001286016.1, NM_001299087.1
NP_523590.1, NM_078866.4
NP_724058.1, NM_165221.3

3D structure databases

SMRiQ9VJD3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61050, 6 interactors
DIPiDIP-17233N
IntActiQ9VJD3, 9 interactors
STRINGi7227.FBpp0080552

Proteomic databases

PaxDbiQ9VJD3
PRIDEiQ9VJD3

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
35054

Genome annotation databases

EnsemblMetazoaiFBtr0080999; FBpp0080552; FBgn0024689
FBtr0081000; FBpp0080553; FBgn0024689
FBtr0305685; FBpp0296965; FBgn0024689
FBtr0346626; FBpp0312206; FBgn0024689
FBtr0346627; FBpp0312207; FBgn0024689
GeneIDi35054
KEGGidme:Dmel_CG6549
UCSCiCG6549-RC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100529224
FlyBaseiFBgn0024689, fws

Phylogenomic databases

eggNOGiKOG2211, Eukaryota
GeneTreeiENSGT00390000004586
HOGENOMiCLU_009839_1_1_1
InParanoidiQ9VJD3
OMAiKSFDECP
OrthoDBi871605at2759
PhylomeDBiQ9VJD3

Enzyme and pathway databases

ReactomeiR-DME-6807878, COPI-mediated anterograde transport
R-DME-6811438, Intra-Golgi traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35054, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35054

Protein Ontology

More...
PROi
PR:Q9VJD3

Gene expression databases

BgeeiFBgn0024689, Expressed in embryo and 40 other tissues
ExpressionAtlasiQ9VJD3, baseline and differential
GenevisibleiQ9VJD3, DM

Family and domain databases

InterProiView protein in InterPro
IPR019465, Cog5
PANTHERiPTHR13228, PTHR13228, 1 hit
PfamiView protein in Pfam
PF10392, COG5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOG5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VJD3
Secondary accession number(s): Q53YG5, Q8T0G3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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