UniProtKB - Q9VJD2 (LTOR3_DROME)
Protein
Ragulator complex protein LAMTOR3 homolog
Gene
CG5110
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.1 Publication
GO - Biological processi
- cellular protein localization Source: UniProtKB
- cellular response to amino acid stimulus Source: FlyBase
- positive regulation of TOR signaling Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-DME-1632852, Macroautophagy R-DME-165159, MTOR signalling R-DME-166208, mTORC1-mediated signalling R-DME-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-DME-5628897, TP53 Regulates Metabolic Genes R-DME-5674135, MAP2K and MAPK activation R-DME-6798695, Neutrophil degranulation R-DME-8943724, Regulation of PTEN gene transcription R-DME-9639288, Amino acids regulate mTORC1 |
Names & Taxonomyi
Protein namesi | Recommended name: Ragulator complex protein LAMTOR3 homologAlternative name(s): Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3 |
Gene namesi | ORF Names:CG5110 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0032642, CG5110 |
Subcellular locationi
Endosome
- Ragulator complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221007 | 1 – 124 | Ragulator complex protein LAMTOR3 homologAdd BLAST | 124 |
Proteomic databases
PaxDbi | Q9VJD2 |
PRIDEi | Q9VJD2 |
Expressioni
Gene expression databases
Bgeei | FBgn0032642, Expressed in head and 40 other tissues |
ExpressionAtlasi | Q9VJD2, baseline and differential |
Genevisiblei | Q9VJD2, DM |
Interactioni
Subunit structurei
Part of the Ragulator complex composed of CG5110, CG5189, CG14184, CG14812, and CG14977.
By similarityProtein-protein interaction databases
BioGRIDi | 61051, 5 interactors |
DIPi | DIP-17874N |
IntActi | Q9VJD2, 2 interactors |
STRINGi | 7227.FBpp0297292 |
Family & Domainsi
Sequence similaritiesi
Belongs to the LAMTOR3 family.Curated
Phylogenomic databases
eggNOGi | ENOG502RYGZ, Eukaryota |
GeneTreei | ENSGT00390000013159 |
HOGENOMi | CLU_134641_0_0_1 |
InParanoidi | Q9VJD2 |
OMAi | YQVIQMN |
OrthoDBi | 1525606at2759 |
PhylomeDBi | Q9VJD2 |
Family and domain databases
InterProi | View protein in InterPro IPR015019, LAMTOR3 |
PANTHERi | PTHR13378, PTHR13378, 1 hit |
Pfami | View protein in Pfam PF08923, MAPKK1_Int, 1 hit |
SMARTi | View protein in SMART SM01278, MAPKK1_Int, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9VJD2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDDIKKYLD GLLQKVSGLY VIQITDRDGV PLLRVSQEKN VDFALMPSFI
60 70 80 90 100
PTFTTACDQA SKLGLGRNKT IISMYSNYQV VQMNKLPLIL TFVGAENCNT
110 120
GHILALEHQV DGYLEDIKQA VTEA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9NEQ5 | M9NEQ5_DROME | GEO07317p1 | dMP1 BcDNA:RE09173, Dmel\CG5110, MP1, CG5110, Dmel_CG5110 | 124 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53620.1 AY071010 mRNA Translation: AAL48632.1 |
RefSeqi | NP_001246062.1, NM_001259133.2 NP_609843.1, NM_135999.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0080983; FBpp0080536; FBgn0032642 FBtr0306162; FBpp0297292; FBgn0032642 |
GeneIDi | 35055 |
KEGGi | dme:Dmel_CG5110 |
UCSCi | CG5110-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53620.1 AY071010 mRNA Translation: AAL48632.1 |
RefSeqi | NP_001246062.1, NM_001259133.2 NP_609843.1, NM_135999.4 |
3D structure databases
SMRi | Q9VJD2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 61051, 5 interactors |
DIPi | DIP-17874N |
IntActi | Q9VJD2, 2 interactors |
STRINGi | 7227.FBpp0297292 |
Proteomic databases
PaxDbi | Q9VJD2 |
PRIDEi | Q9VJD2 |
Genome annotation databases
EnsemblMetazoai | FBtr0080983; FBpp0080536; FBgn0032642 FBtr0306162; FBpp0297292; FBgn0032642 |
GeneIDi | 35055 |
KEGGi | dme:Dmel_CG5110 |
UCSCi | CG5110-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0032642, CG5110 |
Phylogenomic databases
eggNOGi | ENOG502RYGZ, Eukaryota |
GeneTreei | ENSGT00390000013159 |
HOGENOMi | CLU_134641_0_0_1 |
InParanoidi | Q9VJD2 |
OMAi | YQVIQMN |
OrthoDBi | 1525606at2759 |
PhylomeDBi | Q9VJD2 |
Enzyme and pathway databases
Reactomei | R-DME-1632852, Macroautophagy R-DME-165159, MTOR signalling R-DME-166208, mTORC1-mediated signalling R-DME-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-DME-5628897, TP53 Regulates Metabolic Genes R-DME-5674135, MAP2K and MAPK activation R-DME-6798695, Neutrophil degranulation R-DME-8943724, Regulation of PTEN gene transcription R-DME-9639288, Amino acids regulate mTORC1 |
Miscellaneous databases
BioGRID-ORCSi | 35055, 0 hits in 1 CRISPR screen |
GenomeRNAii | 35055 |
PROi | PR:Q9VJD2 |
Gene expression databases
Bgeei | FBgn0032642, Expressed in head and 40 other tissues |
ExpressionAtlasi | Q9VJD2, baseline and differential |
Genevisiblei | Q9VJD2, DM |
Family and domain databases
InterProi | View protein in InterPro IPR015019, LAMTOR3 |
PANTHERi | PTHR13378, PTHR13378, 1 hit |
Pfami | View protein in Pfam PF08923, MAPKK1_Int, 1 hit |
SMARTi | View protein in SMART SM01278, MAPKK1_Int, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LTOR3_DROME | |
Accessioni | Q9VJD2Primary (citable) accession number: Q9VJD2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families