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Entry version 161 (17 Jun 2020)
Sequence version 3 (14 May 2014)
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Protein

Putative neural-cadherin 2

Gene

CadN2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1474228 Degradation of the extracellular matrix
R-DME-216083 Integrin cell surface interactions
R-DME-351906 Apoptotic cleavage of cell adhesion proteins
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-418990 Adherens junctions interactions
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-525793 Myogenesis
R-DME-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative neural-cadherin 2
Alternative name(s):
Cadherin-N2
Short name:
dN2-cadherin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CadN2
ORF Names:CG42829, CG7527
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0262018 CadN2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1549 – 1569HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000038831 – 1799Putative neural-cadherin 2Add BLAST1799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi793N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi910N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi969N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi977 ↔ 988By similarity
Disulfide bondi982 ↔ 997By similarity
Disulfide bondi1000 ↔ 1009By similarity
Disulfide bondi1191 ↔ 1217By similarity
Disulfide bondi1224 ↔ 1239By similarity
Disulfide bondi1233 ↔ 1248By similarity
Disulfide bondi1250 ↔ 1259By similarity
Glycosylationi1376N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1419 ↔ 1454By similarity
Glycosylationi1437N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1501 ↔ 1512By similarity
Disulfide bondi1506 ↔ 1523By similarity
Disulfide bondi1525 ↔ 1534By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VJB6

PRoteomics IDEntifications database

More...
PRIDEi
Q9VJB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0262018 Expressed in head and 4 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VJB6 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
61067, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9VJB6, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0300935

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VJB6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 136Cadherin 1PROSITE-ProRule annotationAdd BLAST100
Domaini137 – 252Cadherin 2PROSITE-ProRule annotationAdd BLAST116
Domaini253 – 364Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini368 – 485Cadherin 4PROSITE-ProRule annotationAdd BLAST118
Domaini486 – 590Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini590 – 709Cadherin 6PROSITE-ProRule annotationAdd BLAST120
Domaini708 – 812Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini973 – 1010EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini1011 – 1217Laminin G-like 1PROSITE-ProRule annotationAdd BLAST207
Domaini1220 – 1260EGF-like 2PROSITE-ProRule annotationAdd BLAST41
Domaini1263 – 1454Laminin G-like 2PROSITE-ProRule annotationAdd BLAST192
Domaini1497 – 1535EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219 Eukaryota
ENOG410XPEI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000173178

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000347_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VJB6

Identification of Orthologs from Complete Genome Data

More...
OMAi
HREYAIL

Database of Orthologous Groups

More...
OrthoDBi
6237at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.900.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PF00008 EGF, 1 hit
PF12661 hEGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 6 hits
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 7 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 4 hits
PS50268 CADHERIN_2, 7 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VJB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDPLKIFWV LTNSTYLVTK FVRIGIADKN DSPPYFDRFL YETEIDENAD
60 70 80 90 100
LQSTVLTVNA KDHNESTNIR YQITGGNIGN AFAVQNTTGV IYVASPLDYE
110 120 130 140 150
TRPRYELRLE ATRNRKNNYT TVVINVRDVN DNPPVFDRQT YRTQITEEDD
160 170 180 190 200
RNLPKRILQV TATDGDVDRP INIVYFLTGQ GIDPDNPANS KFDINRTTGD
210 220 230 240 250
IFVLKPLDRD QPNGRPQWRF TVFAQDEGGE GLVGYADIQV NLKDINDNAP
260 270 280 290 300
QFPQGIYFGN VTENGTAGSS VMTMSAVDYD DPNESTNAKL IYSIEKNVIE
310 320 330 340 350
EETGAPIFEI EPETGLIKTA VCCLDRERTP DYSIQVVAMD GGGLKGTGTA
360 370 380 390 400
SIRVKDLNDM PPQFTKDEWV TEVDETNGTY IPETPILTVT VQDEDETNTF
410 420 430 440 450
QYKVVPNSGF GADKFAMVRN GDGTGSLKII QPLDYEDPLQ SSGFRFRIQV
460 470 480 490 500
NDKGDDGPGG SDKYHVAYSW VVVKLRDIND NVPKFDREHI EVSIYEDTKV
510 520 530 540 550
GTILEQFKAT DADQGGHSKV AYKIVRSTNR KRQFAISDRG AVSIQRPLDR
560 570 580 590 600
ETQDRHHIQI LAIDDGSPAR TATATLTVIV KDVNDNAPTF AQDYKPTLPE
610 620 630 640 650
NVSGKKILEV AAKDPDDRLR GNGGPFTFRL DPLASDEIKA GFKVEYDRRG
660 670 680 690 700
DNENGVAIIS SLRPFDREAQ KSYAIPIEIK DNGAPAMTGT STLTVTIGDV
710 720 730 740 750
NDNKMQPGSK SVLVYNYQGQ SQDTPIGRVY VNDPDDWDVP DKKYYWEVQE
760 770 780 790 800
HQRFKLDTDT GILTMRAGTR RGRYQLRFKV YDREHGQEDI PANLSVTVRD
810 820 830 840 850
ITAEAVQQAG SMRLSHITDE DFVRTWNPVK NQVEPSKLER FRNKLAELLY
860 870 880 890 900
TDRDNVDVFS VQLKEGSPYP LTDVHFAARS ATQQPYFKAV RLNGVVQMHR
910 920 930 940 950
EEIEKDVGLN ITMVNINECL HEGKGKCGSN SCTSKVELGK KPYTVSVNRT
960 970 980 990 1000
ALVGVRLDIS AQCVCRARNF THQDHNCRTH LCYNGGRCVE TRNGPKCVAC
1010 1020 1030 1040 1050
PVGYNGPRCQ QSTRSFRGNG WAWYPPLQLC QESHLSLEFI TRVADGLILY
1060 1070 1080 1090 1100
NGPIVPPKPE ETVISDFIAL ELEQGYPRLL IDFGSGTLEL RVKTKKTLDD
1110 1120 1130 1140 1150
GVWHRLDIFW DTENVRMVVD FCRTALVSEM EDGTPPEFDD NACQARGQIP
1160 1170 1180 1190 1200
PFAESLNLNQ PLQLGGLYRQ HFDQTLYNWQ YAFSSKGFDG CIRNVIHNSE
1210 1220 1230 1240 1250
HYDLAFPALA RNSFPACPQT DEVCLKTEHT ARCWEHGNCV ASLVQAKCHC
1260 1270 1280 1290 1300
QPGWMGPGCN VPTIPTTFKA QSYVKFALSF EPDRFSTQLQ LRFRTREQGG
1310 1320 1330 1340 1350
ELFRVSDQHH REYAILELRR GHLQFRYNLN SMRNEEQLLT LTAIAVNDGQ
1360 1370 1380 1390 1400
WHVIRISRYG SAALMELDGG ESRRYNESFH FTGHQWLTID KQEGVYAGGK
1410 1420 1430 1440 1450
AEYTGIKTFE VQSDFQRSCL DDIRLDGKHL PLPPAMNGTQ WGQATMARNL
1460 1470 1480 1490 1500
ERNCPSNRPC SNVICPDPFD CVDLWNEYEC TCSEGRIMSS DTKGCVDRNE
1510 1520 1530 1540 1550
CLDLPCLNGA TCINLEPRLR YRCICPEGYW GENCELVQEG QRLKLSMGAL
1560 1570 1580 1590 1600
GAIFVCLIII LILALIFVLY SRKRKTTKKK KRSGPEKDVR ETVISYEDEG
1610 1620 1630 1640 1650
GGEDDMTAFD ITPLQIPISA QGGPPDIAAC KMPIIYPVMT LLPPGQELNV
1660 1670 1680 1690 1700
AYLMEERKQR IDKDNNAPPF DDLRNFTFEG SGSIAESLSS LASGTDDENQ
1710 1720 1730 1740 1750
DFNYLQNWGP RFNALAAMYV HDKAKASSQL PSDGGGGSGD GPGPGASSSS
1760 1770 1780 1790
PLGGGGTGGG SGIPGNVLAV VATGSGAGPG GGGGSSGLMP LPEVDKVVL
Length:1,799
Mass (Da):200,480
Last modified:May 14, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6ECD9723887BCAF6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53636.4
AE014134 Genomic DNA Translation: ABI31322.2
BT132666 mRNA Translation: AEQ05568.1

NCBI Reference Sequences

More...
RefSeqi
NP_001036368.2, NM_001042903.4
NP_609855.3, NM_136011.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0303836; FBpp0292843; FBgn0262018
FBtr0308770; FBpp0300935; FBgn0262018

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35071

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG42829

UCSC genome browser

More...
UCSCi
CG7527-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53636.4
AE014134 Genomic DNA Translation: ABI31322.2
BT132666 mRNA Translation: AEQ05568.1
RefSeqiNP_001036368.2, NM_001042903.4
NP_609855.3, NM_136011.4

3D structure databases

SMRiQ9VJB6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi61067, 1 interactor
IntActiQ9VJB6, 6 interactors
STRINGi7227.FBpp0300935

Proteomic databases

PaxDbiQ9VJB6
PRIDEiQ9VJB6

Genome annotation databases

EnsemblMetazoaiFBtr0303836; FBpp0292843; FBgn0262018
FBtr0308770; FBpp0300935; FBgn0262018
GeneIDi35071
KEGGidme:Dmel_CG42829
UCSCiCG7527-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
35071
FlyBaseiFBgn0262018 CadN2

Phylogenomic databases

eggNOGiKOG1219 Eukaryota
ENOG410XPEI LUCA
GeneTreeiENSGT00940000173178
HOGENOMiCLU_000347_0_1_1
InParanoidiQ9VJB6
OMAiHREYAIL
OrthoDBi6237at2759

Enzyme and pathway databases

ReactomeiR-DME-1474228 Degradation of the extracellular matrix
R-DME-216083 Integrin cell surface interactions
R-DME-351906 Apoptotic cleavage of cell adhesion proteins
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-418990 Adherens junctions interactions
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-525793 Myogenesis
R-DME-8957275 Post-translational protein phosphorylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35071 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35071

Protein Ontology

More...
PROi
PR:Q9VJB6

Gene expression databases

BgeeiFBgn0262018 Expressed in head and 4 other tissues
GenevisibleiQ9VJB6 DM

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PF00008 EGF, 1 hit
PF12661 hEGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SM00181 EGF, 4 hits
SM00179 EGF_CA, 4 hits
SM00282 LamG, 2 hits
SUPFAMiSSF49313 SSF49313, 7 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 4 hits
PS50268 CADHERIN_2, 7 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCADN2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VJB6
Secondary accession number(s): G4LU36, Q0E8P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 14, 2014
Last modified: June 17, 2020
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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