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Entry version 180 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

Receptor protein-tyrosine kinase

Gene

Dmel\CG10702

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109704, PI3K Cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-1433559, Regulation of KIT signaling
R-DME-186763, Downstream signal transduction
R-DME-186797, Signaling by PDGF
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-9607240, FLT3 Signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseARBA annotation (EC:2.7.10.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG10702Imported
ORF Names:CG10702Imported, Dmel_CG10702Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0032752, CG10702

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0032752

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei870 – 890HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501510030125 – 946Receptor protein-tyrosine kinaseSequence analysisAdd BLAST922

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0032752, Expressed in embryo and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VJ04, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080716

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 158Recep_L_domainInterPro annotationAdd BLAST112
Domaini179 – 306Furin-likeInterPro annotationAdd BLAST128
Domaini328 – 433Recep_L_domainInterPro annotationAdd BLAST106

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4258, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_311983_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RNNKLCN

Database of Orthologous Groups

More...
OrthoDBi
223327at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VJ04

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00064, FU, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.20.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036116, FN3_sf
IPR006211, Furin-like_Cys-rich_dom
IPR006212, Furin_repeat
IPR009030, Growth_fac_rcpt_cys_sf
IPR000494, Rcpt_L-dom
IPR036941, Rcpt_L-dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00757, Furin-like, 1 hit
PF01030, Recep_L_domain, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00261, FU, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits
SSF57184, SSF57184, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VJ04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHCGNMLLGV GLMFLALYVP CAESKKEHEC TSIDIRNECK NMHLLDNCTV
60 70 80 90 100
VTGYVMITLI TIEQRCNFSE YSYPLLTEIT EFMIFTDVRG LVNITEMFPH
110 120 130 140 150
LTVIRGRRLF LNYALGVTNM HELEQLVFPK LVAIQRGQVY IGSCPKLCSI
160 170 180 190 200
GRVNWDLLTL TRGENNIIMV NKNCSTPVCS GCSSSHCWSN HYCQRSINEN
210 220 230 240 250
VANPKANINA CHEECLGGCK NNSSSPADCS VCRGLSDDGV CVKSCPKDKY
260 270 280 290 300
VMENYQRCYT KAECVLKHGY VISGSQCVAF CPSGYKTNNR SECVLCSPDE
310 320 330 340 350
ACISFCTPEW PGKAFTVYNL ADAENLRGCQ IFNGSLVITI RNKVNETQLY
360 370 380 390 400
QSFTSMREVR GHVKVYRSSQ LRSLQFLRNL ERVHGDPLEN RHYSFILYDN
410 420 430 440 450
KELSELWTPS RQLEFMEGGM FMHRNNKLCN RRMREFQNAV THDRALDSLQ
460 470 480 490 500
TNDQEVQCSP LKLQLYVQKR THRSVKLSWL KSQTSQKIEL IHRPLLPGKL
510 520 530 540 550
YHEESELDAP ICTRINWKRR LLFPDDLIEN GTHYLFDLDD LQPDTRYVVL
560 570 580 590 600
LRTFGNDEAH EAYEARSELT YVQTELDIPK PPLLELVKKT DSSLTVQMAS
610 620 630 640 650
HDHVSFLLTV FELSDDQDYI EQRNYCHQPS YVWQDMDGPR WMAYEDYDDC
660 670 680 690 700
CAQKAEQFED SRFIADMREQ YRCTLDDREQ CRRLAHTEVS LPQLRLPGNT
710 720 730 740 750
TEYELKALHR YRLYALQLQA CNPLGCSSHT TLYGRTNYTM GADLLTQLYA
760 770 780 790 800
CHIPEMDKYI MRFEEPKKPN GLVTNYVIHF RNNFSQTHVG CVTRMDHQSA
810 820 830 840 850
GYMYVKQINI TFTECAVRVH SLAGDVMTPY MPISLCSDED RLQAFHSREA
860 870 880 890 900
KDLSPEITDL PATASHGRGI SIFLICFLFG CSVSLVWVLY KRRCWRKLPG
910 920 930 940
LRRYVPVREQ WLRDRQQTED REILVDGFET VRFQNNNNSQ ADDYPM
Length:946
Mass (Da):109,382
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFFC0E8B91B79125
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53753.1
AY122177 mRNA Translation: AAM52689.1
AE014134 Genomic DNA Translation: AAN11024.1
AE014134 Genomic DNA Translation: AAN11025.1
AE014134 Genomic DNA Translation: ADV37090.1

NCBI Reference Sequences

More...
RefSeqi
NP_001188841.1, NM_001201912.2
NP_724157.1, NM_165274.3
NP_724158.1, NM_165275.2
NP_724159.1, NM_165276.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081174; FBpp0080716; FBgn0032752
FBtr0081175; FBpp0080717; FBgn0032752
FBtr0081176; FBpp0080718; FBgn0032752
FBtr0303241; FBpp0292333; FBgn0032752

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35181

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG10702

UCSC genome browser

More...
UCSCi
CG10702-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53753.1
AY122177 mRNA Translation: AAM52689.1
AE014134 Genomic DNA Translation: AAN11024.1
AE014134 Genomic DNA Translation: AAN11025.1
AE014134 Genomic DNA Translation: ADV37090.1
RefSeqiNP_001188841.1, NM_001201912.2
NP_724157.1, NM_165274.3
NP_724158.1, NM_165275.2
NP_724159.1, NM_165276.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0080716

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
35181

Genome annotation databases

EnsemblMetazoaiFBtr0081174; FBpp0080716; FBgn0032752
FBtr0081175; FBpp0080717; FBgn0032752
FBtr0081176; FBpp0080718; FBgn0032752
FBtr0303241; FBpp0292333; FBgn0032752
GeneIDi35181
KEGGidme:Dmel_CG10702
UCSCiCG10702-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0032752, CG10702
VEuPathDBiVectorBase:FBgn0032752

Phylogenomic databases

eggNOGiKOG4258, Eukaryota
GeneTreeiENSGT00940000171611
HOGENOMiCLU_311983_0_0_1
OMAiRNNKLCN
OrthoDBi223327at2759
PhylomeDBiQ9VJ04

Enzyme and pathway databases

ReactomeiR-DME-109704, PI3K Cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-1433559, Regulation of KIT signaling
R-DME-186763, Downstream signal transduction
R-DME-186797, Signaling by PDGF
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-9607240, FLT3 Signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35181, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35181

Gene expression databases

BgeeiFBgn0032752, Expressed in embryo and 37 other tissues
ExpressionAtlasiQ9VJ04, baseline and differential

Family and domain databases

CDDicd00064, FU, 1 hit
Gene3Di3.80.20.20, 2 hits
InterProiView protein in InterPro
IPR036116, FN3_sf
IPR006211, Furin-like_Cys-rich_dom
IPR006212, Furin_repeat
IPR009030, Growth_fac_rcpt_cys_sf
IPR000494, Rcpt_L-dom
IPR036941, Rcpt_L-dom_sf
PfamiView protein in Pfam
PF00757, Furin-like, 1 hit
PF01030, Recep_L_domain, 2 hits
SMARTiView protein in SMART
SM00261, FU, 1 hit
SUPFAMiSSF49265, SSF49265, 2 hits
SSF57184, SSF57184, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VJ04_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VJ04
Secondary accession number(s): Q9VJ05
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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