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UniProtKB - Q9VIF5 (DEL_DROME)

Entry version 133 (25 May 2022)
Sequence version 2 (01 Oct 2002)
Previous versions | rss
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Protein

Protein deadlock

Gene

del

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Developmental protein involved in oogenesis (PubMed:16616913).

Required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females (PubMed:16616913).

Also required for dorso-ventral and antero-posterior patterning of oocyte and eggshell (PubMed:16616913).

May be involved in microtubule function during oogenesis (PubMed:16616913).

Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers (PubMed:28847004).

Component of the RDC complex (rhi, del and cuff) which binds to repressive H3K9me3 marks in the piRNA clusters (PubMed:28847004).

RDC promotes the bidirectional transcription of piRNA clusters at these sites by interacting with Moonshiner which forms a complex with the transcription initiation factors TfIIA-S and Trf2 (PubMed:28847004).

This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark (PubMed:28847004).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Oogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9VIF5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein deadlock
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:del
ORF Names:CG9252
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0086251, del

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0086251

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002352961 – 981Protein deadlockAdd BLAST981

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VIF5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0086251, Expressed in female gonad and 30 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VIF5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VIF5, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		61335, 8 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3213, Rhino-Deadlock-Cutoff Complex

Protein interaction database and analysis system

More...IntActi		Q9VIF5, 6 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0305298

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1981
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9VIF5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VIF5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 195DisorderedSequence analysisAdd BLAST124
Regioni274 – 307DisorderedSequence analysisAdd BLAST34
Regioni327 – 352DisorderedSequence analysisAdd BLAST26
Regioni375 – 446DisorderedSequence analysisAdd BLAST72
Regioni554 – 586DisorderedSequence analysisAdd BLAST33
Regioni642 – 662DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi98 – 159Polar residuesSequence analysisAdd BLAST62
Compositional biasi160 – 192Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi333 – 351Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi398 – 413Polar residuesSequence analysisAdd BLAST16
Compositional biasi419 – 446Polar residuesSequence analysisAdd BLAST28
Compositional biasi559 – 574Basic and acidic residuesSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502T86W, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VIF5

Database of Orthologous Groups

More...OrthoDBi		482084at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VIF5

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9VIF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLDKIRMS QKLSCWQHIL TTLGTSSKTE QEWNTFFKGF LESWRKPYCI 
        60         70         80         90        100
QTSCDPSIPL RKELLVRPRK ALQENPHGPG STLPESPVFL EPINSTAPRE 
       110        120        130        140        150
HPSPSKSHST GSTGCDPGNG ERSPSVSNKN SKYKNPGNSK YAKIWKRSNN 
       160        170        180        190        200
HTTSIFSKAQ ISKRRDKLSS TKKRPDTCAP TDDSRKNREP RACAPNKNIF 
       210        220        230        240        250
KTRETNAPNL TKNSCALPNV LILSPNSASK ITQRGHSVGQ TQDYKASPGK 
       260        270        280        290        300
IIKRVPRYSL QCLKKKTEKV HNKIMDKPKN KQQPQTPPPF LLNNEYTESS 
       310        320        330        340        350
DDSDDQLPLS ELSQKMKSNK LNTLFLSRNE DCSPAPEKVK LKGERPAQNK 
       360        370        380        390        400
KEQLTWEPSI LTNLTDLGKQ VAEPLRKSVK KSAKQQKPRV RAPPQGKKTL 
       410        420        430        440        450
PQLQTGLKTQ DKQSTHEMIS EQAKTISEAS GQQTSQVQSS LSPNNIRNNS 
       460        470        480        490        500
VKLISAKTLM PAQRSQDYSP NKMQVGQPLG FAIELPSPVD GKEASVEIDT 
       510        520        530        540        550
QLVHTSKFLE NMTRPSTVEV HKFDLMDIFM GENEKLDYEY DDDDVLSVAA 
       560        570        580        590        600
SWNGLDDENV PEDEPRKEAK TAEQLPKPEP STETLKPIEK ENAQKMQSIK 
       610        620        630        640        650
SFQIPKLNAK NLKTQPSVMR SIYENEELEK NKVLAKPAPP SLVHQPLAES 
       660        670        680        690        700
NRNQRDEATA ARRAKETFPV FAPLYRVAPE SAATLVSANS QQVIPQVYFS 
       710        720        730        740        750
TSNQDGVNWI KDVFGIRCMQ SVDNKCISIN CDHTMNSLGE VQKRLMRMDE 
       760        770        780        790        800
DTLLSLYRQT IRSFFLFQTY YTSFVDIFKF RNLWQYLLIM LVDCRLYKSI 
       810        820        830        840        850
SAPLLAHVYE ALSKCGMQKE AVKRIMEHVW LPCKAHKYRD LMLTTLNILS 
       860        870        880        890        900
NANWEDYCDK LTQLDKDYNF EIPHKNLITI LKSSVDCSDK FANALKLITL 
       910        920        930        940        950
HPNSIRTNET IMSILSNASK SYSYMHNESA SASQGPPGAA SFLAPPAAIQ 
       960        970        980 
PPHTTVPNFG YLPNPSFHYS NEYAINIHNF D
Length:981
Mass (Da):110,817
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A825881240BDC1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PDK1M9PDK1_DROME
Deadlock, isoform C
del Del, Dmel\CG9252, CG9252, Dmel_CG9252
981Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PDW9M9PDW9_DROME
Deadlock, isoform B
del Del, Dmel\CG9252, CG9252, Dmel_CG9252
978Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO39437 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53964.2
BT003434 mRNA Translation: AAO39437.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_001260666.1, NM_001273737.1
NP_610091.2, NM_136247.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0081502; FBpp0081030; FBgn0086251
FBtr0333085; FBpp0305298; FBgn0086251

Database of genes from NCBI RefSeq genomes

More...GeneIDi		35380

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG9252

UCSC genome browser

More...UCSCi		CG9252-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53964.2
BT003434 mRNA Translation: AAO39437.1 Different initiation.
RefSeqiNP_001260666.1, NM_001273737.1
NP_610091.2, NM_136247.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XYVX-ray2.10C/D1-60[»]
AlphaFoldDBiQ9VIF5
SMRiQ9VIF5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi61335, 8 interactors
ComplexPortaliCPX-3213, Rhino-Deadlock-Cutoff Complex
IntActiQ9VIF5, 6 interactors
STRINGi7227.FBpp0305298

Proteomic databases

PaxDbiQ9VIF5

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		35380

Genome annotation databases

EnsemblMetazoaiFBtr0081502; FBpp0081030; FBgn0086251
FBtr0333085; FBpp0305298; FBgn0086251
GeneIDi35380
KEGGidme:Dmel_CG9252
UCSCiCG9252-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		35380
FlyBaseiFBgn0086251, del
VEuPathDBiVectorBase:FBgn0086251

Phylogenomic databases

eggNOGiENOG502T86W, Eukaryota
InParanoidiQ9VIF5
OrthoDBi482084at2759
PhylomeDBiQ9VIF5

Enzyme and pathway databases

SignaLinkiQ9VIF5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		35380, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		35380

Protein Ontology

More...PROi		PR:Q9VIF5

Gene expression databases

BgeeiFBgn0086251, Expressed in female gonad and 30 other tissues
ExpressionAtlasiQ9VIF5, baseline and differential
GenevisibleiQ9VIF5, DM

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEL_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VIF5
Secondary accession number(s): Q86P81
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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