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UniProtKB - Q9VIE7 (Q9VIE7_DROME)

Entry version 184 (07 Apr 2021)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

Glutamine amidotransferase

Gene

bur

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).ARBA annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glutamine amidotransferase (bur), Glutamine amidotransferase (bur)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei95NucleophilePROSITE-ProRule annotation1
Active sitei182PROSITE-ProRule annotation1
Active sitei184PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi236 – 242ATPPROSITE-ProRule annotation7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported, LigaseImported
Biological processGMP biosynthesisPROSITE-ProRule annotationARBA annotation, Purine biosynthesis
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-73817, Purine ribonucleoside monophosphate biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00189;UER00296

Protein family/group databases

MEROPS protease database

More...MEROPSi		C26.A21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamine amidotransferaseARBA annotation (EC:6.3.5.2ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:burImported
Synonyms:anon-WO0118547.193Imported, anon-WO0118547.204Imported, BurImported, Dmel\CG9242Imported, ES2-2Imported, GMPSImported, GmpsImported, gua2Imported, l(2)10523Imported, P174Imported
ORF Names:CG9242Imported, Dmel_CG9242Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0000239, bur

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q9VIE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0000239, Expressed in embryo and 37 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9VIE7, 5 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0290556

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VIE7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 208Glutamine amidotransferase type-1InterPro annotationAdd BLAST191
Domaini209 – 424GMPS ATP-PPaseInterPro annotationAdd BLAST216

Keywords - Domaini

Glutamine amidotransferasePROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1622, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014340_0_2_1

Identification of Orthologs from Complete Genome Data

More...OMAi		KRKIIGH

Database of Orthologous Groups

More...OrthoDBi		392369at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd01742, GATase1_GMP_Synthase, 1 hit
cd01997, GMP_synthase_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.620, 1 hit
3.40.50.880, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029062, Class_I_gatase-like
IPR017926, GATASE
IPR001674, GMP_synth_C
IPR004739, GMP_synth_GATase
IPR025777, GMPS_ATP_PPase_dom
IPR022310, NAD/GMP_synthase
IPR014729, Rossmann-like_a/b/a_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00117, GATase, 1 hit
PF00958, GMP_synt_C, 2 hits
PF02540, NAD_synthase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52317, SSF52317, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00888, guaA_Nterm, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit
PS51553, GMPS_ATP_PPASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VIE7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSNIFLGTA ENGLRHDKIV ILDAGAQYGK VIDRKVRELF VETDILPLDT 
        60         70         80         90        100
PAATIRNNGY RGIIISGGPN SVYAEDAPSY DPDLFKLKIP MLGICYGMQL 
       110        120        130        140        150
INKEFGGTVL KKDVREDGQQ NIEIETSCPL FSRLSRTQSV LLTHGDSVER 
       160        170        180        190        200
VGENLKIGGW STNRIVTAIY NEVLRIYGVQ FHPEVDLTIN GKQMLSNFLY 
       210        220        230        240        250
EICELTPNFT MGSRKEECIR YIREKVGNNK VLLLVSGGVD SSVCAALLRR 
       260        270        280        290        300
ALYPHQIIAV HVDNGFMRKK ESEKVERSLR DIGIDLIVRK EGYTFLKGTT 
       310        320        330        340        350
QVKRPGQYSV VETPMLCQTY NPEEKRKIIG DIFVKVTNDV VAELKLKPEE 
       360        370        380        390        400
VMLAQGTLRP DLIESASSMV STNAETIKTH HNDTDLIREL RNAGRVVEPL 
       410        420        430        440        450
CDFHKDEVRD LGNDLGLPQE LVERQPFPGP GLAIRVLCAE EAYMEKDYSE 
       460        470        480        490        500
TQVIIRVIVD YKNKLQKNHA LINRVTAATS EAEQKDLMRI SSNSQIQATL 
       510        520        530        540        550
LPIRSVGVQG DKRSYSYVVG LSTSQEPNWQ DLLFLAKIIP RILHNVNRVC 
       560        570        580        590        600
YIFGEPVQYL VTDITHTTLN TVVLSQLRQA DDIANEIIMQ AGLYRKISQM 
       610        620        630        640        650
PVVLIPVHFD RDPINRTPSC RRSVVLRPFI TNDFMTGVPA EPGSVQMPLQ 
       660        670        680 
VLNQIVRDIS KLDGISRVLY DLTAKPPGTT EWE
Length:683
Mass (Da):76,790
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1AB55AD9DEF8CB4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53975.3
AY118572 mRNA Translation: AAM49941.1
AE014134 Genomic DNA Translation: AHN54634.1

NCBI Reference Sequences

More...RefSeqi		NP_001286120.1, NM_001299191.1
NP_620114.3, NM_138759.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0301342; FBpp0290556; FBgn0000239
FBtr0343875; FBpp0310411; FBgn0000239

Database of genes from NCBI RefSeq genomes

More...GeneIDi		45830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG9242

UCSC genome browser

More...UCSCi		CG9242-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53975.3
AY118572 mRNA Translation: AAM49941.1
AE014134 Genomic DNA Translation: AHN54634.1
RefSeqiNP_001286120.1, NM_001299191.1
NP_620114.3, NM_138759.4

3D structure databases

SMRiQ9VIE7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9VIE7, 5 interactors
STRINGi7227.FBpp0290556

Protein family/group databases

MEROPSiC26.A21

Proteomic databases

PRIDEiQ9VIE7

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		45830

Genome annotation databases

EnsemblMetazoaiFBtr0301342; FBpp0290556; FBgn0000239
FBtr0343875; FBpp0310411; FBgn0000239
GeneIDi45830
KEGGidme:Dmel_CG9242
UCSCiCG9242-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		45830
FlyBaseiFBgn0000239, bur

Phylogenomic databases

eggNOGiKOG1622, Eukaryota
GeneTreeiENSGT00390000006591
HOGENOMiCLU_014340_0_2_1
OMAiKRKIIGH
OrthoDBi392369at2759

Enzyme and pathway databases

UniPathwayiUPA00189;UER00296
ReactomeiR-DME-73817, Purine ribonucleoside monophosphate biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		45830, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		45830

Gene expression databases

BgeeiFBgn0000239, Expressed in embryo and 37 other tissues

Family and domain databases

CDDicd01742, GATase1_GMP_Synthase, 1 hit
cd01997, GMP_synthase_C, 1 hit
Gene3Di3.40.50.620, 1 hit
3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR029062, Class_I_gatase-like
IPR017926, GATASE
IPR001674, GMP_synth_C
IPR004739, GMP_synth_GATase
IPR025777, GMPS_ATP_PPase_dom
IPR022310, NAD/GMP_synthase
IPR014729, Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00117, GATase, 1 hit
PF00958, GMP_synt_C, 2 hits
PF02540, NAD_synthase, 1 hit
SUPFAMiSSF52317, SSF52317, 1 hit
TIGRFAMsiTIGR00888, guaA_Nterm, 1 hit
PROSITEiView protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit
PS51553, GMPS_ATP_PPASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VIE7_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VIE7
Secondary accession number(s): Q8MSU9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: April 7, 2021
This is version 184 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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