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Entry version 136 (29 Sep 2021)
Sequence version 1 (01 May 2000)
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Protein

Nucleolar complex protein 3 homolog

Gene

CG1234

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar complex protein 3 homolog
Short name:
NOC3 protein homolog
Alternative name(s):
NOC3-like protein
Nucleolar complex-associated protein 3-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CG1234
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037489, CG1234

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0037489

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001734811 – 822Nucleolar complex protein 3 homologAdd BLAST822

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei187Phosphoserine1 Publication1
Modified residuei193Phosphothreonine1 Publication1
Modified residuei198Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9VI82

PRoteomics IDEntifications database

More...
PRIDEi
Q9VI82

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VI82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037489, Expressed in embryo and 52 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VI82, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66065, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VI82, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081117

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VI82

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 86DisorderedSequence analysisAdd BLAST86
Regioni106 – 142DisorderedSequence analysisAdd BLAST37
Regioni172 – 199DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili445 – 509Sequence analysisAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi182 – 199Acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2153, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008540

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012441_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VI82

Identification of Orthologs from Complete Genome Data

More...
OMAi
QKREFRT

Database of Orthologous Groups

More...
OrthoDBi
341721at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VI82

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR005612, CCAAT-binding_factor
IPR011501, Noc3_N
IPR016903, Nucleolar_cplx-assoc_3

The PANTHER Classification System

More...
PANTHERi
PTHR14428, PTHR14428, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03914, CBF, 1 hit
PF07540, NOC3p, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028977, Nucleolar_complex_p3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VI82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTKKVKISS VKRAAHLKSK KTPLSKQQQQ KQKQKRDQLK SKREQGQNIF
60 70 80 90 100
SQKARKRDNL AQRKKHNKLA SLGLDPLEED NEDGDDEMLE NVADMLDGDD
110 120 130 140 150
LALLQANKRK RKAKTTGEND PDQGQSIGLE RAYASDTKKE QDAQKIKLDL
160 170 180 190 200
LPIKSRDGQI ITRTTEVDYI PKPKQKKKNE EEEEDDSEED GDTEYEDSDD
210 220 230 240 250
DVVNDVEAAT AAPVQKLIST TDLLIARQQE IERQKYRIGI ICSGLLEKPE
260 270 280 290 300
DKMRNFHALY ELMDEINPAS RQANLMAVRK LAIISVTEIF KDILPEYRVG
310 320 330 340 350
QVDTKMQTLR KATLDRVTFE NALLQQFKKF LQKLEQITAQ VNRRGGLRTP
360 370 380 390 400
QTVKLATVAV QCMCDLLVAH PYFNYVQNIA QLLVYMLNCN YAEMRTAVHQ
410 420 430 440 450
CFRTVFSNDK RLEMTLFIVR RINHLIKTKQ NNVHVECITC LMGLKIKNVN
460 470 480 490 500
LDAEKENELK QKKLESHRQR LLSLSKKERK RRKKLTEVNR ELEETRAEEN
510 520 530 540 550
KQAKHQKLTE IIKMVFTIYF RVLKNDPTSR VLSAILEGLA EFAHVINLDF
560 570 580 590 600
FSDLIDVLNR ILEDQDELGY RERLHCVQTI FVILSGQGEV LNIDPIRFYQ
610 620 630 640 650
HFYRNMLAVQ AGKNHDDFAI ILRTLDEVLV KRRRNMSQQR LMAFMKRLLT
660 670 680 690 700
GSLHLLHNGT LATLGTIKQT FQLTSVLDNL LDTDTTIGSG RYDPELDDPE
710 720 730 740 750
YCNAASTALY ELALLARHYH PTVRRMAVHI AHGVPATGEG ALPTEIGKLT
760 770 780 790 800
SHELFTQFDS TQMAFNPTIP LPKAGQPKLK RGKHLYIRSD FKQEYGKLLQ
810 820
QGKVSQTKDK QTLQIDFFSA LQ
Length:822
Mass (Da):94,492
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6B724F9F83A4BC8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54043.1
AY051854 mRNA Translation: AAK93278.1

NCBI Reference Sequences

More...
RefSeqi
NP_649710.1, NM_141453.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081599; FBpp0081117; FBgn0037489

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1234

UCSC genome browser

More...
UCSCi
CG1234-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54043.1
AY051854 mRNA Translation: AAK93278.1
RefSeqiNP_649710.1, NM_141453.5

3D structure databases

SMRiQ9VI82
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi66065, 17 interactors
IntActiQ9VI82, 8 interactors
STRINGi7227.FBpp0081117

PTM databases

iPTMnetiQ9VI82

Proteomic databases

PaxDbiQ9VI82
PRIDEiQ9VI82

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
40870

Genome annotation databases

EnsemblMetazoaiFBtr0081599; FBpp0081117; FBgn0037489
GeneIDi40870
KEGGidme:Dmel_CG1234
UCSCiCG1234-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0037489, CG1234
VEuPathDBiVectorBase:FBgn0037489

Phylogenomic databases

eggNOGiKOG2153, Eukaryota
GeneTreeiENSGT00390000008540
HOGENOMiCLU_012441_2_0_1
InParanoidiQ9VI82
OMAiQKREFRT
OrthoDBi341721at2759
PhylomeDBiQ9VI82

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40870, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40870

Protein Ontology

More...
PROi
PR:Q9VI82

Gene expression databases

BgeeiFBgn0037489, Expressed in embryo and 52 other tissues
GenevisibleiQ9VI82, DM

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR005612, CCAAT-binding_factor
IPR011501, Noc3_N
IPR016903, Nucleolar_cplx-assoc_3
PANTHERiPTHR14428, PTHR14428, 1 hit
PfamiView protein in Pfam
PF03914, CBF, 1 hit
PF07540, NOC3p, 1 hit
PIRSFiPIRSF028977, Nucleolar_complex_p3, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOC3L_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VI82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 2000
Last modified: September 29, 2021
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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