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Entry version 142 (16 Oct 2019)
Sequence version 5 (01 Apr 2015)
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Protein
Submitted name:

Thawb

Gene

thw

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM14 Carbohydrate-Binding Module Family 14

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ThawbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:thwImported
Synonyms:Dmel\CG14608Imported
ORF Names:CG14608Imported, Dmel_CG14608Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037487 thw

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VI80

PRoteomics IDEntifications database

More...
PRIDEi
Q9VI80

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037487 Expressed in 11 organ(s), highest expression level in larva

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VI80 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0292311

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9VI80

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini109 – 166Chitin-binding type-2InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 394DisorderedSequence analysisAdd BLAST189
Regioni470 – 515DisorderedSequence analysisAdd BLAST46
Regioni619 – 648DisorderedSequence analysisAdd BLAST30
Regioni675 – 708DisorderedSequence analysisAdd BLAST34
Regioni755 – 774DisorderedSequence analysisAdd BLAST20
Regioni824 – 860DisorderedSequence analysisAdd BLAST37
Regioni907 – 928DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili540 – 560Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi254 – 285PolarSequence analysisAdd BLAST32
Compositional biasi319 – 358PolyampholyteSequence analysisAdd BLAST40
Compositional biasi360 – 394PolarSequence analysisAdd BLAST35
Compositional biasi475 – 509PolarSequence analysisAdd BLAST35
Compositional biasi630 – 645PolarSequence analysisAdd BLAST16
Compositional biasi684 – 708PolarSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZDJ Eukaryota
ENOG4111P12 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064666

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VI80

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPIYPRI

Database of Orthologous Groups

More...
OrthoDBi
94081at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VI80

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01607 CBM_14, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00494 ChtBD2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57625 SSF57625, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50940 CHIT_BIND_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VI80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLMPLKGNS KYKMRCTQLN LLCALIVLVI LGYTSAESKY RTPARILAKQ
60 70 80 90 100
TGATQFEEER YEAHTNCNEH KHHLKKRASD EDVDYEVYQG VVGRPGIDFP
110 120 130 140 150
IYPRIPKTSF SCRSYGNGYF ADMETDCQVF HICEEGRKIS FLCPNGTIFQ
160 170 180 190 200
QSELTCDWWF KVNCLGSSGY YAESAEILNK QRVHRVRPSV PVQGFNIVGG
210 220 230 240 250
GLNIKPKVTP VAGQGRSAAP RANPDRRIDS TEDVPASVES VDFDDVSGEK
260 270 280 290 300
QRKVLPSIDN NSNDQESQIT AESSSFVSGS GKRRTNKESN PNRNDDITVL
310 320 330 340 350
KPARLRTPVA TQERGVSTER ARNGQRGQHR YSGSEEHSKE RERPTPGQSK
360 370 380 390 400
EKPEFFEAHS TRSVPQTTAH YSTGSHSTVR RLEPSKSTPF YTPTVPSLVK
410 420 430 440 450
SKSTEGKLNY IKGGHVATTP NPHRFGSASS GIFIESSVAP KVKPTASASI
460 470 480 490 500
ELDSTFKPVI IGMRHHYDVA SSGEFRPPSK STESRDYLPT TPSPSAASSG
510 520 530 540 550
PTYLPMSGKS PRVNTGGAAG EDVLLFAPNP VKEESVFRNV QDMLKTMNLL
560 570 580 590 600
KDQFEDVELN AAAAAPARVG LEIPPSSGPD ALVSFAKYFA QEHNETINSL
610 620 630 640 650
SKKDKSEKVD KTGVQTKLSV KPPLPTIKPS DTTALLTTSE NPPAISDNAD
660 670 680 690 700
DIKKSLLSDT TVKKYSNLFG LKSAQGRGAG ESDISSGLLS NQTNGTQSEA
710 720 730 740 750
GSKYQQYPQI GSTGSTIGAL AEKPETRKIA QIFSNALSSY LDNPATFRAE
760 770 780 790 800
LAARARPTEP PSTPNFKPVT TTDPSLFSDG TAKYYLPTKG LPDATTPTPN
810 820 830 840 850
SIAAEINHKF DSTLAPEFST TTELYEGSTN RGLEFSGELS PPSQDSGEEF
860 870 880 890 900
LQQQQTQSFV KSRNDLLKDA RPQKLVTTHK PTEHPWALKS QTDFLDPLTI
910 920 930 940 950
NDGLMKEQRT STSSSTTSTS TTASPFAYRV TTPTPSRYEW EDIFRSYDIP
960 970 980 990 1000
RDALPSSSGL QRIANKLFGG LNEQEALHLR NVMAKAEHDR QVLSLLLLLI
1010 1020 1030 1040 1050
QTCDDHNGKA LERSRKHLLN ALIDIDSKTH AGGKTSRQRL TTTTNRIPVT
1060 1070 1080 1090 1100
TFRRGGAAAA EYFTSTTPGY TTTTDLPTTT GLGAGSYEET TKFEIRVEDL
1110 1120 1130
EEATTTTAPL LEVNSDRRAL ELLKSLYSLA SKFSSRR
Length:1,137
Mass (Da):124,587
Last modified:April 1, 2015 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31C03A68EB4023C3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54045.5

NCBI Reference Sequences

More...
RefSeqi
NP_001097699.2, NM_001104229.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0303219; FBpp0292311; FBgn0037487

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40868

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG14608

UCSC genome browser

More...
UCSCi
CG14608-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54045.5
RefSeqiNP_001097699.2, NM_001104229.3

3D structure databases

SMRiQ9VI80
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0292311

Protein family/group databases

CAZyiCBM14 Carbohydrate-Binding Module Family 14

Proteomic databases

PaxDbiQ9VI80
PRIDEiQ9VI80

Genome annotation databases

EnsemblMetazoaiFBtr0303219; FBpp0292311; FBgn0037487
GeneIDi40868
KEGGidme:Dmel_CG14608
UCSCiCG14608-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40868
FlyBaseiFBgn0037487 thw

Phylogenomic databases

eggNOGiENOG410IZDJ Eukaryota
ENOG4111P12 LUCA
GeneTreeiENSGT00530000064666
InParanoidiQ9VI80
OMAiFPIYPRI
OrthoDBi94081at2759
PhylomeDBiQ9VI80

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40868

Gene expression databases

BgeeiFBgn0037487 Expressed in 11 organ(s), highest expression level in larva
GenevisibleiQ9VI80 DM

Family and domain databases

InterProiView protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
PfamiView protein in Pfam
PF01607 CBM_14, 1 hit
SMARTiView protein in SMART
SM00494 ChtBD2, 1 hit
SUPFAMiSSF57625 SSF57625, 1 hit
PROSITEiView protein in PROSITE
PS50940 CHIT_BIND_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VI80_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VI80
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: April 1, 2015
Last modified: October 16, 2019
This is version 142 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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