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Entry version 135 (13 Feb 2019)
Sequence version 2 (05 Jul 2004)
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Protein
Submitted name:

Spindle assembly abnormal 4

Gene

Sas-4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein-containing complex scaffold activity Source: FlyBase
  • tubulin binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Spindle assembly abnormal 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sas-4Imported
Synonyms:CPAPImported, d-SAS-4Imported, D-Sas4Imported, D-sas4Imported, Dmel\CG10061Imported, DSAS-4Imported, DSas-4Imported, Dsas-4Imported, dsas-4Imported, DSas4Imported, Dsas4Imported, l(3)S2214Imported, l(3)s2214Imported, SAS-4Imported, sas-4Imported, SAS4Imported, Sas4Imported, sas4Imported
ORF Names:CG10061Imported, Dmel_CG10061Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011020 Sas-4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9VI72

PRoteomics IDEntifications database

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PRIDEi
Q9VI72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0011020 Expressed in 21 organ(s), highest expression level in eye disc (Drosophila)

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9VI72 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
aslQ9VNE42EBI-131879,EBI-108604

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9VI72, 11 interactors

Molecular INTeraction database

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MINTi
Q9VI72

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081088

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BY2X-ray2.57A/B/C700-901[»]
4MPZX-ray2.70A710-897[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9VI72

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9VI72

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini719 – 896Tcp10_CInterPro annotationAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili429 – 470Sequence analysisAdd BLAST42
Coiled coili500 – 595Sequence analysisAdd BLAST96

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEFU Eukaryota
ENOG4110DC4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063927

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VI72

KEGG Orthology (KO)

More...
KOi
K11502

Identification of Orthologs from Complete Genome Data

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OMAi
DIWYPNG

Database of Orthologous Groups

More...
OrthoDBi
204668at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VI72

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009852 Tcp10_C_dom
IPR026581 TCP10_fam

The PANTHER Classification System

More...
PANTHERi
PTHR10331 PTHR10331, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07202 Tcp10_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VI72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEAGESPVG MPLSQEAIAQ RLAALSRWQD EQKRLLQERQ SNHRVLLGLE
60 70 80 90 100
QRNMYKMLGL LHQETESHEN SVLEEWDEEH SIQMPRLAAD PDEHEPEISM
110 120 130 140 150
ADPQPAKPKR PFLRRGEGLK QRFKINPDQL RLENLPRYKF ANAHPQFRTP
160 170 180 190 200
QMKKGILKKQ VKSPPNPAPP PAPKPSAQLD DLNEQRFQQM LIGKNACSST
210 220 230 240 250
PDLKSSYASS TTASSTSPRV RFVEQKSRAG QTTHADDEAS SEASPMTGVC
260 270 280 290 300
WAKVLDTQSI KPAQIQRRSA QIRVEDDSNV SIFELLEQKA TEGNIDMNSS
310 320 330 340 350
CIRTFMARKD QRRRVADDSD HIVVTQQVRQ MRLQPQVDQM LVQELQEGDE
360 370 380 390 400
EDTEPSSDQT LTMTPIQVGN TKVRVRFSDS NDTHEYSDAT SLNDGSNIQL
410 420 430 440 450
FEQFKSALFQ ALEQKKKSSP SKESDEPITK DLQEKANLVR TRLEELETEI
460 470 480 490 500
ATFKEQNAQL LRLRQQHELE KAKCTQDHME AMERVHDEKI QAEIYLHDER
510 520 530 540 550
MKIEEERRKF EQQMRLQKSN ANSKEKKEIA ALKQEVEGLQ LQLKQKEQAH
560 570 580 590 600
VSAQARLRAQ LRASEKEQRN YRDEIELLRK ENKRLEQELV KIGRENNSKM
610 620 630 640 650
LQEINRNIAR LAPKVLPSAT MSDILDENGR RTQSLDGTAG KPAKQREAQN
660 670 680 690 700
RRQSSGSAQV RSRSRSLSRN KKTPYALDES YASSSSVESE EVQPPVTAPK
710 720 730 740 750
AATPPPAANS SSDFKREITN ADGSKDIWYP NGNLKKISAD GMNLRMLYFN
760 770 780 790 800
KDIKETNIRE GTVKYYYAET NTWHTSYLDG LEILEFPNGQ TEHRRKDGTV
810 820 830 840 850
EIHFPNNSIK IVDPSDTEKL EEWRYADGTH LVQLRNGDKI LNLPNGQKEI
860 870 880 890 900
HTKLNKRREY PDGTVKLVYP DGSQETRYSN GRVRLKDKDG KLIMDTDYAK

Y
Length:901
Mass (Da):103,283
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A0765CA0A92E492
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54053.2

NCBI Reference Sequences

More...
RefSeqi
NP_649701.2, NM_141444.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.17121

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081569; FBpp0081088; FBgn0011020

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40859

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG10061

UCSC genome browser

More...
UCSCi
CG10061-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54053.2
RefSeqiNP_649701.2, NM_141444.2
UniGeneiDm.17121

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BY2X-ray2.57A/B/C700-901[»]
4MPZX-ray2.70A710-897[»]
ProteinModelPortaliQ9VI72
SMRiQ9VI72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VI72, 11 interactors
MINTiQ9VI72
STRINGi7227.FBpp0081088

Proteomic databases

PaxDbiQ9VI72
PRIDEiQ9VI72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081569; FBpp0081088; FBgn0011020
GeneIDi40859
KEGGidme:Dmel_CG10061
UCSCiCG10061-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
40859
FlyBaseiFBgn0011020 Sas-4

Phylogenomic databases

eggNOGiENOG410IEFU Eukaryota
ENOG4110DC4 LUCA
GeneTreeiENSGT00530000063927
InParanoidiQ9VI72
KOiK11502
OMAiDIWYPNG
OrthoDBi204668at2759
PhylomeDBiQ9VI72

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40859

Protein Ontology

More...
PROi
PR:Q9VI72

Gene expression databases

BgeeiFBgn0011020 Expressed in 21 organ(s), highest expression level in eye disc (Drosophila)
GenevisibleiQ9VI72 DM

Family and domain databases

InterProiView protein in InterPro
IPR009852 Tcp10_C_dom
IPR026581 TCP10_fam
PANTHERiPTHR10331 PTHR10331, 1 hit
PfamiView protein in Pfam
PF07202 Tcp10_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VI72_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VI72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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