UniProtKB - Q9VHY5 (TAF7_DROME)
Protein
Transcription initiation factor TFIID subunit 7
Gene
Taf7
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
GO - Molecular functioni
- RNA polymerase II general transcription initiation factor activity Source: UniProtKB
GO - Biological processi
- RNA polymerase II preinitiation complex assembly Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: FlyBase
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-674695, RNA Polymerase II Pre-transcription Events R-DME-6804756, Regulation of TP53 Activity through Phosphorylation R-DME-73776, RNA Polymerase II Promoter Escape R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-75953, RNA Polymerase II Transcription Initiation R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 7Alternative name(s): Transcription initiation factor TFIID 55 kDa subunit Short name: TAFII-55 Short name: TAFII55 |
Gene namesi | Name:Taf7 Synonyms:anon-84Ec, TAF55 ORF Names:CG2670 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0024909, Taf7 |
Subcellular locationi
Nucleus
Nucleus
- transcription factor TFIID complex Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118883 | 1 – 479 | Transcription initiation factor TFIID subunit 7Add BLAST | 479 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 233 | Phosphoserine1 Publication | 1 | |
Modified residuei | 271 | Phosphoserine1 Publication | 1 | |
Modified residuei | 277 | Phosphoserine1 Publication | 1 | |
Modified residuei | 300 | Phosphoserine1 Publication | 1 | |
Modified residuei | 301 | Phosphoserine1 Publication | 1 | |
Modified residuei | 302 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 367 | Phosphoserine1 Publication | 1 | |
Modified residuei | 371 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9VHY5 |
PTM databases
iPTMneti | Q9VHY5 |
Expressioni
Gene expression databases
Bgeei | FBgn0024909, Expressed in embryo and 20 other tissues |
ExpressionAtlasi | Q9VHY5, baseline and differential |
Genevisiblei | Q9VHY5, DM |
Interactioni
Subunit structurei
Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs).
Protein-protein interaction databases
BioGRIDi | 66120, 5 interactors |
DIPi | DIP-23089N |
IntActi | Q9VHY5, 3 interactors |
STRINGi | 7227.FBpp0081253 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 407 – 453 | Gln-richAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the TAF7 family.Curated
Phylogenomic databases
eggNOGi | KOG4011, Eukaryota |
GeneTreei | ENSGT00940000175094 |
InParanoidi | Q9VHY5 |
OrthoDBi | 1348389at2759 |
PhylomeDBi | Q9VHY5 |
Family and domain databases
CDDi | cd08047, TAF7, 1 hit |
InterProi | View protein in InterPro IPR037817, TAF7 IPR006751, TAFII55_prot_cons_reg |
PANTHERi | PTHR12228, PTHR12228, 1 hit |
Pfami | View protein in Pfam PF04658, TAFII55_N, 1 hit |
SMARTi | View protein in SMART SM01370, TAFII55_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9VHY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSLAVPHLT PISNEHLVSS KEVVFFWKNR IEMFEKKSDK VKQAEHKARD
60 70 80 90 100
DGVELESQFI MRVPKELADT VHEAINAGTI KDRLTIQLDP DLRYGEVRID
110 120 130 140 150
DQILYTKLVD LPTVVESYKT IDNKSFYKSA DICQILICKE EREDETEKES
160 170 180 190 200
PNKNKKKDPN KVDKKYLFPH GITPPCKNVR KRRFRKTLKK KNVEAPEIEK
210 220 230 240 250
EVKHLLRIDN EAVRVDYEII NEEDKPMDEL EQSDIKPYND ADDDLQDEST
260 270 280 290 300
MHASEKTIME MSSQRHLQVE SDDDEASNFP SHRAPNMGVA VHDIFGEEVS
310 320 330 340 350
STDDEDEPDR GNNTMQRRVM EESSRLSADD SRMSDFFGAS GSNTGAGVVK
360 370 380 390 400
MEQNVFSKSM FGHEASSPKL SAAGSSSNLA APSGFYDSQM LAKREEFENM
410 420 430 440 450
EFIDEPQPQY TQQQVQQKIN QLTRQIRELK AQQVQKSTEI ASIQNATLKQ
460 470
RMQETLDNLY TQVIERELEL KDFENMLES
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB7Z0V1 | B7Z0V1_DROME | TBP-associated factor 7, isoform B | Taf7 anon-84Ec, Dmel\CG2670, dTAF[[II]]55, E, TAF | 447 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 269 | V → A in AAL39627 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 348 | V → G in AAC39086 (PubMed:9601978).Curated | 1 | |
Sequence conflicti | 475 – 479 | NMLES → ICWTLKIQI in AAC39086 (PubMed:9601978).Curated | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017096 Genomic DNA Translation: AAC39086.1 AE014297 Genomic DNA Translation: AAF54162.1 AY069482 mRNA Translation: AAL39627.1 |
RefSeqi | NP_649748.1, NM_141491.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0081756; FBpp0081253; FBgn0024909 |
GeneIDi | 40934 |
KEGGi | dme:Dmel_CG2670 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017096 Genomic DNA Translation: AAC39086.1 AE014297 Genomic DNA Translation: AAF54162.1 AY069482 mRNA Translation: AAL39627.1 |
RefSeqi | NP_649748.1, NM_141491.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 66120, 5 interactors |
DIPi | DIP-23089N |
IntActi | Q9VHY5, 3 interactors |
STRINGi | 7227.FBpp0081253 |
PTM databases
iPTMneti | Q9VHY5 |
Proteomic databases
PaxDbi | Q9VHY5 |
Genome annotation databases
EnsemblMetazoai | FBtr0081756; FBpp0081253; FBgn0024909 |
GeneIDi | 40934 |
KEGGi | dme:Dmel_CG2670 |
Organism-specific databases
CTDi | 6879 |
FlyBasei | FBgn0024909, Taf7 |
Phylogenomic databases
eggNOGi | KOG4011, Eukaryota |
GeneTreei | ENSGT00940000175094 |
InParanoidi | Q9VHY5 |
OrthoDBi | 1348389at2759 |
PhylomeDBi | Q9VHY5 |
Enzyme and pathway databases
Reactomei | R-DME-674695, RNA Polymerase II Pre-transcription Events R-DME-6804756, Regulation of TP53 Activity through Phosphorylation R-DME-73776, RNA Polymerase II Promoter Escape R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-75953, RNA Polymerase II Transcription Initiation R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Miscellaneous databases
BioGRID-ORCSi | 40934, 0 hits in 3 CRISPR screens |
GenomeRNAii | 40934 |
PROi | PR:Q9VHY5 |
Gene expression databases
Bgeei | FBgn0024909, Expressed in embryo and 20 other tissues |
ExpressionAtlasi | Q9VHY5, baseline and differential |
Genevisiblei | Q9VHY5, DM |
Family and domain databases
CDDi | cd08047, TAF7, 1 hit |
InterProi | View protein in InterPro IPR037817, TAF7 IPR006751, TAFII55_prot_cons_reg |
PANTHERi | PTHR12228, PTHR12228, 1 hit |
Pfami | View protein in Pfam PF04658, TAFII55_N, 1 hit |
SMARTi | View protein in SMART SM01370, TAFII55_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF7_DROME | |
Accessioni | Q9VHY5Primary (citable) accession number: Q9VHY5 Secondary accession number(s): O76207, Q8T087 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families