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Entry version 143 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

Transcription initiation factor TFIID subunit 7

Gene

Taf7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-674695, RNA Polymerase II Pre-transcription Events
R-DME-6804756, Regulation of TP53 Activity through Phosphorylation
R-DME-73776, RNA Polymerase II Promoter Escape
R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953, RNA Polymerase II Transcription Initiation
R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 7
Alternative name(s):
Transcription initiation factor TFIID 55 kDa subunit
Short name:
TAFII-55
Short name:
TAFII55
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Taf7
Synonyms:anon-84Ec, TAF55
ORF Names:CG2670
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0024909, Taf7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001188831 – 479Transcription initiation factor TFIID subunit 7Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei233Phosphoserine1 Publication1
Modified residuei271Phosphoserine1 Publication1
Modified residuei277Phosphoserine1 Publication1
Modified residuei300Phosphoserine1 Publication1
Modified residuei301Phosphoserine1 Publication1
Modified residuei302Phosphothreonine1 Publication1
Modified residuei367Phosphoserine1 Publication1
Modified residuei371Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VHY5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VHY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0024909, Expressed in embryo and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VHY5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VHY5, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66120, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-23089N

Protein interaction database and analysis system

More...
IntActi
Q9VHY5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081253

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VHY5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi407 – 453Gln-richAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF7 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4011, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000175094

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VHY5

Database of Orthologous Groups

More...
OrthoDBi
1348389at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VHY5

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08047, TAF7, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037817, TAF7
IPR006751, TAFII55_prot_cons_reg

The PANTHER Classification System

More...
PANTHERi
PTHR12228, PTHR12228, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04658, TAFII55_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01370, TAFII55_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VHY5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSLAVPHLT PISNEHLVSS KEVVFFWKNR IEMFEKKSDK VKQAEHKARD
60 70 80 90 100
DGVELESQFI MRVPKELADT VHEAINAGTI KDRLTIQLDP DLRYGEVRID
110 120 130 140 150
DQILYTKLVD LPTVVESYKT IDNKSFYKSA DICQILICKE EREDETEKES
160 170 180 190 200
PNKNKKKDPN KVDKKYLFPH GITPPCKNVR KRRFRKTLKK KNVEAPEIEK
210 220 230 240 250
EVKHLLRIDN EAVRVDYEII NEEDKPMDEL EQSDIKPYND ADDDLQDEST
260 270 280 290 300
MHASEKTIME MSSQRHLQVE SDDDEASNFP SHRAPNMGVA VHDIFGEEVS
310 320 330 340 350
STDDEDEPDR GNNTMQRRVM EESSRLSADD SRMSDFFGAS GSNTGAGVVK
360 370 380 390 400
MEQNVFSKSM FGHEASSPKL SAAGSSSNLA APSGFYDSQM LAKREEFENM
410 420 430 440 450
EFIDEPQPQY TQQQVQQKIN QLTRQIRELK AQQVQKSTEI ASIQNATLKQ
460 470
RMQETLDNLY TQVIERELEL KDFENMLES
Length:479
Mass (Da):55,065
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6B945E4AD207441
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z0V1B7Z0V1_DROME
TBP-associated factor 7, isoform B
Taf7 anon-84Ec, Dmel\CG2670, dTAF[[II]]55, E, TAF
447Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti269V → A in AAL39627 (PubMed:12537569).Curated1
Sequence conflicti348V → G in AAC39086 (PubMed:9601978).Curated1
Sequence conflicti475 – 479NMLES → ICWTLKIQI in AAC39086 (PubMed:9601978).Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF017096 Genomic DNA Translation: AAC39086.1
AE014297 Genomic DNA Translation: AAF54162.1
AY069482 mRNA Translation: AAL39627.1

NCBI Reference Sequences

More...
RefSeqi
NP_649748.1, NM_141491.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081756; FBpp0081253; FBgn0024909

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
40934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2670

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017096 Genomic DNA Translation: AAC39086.1
AE014297 Genomic DNA Translation: AAF54162.1
AY069482 mRNA Translation: AAL39627.1
RefSeqiNP_649748.1, NM_141491.3

3D structure databases

SMRiQ9VHY5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi66120, 5 interactors
DIPiDIP-23089N
IntActiQ9VHY5, 3 interactors
STRINGi7227.FBpp0081253

PTM databases

iPTMnetiQ9VHY5

Proteomic databases

PaxDbiQ9VHY5

Genome annotation databases

EnsemblMetazoaiFBtr0081756; FBpp0081253; FBgn0024909
GeneIDi40934
KEGGidme:Dmel_CG2670

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6879
FlyBaseiFBgn0024909, Taf7

Phylogenomic databases

eggNOGiKOG4011, Eukaryota
GeneTreeiENSGT00940000175094
InParanoidiQ9VHY5
OrthoDBi1348389at2759
PhylomeDBiQ9VHY5

Enzyme and pathway databases

ReactomeiR-DME-674695, RNA Polymerase II Pre-transcription Events
R-DME-6804756, Regulation of TP53 Activity through Phosphorylation
R-DME-73776, RNA Polymerase II Promoter Escape
R-DME-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DME-75953, RNA Polymerase II Transcription Initiation
R-DME-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
40934, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
40934

Protein Ontology

More...
PROi
PR:Q9VHY5

Gene expression databases

BgeeiFBgn0024909, Expressed in embryo and 20 other tissues
ExpressionAtlasiQ9VHY5, baseline and differential
GenevisibleiQ9VHY5, DM

Family and domain databases

CDDicd08047, TAF7, 1 hit
InterProiView protein in InterPro
IPR037817, TAF7
IPR006751, TAFII55_prot_cons_reg
PANTHERiPTHR12228, PTHR12228, 1 hit
PfamiView protein in Pfam
PF04658, TAFII55_N, 1 hit
SMARTiView protein in SMART
SM01370, TAFII55_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF7_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VHY5
Secondary accession number(s): O76207, Q8T087
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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