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Entry version 173 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

FI21225p1

Gene

unc-45

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Hsp90 protein binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperoneARBA annotation, Developmental proteinARBA annotation
Biological processDifferentiationARBA annotation, MyogenesisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI21225p1Imported
Submitted name:
Uncoordinated 45, isoform AImported
Submitted name:
Uncoordinated 45, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-45Imported
Synonyms:Dmel\CG2708Imported, DmUNC-45Imported, DmUnc-45Imported, dUNC-45Imported, dUnc-45Imported, dunc-45Imported, l(3)03692Imported, lincRNA.721Imported, Tom34Imported, unc-45-RAImported, Unc45Imported
ORF Names:CG2708Imported, Dmel_CG2708Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0010812, unc-45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0010812, Expressed in saliva-secreting gland and 42 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9VHW4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081284

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 117TPR_REGIONInterPro annotationAdd BLAST105
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati13 – 46TPRPROSITE-ProRule annotationAdd BLAST34
Repeati50 – 83TPRPROSITE-ProRule annotationAdd BLAST34
Repeati84 – 117TPRPROSITE-ProRule annotationAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili90 – 110Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4151, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007331_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCNAYEK

Database of Orthologous Groups

More...
OrthoDBi
1059433at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR024660, UCS_central_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181, TPR_8, 1 hit
PF11701, UNC45-central, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 2 hits
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9VHW4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNTINSEEV SDAGSYKDKG NEAFKASRWE EAVEHYGKAI KAGSKHKELA
60 70 80 90 100
VFYKNRAAAY LKLGKYENAV EDCTESLKAA PGDPKALFRR AQAYEALEKF
110 120 130 140 150
EEAYKDATAL FKADPGNKTV QPMLQRLHVV VEERSARNAK TSTKVKQMMD
160 170 180 190 200
LTFDLATPID KRRAAANNLV VLAKEQTGAE LLYKDHCIAK VASLTKVEKD
210 220 230 240 250
QDIYVNMVHL VAALCENSVE RTKGVLTELG VPWFMRVLDQ KHENCVSTAQ
260 270 280 290 300
FCLQTILNAL SGLKNKPDSK PEKELCTRNN REIDTLLTCL VYSITDRTIS
310 320 330 340 350
GAARDGVIEL ITRNVHYTAL EWAERLVEIR GLCRLLDVCS ELEDYKYESA
360 370 380 390 400
MDITGSSSTI ASVCLARIYE NMYYDEAKAR FTDQIDEYIK DKLLAPDMES
410 420 430 440 450
KVRVTVAITA LLNGPLDVGN QVVAREGILQ MILAMATTDD ELQQRVSCEC
460 470 480 490 500
LIAASSKKDK AKALCEQGVD ILKRLYHSKN DGIRVRALVG LCKLGSYGGQ
510 520 530 540 550
DAAIRPFGDG AALKLAEACR RFLIKPGKDK DIRRWAADGL AYLTLDAECK
560 570 580 590 600
EKLIEDKASI HALMDLARGG NQSCLYGVVT TFVNLCNAYE KQEMLPEMIE
610 620 630 640 650
LAKFAKQHIP EEHELDDVDF INKRITVLAN EGITTALCAL AKTESHNSQE
660 670 680 690 700
LIARVLNAVC GLKELRGKVV QEGGVKALLR MALEGTEKGK RHATQALARI
710 720 730 740 750
GITINPEVSF SGQRSLDVIR PLLNLLQQDC TALENFESLM ALTNLASMNE
760 770 780 790 800
SVRQRIIKEQ GVSKIEYYLM EDHLYLTRAA AQCLCNLVMS EDVIKMFEGN
810 820 830 840 850
NDRVKFLALL CEDEDEETAT ACAGALAIIT SVSVKCCEKI LAIASWLDIL
860 870 880 890 900
HTLIANPSPA VQHRGIVIIL NMINAGEEIA KKLFETDIME LLSGLGQLPD
910 920 930 940
DTRAKAREVA TQCLAAAERY RIIERSDNAE IPDVFAENSK ISEIIDD
Length:947
Mass (Da):105,048
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0828C92816D479B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54185.1
BT150291 mRNA Translation: AGW04184.1
AE014297 Genomic DNA Translation: ALI30539.1

NCBI Reference Sequences

More...
RefSeqi
NP_001303425.1, NM_001316496.1
NP_524796.1, NM_080057.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0081788; FBpp0081284; FBgn0010812
FBtr0347497; FBpp0312575; FBgn0010812

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2708

UCSC genome browser

More...
UCSCi
CG2708-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54185.1
BT150291 mRNA Translation: AGW04184.1
AE014297 Genomic DNA Translation: ALI30539.1
RefSeqiNP_001303425.1, NM_001316496.1
NP_524796.1, NM_080057.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9VHW4, 1 interactor
STRINGi7227.FBpp0081284

Genome annotation databases

EnsemblMetazoaiFBtr0081788; FBpp0081284; FBgn0010812
FBtr0347497; FBpp0312575; FBgn0010812
GeneIDi44910
KEGGidme:Dmel_CG2708
UCSCiCG2708-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
44910
FlyBaseiFBgn0010812, unc-45

Phylogenomic databases

eggNOGiKOG4151, Eukaryota
GeneTreeiENSGT00940000170706
HOGENOMiCLU_007331_0_0_1
OMAiLCNAYEK
OrthoDBi1059433at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
44910, 1 hit in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44910

Gene expression databases

BgeeiFBgn0010812, Expressed in saliva-secreting gland and 42 other tissues

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
IPR024660, UCS_central_dom
PfamiView protein in Pfam
PF13181, TPR_8, 1 hit
PF11701, UNC45-central, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 4 hits
SUPFAMiSSF48371, SSF48371, 2 hits
SSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005, TPR, 3 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VHW4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VHW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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