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Entry version 173 (19 Jan 2022)
Sequence version 4 (04 Dec 2007)
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Protein
Submitted name:

Centromeric protein-C, isoform A

Gene

Cenp-C

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centromeric protein-C, isoform AImported
Submitted name:
FI18815p1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cenp-CImported
Synonyms:CENP-CImported, cenp-CImported, Cenp-C-RAImported, CenpCImported, CG11745Imported, CG11746Imported, CLD1Imported, dCENP-CImported, Dmel\CG31258Imported, l(2)SH3 157Imported, l(3)85AaImported, l(3)SH157Imported, L1Imported
ORF Names:CG31258Imported, Dmel_CG31258Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0266916, Cenp-C

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0266916

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0266916, Expressed in embryo and 37 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9VHP9, 11 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088911

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni64 – 143DisorderedSequence analysisAdd BLAST80
Regioni174 – 223DisorderedSequence analysisAdd BLAST50
Regioni318 – 341DisorderedSequence analysisAdd BLAST24
Regioni376 – 471DisorderedSequence analysisAdd BLAST96
Regioni567 – 617DisorderedSequence analysisAdd BLAST51
Regioni629 – 661DisorderedSequence analysisAdd BLAST33
Regioni712 – 1077DisorderedSequence analysisAdd BLAST366
Regioni1128 – 1184DisorderedSequence analysisAdd BLAST57
Regioni1198 – 1253DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 125Polar residuesSequence analysisAdd BLAST20
Compositional biasi179 – 208Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi598 – 612Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi631 – 658Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi753 – 767Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi768 – 783Polar residuesSequence analysisAdd BLAST16
Compositional biasi856 – 871Polar residuesSequence analysisAdd BLAST16
Compositional biasi890 – 916Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi922 – 937Polar residuesSequence analysisAdd BLAST16
Compositional biasi938 – 952Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi953 – 972Polar residuesSequence analysisAdd BLAST20
Compositional biasi989 – 1048Polar residuesSequence analysisAdd BLAST60

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4615, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_258159_0_0_1

Database of Orthologous Groups

More...
OrthoDBi
1286361at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VHP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKPQNNDTL ELDDILSQPV KDKERFAAFM MRKLAENKPA QNDNLFGNFK
60 70 80 90 100
LDFDLDFEVP LIKKSQAKPK SKLPEVQPLG ELVSKNSAAT EKVNEPPVDQ
110 120 130 140 150
APNENVPPRR SPTLSPNNRR SMRRSGNVPG SDKLRRHAIR RRSRSCGRQL
160 170 180 190 200
LPEFEETVNL TRSISSPVNF LPEISSTPCT EKQKEEVAKN TTRVETDKPA
210 220 230 240 250
EKPMELSQEP EPENPLQTKV TSPARNPILA AEIEQICKER QSSFHKNVLQ
260 270 280 290 300
LDYSGRAPYS RPPTPSSPSV AGLRRTYTME KGPAPGQLLL SPSHRYDTPS
310 320 330 340 350
KMPVVKAKRF NQELMVPDTP ERQSHDPAWQ SEPQPEFVVP ETQPQDLGEL
360 370 380 390 400
VQTLSRSAIS PIVVINTSNS NRSVRRDAVA MKSVPTSPVT ALSSPPIAPS
410 420 430 440 450
PRRSAAASPQ KSIAQLPRVE ENMDAIMTDD ESDEHPSTVP LNLAPSGGNT
460 470 480 490 500
TRQRRLRSSN RARATIESQE SSMRLLNLHK SVNAKKSKPR KTAIPLNKAP
510 520 530 540 550
SAPINGEQFA RELTRMSNYE ILDLRKRNSL NEIYPLNGHR NHRSEKLILE
560 570 580 590 600
EEIQRELLRR NLMDEAEGLP KQQSSDDSNE DYIPVPPKTQ SLRTKSNDRS
610 620 630 640 650
QGRGRPRSTR RDLPMTTELV NYLGLSQTLE TRRKSSKDGK RCLYTKGSSD
660 670 680 690 700
HEDNDSLSPV KLPRLSKSIQ IVPPPPVSLR YSQSLQNLPC SGKFDFDNVV
710 720 730 740 750
MAAPPDFHDS VNSDAIEIAP PPPEYVVNTR GRSTSGRKSN KNDLVLPPPG
760 770 780 790 800
YEGGQEEEHD ERPSQPRCTA KELQQSTQNG RRAMENELVP PPIEYVEEEN
810 820 830 840 850
RNNEQSRRST KNGNLVDRNT HNAVEYCEPP EPPEYDDSDH GQASILRRSG
860 870 880 890 900
KKLQHSKQSV QKSNKEQIIA PSYENNEDYD SDEEPIYNEE YGKEESQNKN
910 920 930 940 950
VTRRKSDKDE MASHTLECIE GPDPNWNSSC NKQNRNHQNA SKSKENDKLA
960 970 980 990 1000
NRSSKSQKLS NPRQNAVGTE KSVALSNRGE ECTEKSSDVM ESLRVNTPTP
1010 1020 1030 1040 1050
PIDQNSDDVP SRNPSPSRTL LSDDVPSTSR AALEFLQRSQ NMSKSRPPDE
1060 1070 1080 1090 1100
SSADVVFKKP LAPAPRAKSK KGKSEVDKLK LAKMPVEAEE LNTTGIRRSK
1110 1120 1130 1140 1150
RGQVPLQMSW CHTMDPSKFN FMSGFIEPRS KNSKTKKGNL SKAKKASATK
1160 1170 1180 1190 1200
PKPTVEKNLP DNRGPLCSST PRISEKLPGA IPHSESLGLS TLTWEETEVQ
1210 1220 1230 1240 1250
AEAEKVPKKR GRPKKAVGGV QTDTEAEPEP EPEPMISSVA PLTSDQEEPD
1260 1270 1280 1290 1300
VPDEQAPYTE AALGPVVFST PLRDEQEEAS TKLMQWLRGV GDAPPSASMS
1310 1320 1330 1340 1350
DENASVSSAN ELIFCQVDGI DYAFYNTKEK AMLGYMRFKP YQKRSMKQAK
1360 1370 1380 1390 1400
VHPLKLLVQF GEFNVETLAV GEEKEVHSVL RVGDMIEIDR GTRYSIQNAI
1410
DKVSVLMCIR S
Length:1,411
Mass (Da):157,699
Last modified:December 4, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA4E7B6239747DCC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LGX0A0A0B4LGX0_DROME
Centromeric protein-C, isoform B
Cenp-C CENP-C, cenp-C, CenpC, CG11745, CG11746
1,399Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54252.4
BT133292 mRNA Translation: AFC88881.1

NCBI Reference Sequences

More...
RefSeqi
NP_731254.2, NM_169228.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089973; FBpp0088911; FBgn0266916

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41014

UCSC genome browser

More...
UCSCi
CG31258-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54252.4
BT133292 mRNA Translation: AFC88881.1
RefSeqiNP_731254.2, NM_169228.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WSFX-ray1.50B1048-1066[»]
6O2KX-ray1.81A/B1270-1411[»]
6XWUX-ray1.82A1-1411[»]
6XWVX-ray2.27A/B/C/D1-1411[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ9VHP9, 11 interactors
STRINGi7227.FBpp0088911

Genome annotation databases

EnsemblMetazoaiFBtr0089973; FBpp0088911; FBgn0266916
GeneIDi41014
UCSCiCG31258-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41014
FlyBaseiFBgn0266916, Cenp-C
VEuPathDBiVectorBase:FBgn0266916

Phylogenomic databases

eggNOGiKOG4615, Eukaryota
HOGENOMiCLU_258159_0_0_1
OrthoDBi1286361at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
41014, 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
rtv, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41014

Gene expression databases

BgeeiFBgn0266916, Expressed in embryo and 37 other tissues

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VHP9_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VHP9
Secondary accession number(s): Q9VHP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: December 4, 2007
Last modified: January 19, 2022
This is version 173 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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