UniProtKB - Q9VHI4 (SF3B5_DROME)
Protein
Splicing factor 3B subunit 5
Gene
Sf3b5
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Involved in pre-mRNA splicing as component of spliceosome (PubMed:27185460, PubMed:18981222). As part of the spliceosome complex, plays a role in the regulation of spermatogonial differentiation (PubMed:27035939). When associated with the SAGA transcription regulatory histone acetylation (HAT) complex, might be involved in the transcriptional activation of a subset of SAGA-regulated genes (PubMed:27185460).1 Publication2 Publications
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- regulation of gene expression Source: UniProtKB
- spermatogenesis Source: FlyBase
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-DME-72163, mRNA Splicing - Major Pathway R-DME-72165, mRNA Splicing - Minor Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Splicing factor 3B subunit 5ImportedAlternative name(s): Pre-mRNA-splicing factor SF3b 10 kDa subunit |
Gene namesi | Name:Sf3b5Imported ORF Names:CG11985Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0040534, Sf3b5 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- precatalytic spliceosome Source: FlyBase
- SAGA complex Source: UniProtKB
- U2 snRNP Source: UniProtKB
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220759 | 1 – 85 | Splicing factor 3B subunit 5Add BLAST | 85 |
Proteomic databases
PaxDbi | Q9VHI4 |
Expressioni
Gene expression databases
Bgeei | FBgn0040534, Expressed in adult organism and 42 other tissues |
ExpressionAtlasi | Q9VHI4, baseline and differential |
Genevisiblei | Q9VHI4, DM |
Interactioni
Subunit structurei
Component of the SF3B complex (PubMed:27185460, PubMed:18981222). SF3B complex associates with the splicing factor SF3A complex and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP)(PubMed:27185460, PubMed:18981222). Identified in the SAGA transcription regulatory histone acetylation (HAT) complex; the interaction is RNA-independent (PubMed:27185460).
2 PublicationsProtein-protein interaction databases
BioGRIDi | 72500, 45 interactors |
DIPi | DIP-20303N |
IntActi | Q9VHI4, 1 interactor |
STRINGi | 7227.FBpp0081484 |
Family & Domainsi
Sequence similaritiesi
Belongs to the SF3B5 family.Curated
Phylogenomic databases
eggNOGi | KOG3485, Eukaryota |
GeneTreei | ENSGT00390000013215 |
HOGENOMi | CLU_138804_3_1_1 |
InParanoidi | Q9VHI4 |
OMAi | GNPPETQ |
OrthoDBi | 1632322at2759 |
PhylomeDBi | Q9VHI4 |
Family and domain databases
InterProi | View protein in InterPro IPR009846, SF3b5/RDS3-10 IPR017089, Splicing_factor_3B_subunit_5 |
PANTHERi | PTHR20978, PTHR20978, 1 hit |
Pfami | View protein in Pfam PF07189, SF3b10, 1 hit |
PIRSFi | PIRSF037010, Splicing_factor_3B_subunit_5, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VHI4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGERYNIHSQ LEHLQSKYIG TGHADTTKFE WLTNQHRDSL ASYMGHYDIL
60 70 80
NYFAIAENES KARVRFNLME RMLQPCGPPP EKLED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF54327.1 |
RefSeqi | NP_652189.1, NM_143932.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0082006; FBpp0081484; FBgn0040534 |
GeneIDi | 50007 |
KEGGi | dme:Dmel_CG11985 |
UCSCi | CG11985-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF54327.1 |
RefSeqi | NP_652189.1, NM_143932.3 |
3D structure databases
SMRi | Q9VHI4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 72500, 45 interactors |
DIPi | DIP-20303N |
IntActi | Q9VHI4, 1 interactor |
STRINGi | 7227.FBpp0081484 |
Proteomic databases
PaxDbi | Q9VHI4 |
Genome annotation databases
EnsemblMetazoai | FBtr0082006; FBpp0081484; FBgn0040534 |
GeneIDi | 50007 |
KEGGi | dme:Dmel_CG11985 |
UCSCi | CG11985-RA, d. melanogaster |
Organism-specific databases
CTDi | 83443 |
FlyBasei | FBgn0040534, Sf3b5 |
Phylogenomic databases
eggNOGi | KOG3485, Eukaryota |
GeneTreei | ENSGT00390000013215 |
HOGENOMi | CLU_138804_3_1_1 |
InParanoidi | Q9VHI4 |
OMAi | GNPPETQ |
OrthoDBi | 1632322at2759 |
PhylomeDBi | Q9VHI4 |
Enzyme and pathway databases
Reactomei | R-DME-72163, mRNA Splicing - Major Pathway R-DME-72165, mRNA Splicing - Minor Pathway |
Miscellaneous databases
BioGRID-ORCSi | 50007, 0 hits in 1 CRISPR screen |
GenomeRNAii | 50007 |
PROi | PR:Q9VHI4 |
Gene expression databases
Bgeei | FBgn0040534, Expressed in adult organism and 42 other tissues |
ExpressionAtlasi | Q9VHI4, baseline and differential |
Genevisiblei | Q9VHI4, DM |
Family and domain databases
InterProi | View protein in InterPro IPR009846, SF3b5/RDS3-10 IPR017089, Splicing_factor_3B_subunit_5 |
PANTHERi | PTHR20978, PTHR20978, 1 hit |
Pfami | View protein in Pfam PF07189, SF3b10, 1 hit |
PIRSFi | PIRSF037010, Splicing_factor_3B_subunit_5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SF3B5_DROME | |
Accessioni | Q9VHI4Primary (citable) accession number: Q9VHI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families