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Entry version 171 (11 Dec 2019)
Sequence version 4 (01 Jun 2003)
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Protein
Submitted name:

GH10160p

Gene

mura

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GH10160pImported
Submitted name:
Murashka, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:muraImported
Synonyms:CG9382Imported, Dmel\CG9381Imported, MuraImported, mura-RCImported
ORF Names:CG9381Imported, Dmel_CG9381Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0037705 mura

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0037705 Expressed in 30 organ(s), highest expression level in head

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081596

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1077 – 1118RING-typeInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 249DisorderedSequence analysisAdd BLAST249
Regioni291 – 328DisorderedSequence analysisAdd BLAST38
Regioni345 – 391DisorderedSequence analysisAdd BLAST47
Regioni407 – 426DisorderedSequence analysisAdd BLAST20
Regioni431 – 571DisorderedSequence analysisAdd BLAST141
Regioni597 – 781DisorderedSequence analysisAdd BLAST185
Regioni886 – 912DisorderedSequence analysisAdd BLAST27
Regioni1144 – 1173DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 31PolarSequence analysisAdd BLAST31
Compositional biasi47 – 168PolarSequence analysisAdd BLAST122
Compositional biasi169 – 184BasicSequence analysisAdd BLAST16
Compositional biasi185 – 249PolarSequence analysisAdd BLAST65
Compositional biasi292 – 328PolarSequence analysisAdd BLAST37
Compositional biasi351 – 391PolarSequence analysisAdd BLAST41
Compositional biasi431 – 478PolarSequence analysisAdd BLAST48
Compositional biasi493 – 552PolarSequence analysisAdd BLAST60
Compositional biasi615 – 634PolarSequence analysisAdd BLAST20
Compositional biasi677 – 709PolarSequence analysisAdd BLAST33
Compositional biasi736 – 777PolarSequence analysisAdd BLAST42

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0800 Eukaryota
ENOG41121N2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174623

Identification of Orthologs from Complete Genome Data

More...
OMAi
RMLYSPH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13639 zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184 RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VHC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNSNATGGN NHGGSSRRPF TRNSSSVRSQ RGGGGGLGGR MVYSPHTHPH
60 70 80 90 100
VQQQQQQQQQ QQQQGQQRSS NNGNNNLWLG NSPWCNVNLN GGNSGNNNNN
110 120 130 140 150
GGNNNNNNGG NISSNNNSNN VNNKDANPNC DVQTSNSSGT CIYNNSKAHH
160 170 180 190 200
HHNNSNNNGH TQSHIHTNHS LHQGHHHPHH TQMHTPHYPH SSSPQQSNSY
210 220 230 240 250
RQYPPHSYSP NSPHSNGHTN SNASNNPISQ RSNPQAHPNQ NQNSNFYEMC
260 270 280 290 300
TGSGGSHTYG SMSVSLVRLN PARLCLTLGP VTPPAQRVVS FGHRSHSHSN
310 320 330 340 350
SSSNTSSSDQ NQHNPPPRSQ NHHPNPHHSQ YQYQYQYQYR YQYHPPHQYH
360 370 380 390 400
PLHSPQQQTN RQSLPLTRTN SNSINATTFN STNPTTNSNP TDVVNVNSCT
410 420 430 440 450
DIIPYGSSST SSSASSMLPQ QQQHQINNAS APINSHSQGQ GPGNSPNLGH
460 470 480 490 500
NHQRGYNNGN NNRGIGNGIV NGNTNGPPDY MNYRRGVCPA QSRDYSGNGN
510 520 530 540 550
GNNNGHGHNG RRYMSDNLNN PSSSMNGLIN SGHHQRNYND RNLNNHFGNS
560 570 580 590 600
EQNGGPDHRD RAEGSSYNFM RNGGGSGGGG YGRNGSHYQH MAYGNNNGAS
610 620 630 640 650
TSTGGPGLMG ELPSGSGLSG SSLSLNNGPG GLNSDSPSRK RRRISGRPPN
660 670 680 690 700
GPQPQHRCPM AHMQQGSPPL RRPRLRDVAT STQQQQQQYG HQVHHPQQQQ
710 720 730 740 750
QQPPSNYHPM HHHQPQPHYV PQQQVPPPHV QRSPWDLGSS GGSSGGATSS
760 770 780 790 800
SSVGPILQQV QAPPQPPSHQ QAVGYPQAPP QPASLMVDLN LNQVPVNLQL
810 820 830 840 850
RPSEPFWASF CTYPIPAQAR LAPCHLHGVY TQPFPAAPPP GLAAPPLQQQ
860 870 880 890 900
HQPLIQAQQM ISQATLTAQQ QQRDVVAIAT ANLGPIEAPG AHGHPHAHPH
910 920 930 940 950
AHPHAHQLPP GIHITPLSGA AAAAATHHLH STAAAAAAVA AGAQITTAQQ
960 970 980 990 1000
ILFSSDRRTF PPHRRIPRFW TANHGHRHVL PPQSLAAHQA PVQIQATSGI
1010 1020 1030 1040 1050
INPGFLLNFL AMFPLSPYNQ HDLSSGDTNE TENYEALLSL AERLGEAKPR
1060 1070 1080 1090 1100
GLTRNEIDQL PSYKFNPEVH NGDQSSCVVC MCDFELRQLL RVLPCSHEFH
1110 1120 1130 1140 1150
AKCVDKWLRS NRTCPICRGN ASDYFDGVDQ QQQSQATAGA AAALSGTSGG
1160 1170
SAGVAGTSEA SAATANPQQS QAA
Length:1,173
Mass (Da):126,563
Last modified:June 1, 2003 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5A9EF4FB6917A6B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8SX72Q8SX72_DROME
LD30050p
mura CG9382, Dmel\CG9381, Mura, CG9381, Dmel_CG9381
868Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54394.4
BT125858 mRNA Translation: ADU79246.1

NCBI Reference Sequences

More...
RefSeqi
NP_731367.2, NM_169292.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082118; FBpp0081596; FBgn0037705

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41145

UCSC genome browser

More...
UCSCi
CG9381-RC d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54394.4
BT125858 mRNA Translation: ADU79246.1
RefSeqiNP_731367.2, NM_169292.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0081596

Genome annotation databases

EnsemblMetazoaiFBtr0082118; FBpp0081596; FBgn0037705
GeneIDi41145
UCSCiCG9381-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41145
FlyBaseiFBgn0037705 mura

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00940000174623
OMAiRMLYSPH

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41145

Gene expression databases

BgeeiFBgn0037705 Expressed in 30 organ(s), highest expression level in head

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9VHC2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VHC2
Secondary accession number(s): Q9VHC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 171 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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