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Entry version 178 (02 Jun 2021)
Sequence version 2 (01 Oct 2002)
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Protein

Polycomb protein Scm

Gene

Scm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63ZincPROSITE-ProRule annotation1
Metal bindingi66ZincPROSITE-ProRule annotation1
Metal bindingi87ZincPROSITE-ProRule annotation1
Metal bindingi91ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri54 – 93FCS-typePROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-2559580, Oxidative Stress Induced Senescence
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3899300, SUMOylation of transcription cofactors
R-DME-4570464, SUMOylation of RNA binding proteins
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8943724, Regulation of PTEN gene transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycomb protein Scm
Alternative name(s):
Sex comb on midleg protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ScmImported
ORF Names:CG9495
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003334, Scm

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi816E → G: No effect on function. Shows self- and ph-p binding activity comparable to wild-type; when associated with V-846 and R-860. 1 Publication1
Mutagenesisi834I → T: Complete loss of function. Significant loss of self-binding activity. Moderate loss of ph-p binding activity. 1 Publication1
Mutagenesisi836G → D: Complete loss of function. Complete loss of self- and ph-p binding activity. 2 Publications1
Mutagenesisi836G → S: Loss of self- and ph-p binding activity. 2 Publications1
Mutagenesisi840 – 841LL → SS: Several-fold reduction of self-binding activity. Partial loss of ph-p binding activity. 1 Publication2
Mutagenesisi846M → V: No effect on function. Shows self- and ph-p binding activity comparable to wild-type; when associated with G-816 and R-860. 1 Publication1
Mutagenesisi848Missing : Complete loss of function. Significant loss of self-binding activity. Partial loss of ph-p binding activity. 1 Publication1
Mutagenesisi851M → R: Complete loss of function. Complete loss of self- and ph-p binding activity. 1 Publication1
Mutagenesisi854K → A: Partial loss of self- and ph-p binding activity. 1 Publication1
Mutagenesisi860K → E: Complete loss of function. Partial loss of self-binding activity. Complete loss of ph-p binding activity. 1 Publication1
Mutagenesisi860K → R: No effect on function. Shows self- and ph-p binding activity comparable to wild-type; when associated with G-816 and V-846. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001143331 – 877Polycomb protein ScmAdd BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei546Phosphothreonine1 Publication1
Modified residuei549Phosphoserine1 Publication1
Modified residuei550Phosphoserine1 Publication1
Modified residuei585Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VHA0

PRoteomics IDEntifications database

More...
PRIDEi
Q9VHA0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VHA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Levels are highest in 0-2 hours embryos and at lower levels during later embryonic and larval stages. A modest increase in expression is seen during the pupal stage. Expressed throughout the 9 hours embryo. After 12 hours expression is concentrated in the central nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003334, Expressed in female gonad and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VHA0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VHA0, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Scm associates with the PRC1 core complex containing PSC, PC, PH and Sce/RING1. Forms homotypic and heterotypic interactions.

Interacts with the SAM domain of ph-p via its SAM domain in vitro.

Interacts with corto in vitro.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
66327, 57 interactors

Database of interacting proteins

More...
DIPi
DIP-17570N

Protein interaction database and analysis system

More...
IntActi
Q9VHA0, 22 interactors

Molecular INTeraction database

More...
MINTi
Q9VHA0

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0081580

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1877
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VHA0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9VHA0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati175 – 273MBT 1Sequence analysisAdd BLAST99
Repeati281 – 382MBT 2Sequence analysisAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini806 – 876SAMPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57DisorderedSequence analysisAdd BLAST57
Regioni535 – 621DisorderedSequence analysisAdd BLAST87
Regioni652 – 692DisorderedSequence analysisAdd BLAST41
Regioni713 – 735DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi537 – 572Polar residuesSequence analysisAdd BLAST36
Compositional biasi582 – 621Polar residuesSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SAM domain is essential for function.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SCM family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri54 – 93FCS-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3766, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000175826

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015000_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VHA0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KILNNAM

Database of Orthologous Groups

More...
OrthoDBi
229086at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VHA0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004092, Mbt
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR021987, SLED
IPR012313, Znf_FCS
IPR010507, Znf_MYM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02820, MBT, 2 hits
PF00536, SAM_1, 1 hit
PF12140, SLED, 1 hit
PF06467, zf-FCS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00561, MBT, 2 hits
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51079, MBT, 2 hits
PS50105, SAM_DOMAIN, 1 hit
PS51024, ZF_FCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9VHA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGRDSSTS SGSNSAAPGA STNATSSASA SASSTSTSAS PGSTTSPAST
60 70 80 90 100
QRQRGRPAKR ATCTWCGEGK LPLQYVLPTQ TGKKEFCSET CIAEFRKAYS
110 120 130 140 150
KGACTQCDNV IRDGAPNKEF CSIMCMNKHQ KKNCSTRHSG GSASGKGLAE
160 170 180 190 200
SERKLLASGA PAPTGPFQYE SFHVFDWDAY LEETGSEAAP AKCFKQAQNP
210 220 230 240 250
PNNDFKIGMK LEALDPRNVT STCIATVVGV LGSRLRLRLD GSDSQNDFWR
260 270 280 290 300
LVDSTEIHAI GHCEKNGGML QPPLGFRMNA SSWPGYLCKI LNNAMVAPEE
310 320 330 340 350
IFQPEPPEPE ENLFKVGQKL EAVDKKNPQL ICCATVDAIK DDQIHVTFDG
360 370 380 390 400
WRGAFDYWCN YRSRDIFPAG WCARSCHPMQ PPGHKSRMDS SSSKQRCPRP
410 420 430 440 450
RYTVVAESEA MVPASPATAH FHPNCKGGPF INNSKLPCMV TGPTYQTLAK
460 470 480 490 500
LCLQEVLAAS TDTQQLSKLL FALEGDVHIV TAAGKNFTVK IPSPMRMKDD
510 520 530 540 550
ESLAQFIETL CTTCRACANL ISLVHETEEC KKCANSRKRQ LTQSATPPSS
560 570 580 590 600
PVLADKRNRQ SNSATTSPSE KIIKQELAVK SPVESKSKTS TNNGKEPASQ
610 620 630 640 650
QNSNHSLNNN NNSASKSSNK VVIKSEPNGA NAQTSSTTQA LRKVRFQHHA
660 670 680 690 700
NTNTNSSATN GNQDTSQTTH VSTSHCSSSS TSSSTSLAGG SANTSTIGKY
710 720 730 740 750
LAPLVAEVHP EQANVKPSNS YYKSPTTLSS SASLPTSVST PFTGCQSASS
760 770 780 790 800
TALAAGGVTA AKAATAPAGA AATAGASPSY TAITSPVSTP TSALANSHLR
810 820 830 840 850
SQPIDWTIEE VIQYIESNDN SLAVHGDLFR KHEIDGKALL LLNSEMMMKY
860 870
MGLKLGPALK ICNLVNKVNG RRNNLAL
Length:877
Mass (Da):93,551
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7859FD0C7B91589E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K6M7A0A0B4K6M7_DROME
Sex comb on midleg, isoform B
Scm Dmel\CG9495, l(3)85Ef, SCM, scm, Su(z)302
877Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U49793 mRNA Translation: AAB57632.1
AE014297 Genomic DNA Translation: AAF54419.2
BT001565 mRNA Translation: AAN71320.1

NCBI Reference Sequences

More...
RefSeqi
NP_001247006.1, NM_001260077.2
NP_731385.1, NM_169299.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082102; FBpp0081580; FBgn0003334
FBtr0306008; FBpp0297150; FBgn0003334

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9495

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49793 mRNA Translation: AAB57632.1
AE014297 Genomic DNA Translation: AAF54419.2
BT001565 mRNA Translation: AAN71320.1
RefSeqiNP_001247006.1, NM_001260077.2
NP_731385.1, NM_169299.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PK1X-ray1.80B/D795-871[»]
1PK3X-ray1.85A/B/C795-871[»]
2R57X-ray2.20A175-435[»]
2R58X-ray2.00A175-435[»]
2R5AX-ray2.30A175-435[»]
2R5MX-ray2.65A175-435[»]
5J8YX-ray1.98A/B803-877[»]
SMRiQ9VHA0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi66327, 57 interactors
DIPiDIP-17570N
IntActiQ9VHA0, 22 interactors
MINTiQ9VHA0
STRINGi7227.FBpp0081580

PTM databases

iPTMnetiQ9VHA0

Proteomic databases

PaxDbiQ9VHA0
PRIDEiQ9VHA0

Genome annotation databases

EnsemblMetazoaiFBtr0082102; FBpp0081580; FBgn0003334
FBtr0306008; FBpp0297150; FBgn0003334
GeneIDi41168
KEGGidme:Dmel_CG9495

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41168
FlyBaseiFBgn0003334, Scm

Phylogenomic databases

eggNOGiKOG3766, Eukaryota
GeneTreeiENSGT00940000175826
HOGENOMiCLU_015000_0_0_1
InParanoidiQ9VHA0
OMAiKILNNAM
OrthoDBi229086at2759
PhylomeDBiQ9VHA0

Enzyme and pathway databases

ReactomeiR-DME-2559580, Oxidative Stress Induced Senescence
R-DME-3108214, SUMOylation of DNA damage response and repair proteins
R-DME-3899300, SUMOylation of transcription cofactors
R-DME-4570464, SUMOylation of RNA binding proteins
R-DME-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8943724, Regulation of PTEN gene transcription

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
41168, 0 hits in 3 CRISPR screens
EvolutionaryTraceiQ9VHA0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
41168

Protein Ontology

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PROi
PR:Q9VHA0

Gene expression databases

BgeeiFBgn0003334, Expressed in female gonad and 37 other tissues
ExpressionAtlasiQ9VHA0, baseline and differential
GenevisibleiQ9VHA0, DM

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR004092, Mbt
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR021987, SLED
IPR012313, Znf_FCS
IPR010507, Znf_MYM
PfamiView protein in Pfam
PF02820, MBT, 2 hits
PF00536, SAM_1, 1 hit
PF12140, SLED, 1 hit
PF06467, zf-FCS, 1 hit
SMARTiView protein in SMART
SM00561, MBT, 2 hits
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079, MBT, 2 hits
PS50105, SAM_DOMAIN, 1 hit
PS51024, ZF_FCS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCM_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VHA0
Secondary accession number(s): Q24191
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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