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Protein
Submitted name:

GH12714p

Gene

PpD3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein serine/threonine phosphatase activity Source: FlyBase

GO - Biological processi

  • mitotic cell cycle Source: FlyBase
  • protein dephosphorylation Source: FlyBase

Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

ReactomeiR-DME-5675221 Negative regulation of MAPK pathway
R-DME-8939211 ESR-mediated signaling

Names & Taxonomyi

Protein namesi
Submitted name:
GH12714pImported
Submitted name:
Protein phosphatase 5Imported (EC:3.1.3.16Imported)
Submitted name:
Protein phosphatase D3, isoform AImported
Submitted name:
Protein phosphatase D3, isoform BImported
Submitted name:
Protein phosphatase D3, isoform CImported
Gene namesi
Name:PpD3Imported
Synonyms:D3Imported, Dmel\CG8402Imported, DmPP5Imported, DmPpp5-85EImported, PP5Imported, PP5 85EImported, Pp5-85EImported, PPP5Imported
ORF Names:CG8402Imported, Dmel_CG8402Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0005777 PpD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0005777 Expressed in 49 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

IntActiQ9VH81, 583 interactors
STRINGi7227.FBpp0081606

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 150TPR_REGIONInterPro annotationAdd BLAST102
Repeati49 – 82TPRPROSITE-ProRule annotationAdd BLAST34
Repeati117 – 150TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0376 Eukaryota
COG0639 LUCA
GeneTreeiENSGT00530000063173
KOiK04460
OMAiLYPNHFF
OrthoDBiEOG091G0589

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR013235 PPP_dom
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR011236 Ser/Thr_PPase_5
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11668:SF391 PTHR11668:SF391, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF08321 PPP5, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VH81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSELEVQK AADCQQEAKV PASVEITGSK QPEEDTNART KAELDFAAAE
60 70 80 90 100
QYKNQGNEML KTKEFSKAID MYTKAIELHP NSAIYYANRS LAHLRQESFG
110 120 130 140 150
FALQDGVSAV KADPAYLKGY YRRAAAHMSL GKFKQALCDF EFVAKCRPND
160 170 180 190 200
KDAKLKFTEC NKIVKMRAFE RAIAVDKPEK TLSEMYSDME NITIEDDYKG
210 220 230 240 250
PQLEDGKVTL KFMKELMEHY KAQKRLHRKF AYKILCEIDT YMRAQPSLVD
260 270 280 290 300
ITVPDEEKFT ICGDIHGQFY DLMNIFEING LPSEKNPYLF NGDFVDRGSF
310 320 330 340 350
SVECIFTLFG FKLLYPNHFF LARGNHESIN MNQMYGFTGE VTAKYTSAMA
360 370 380 390 400
DIFTQVFNWL PLCHCINQKI LVMHGGLFST EDVTLDHIRR IERNCQPPEE
410 420 430 440 450
GLMCELLWSD PQQWMGLGQS KRGVGIQFGP DVTEKFCKDN NLDYIIRSHE
460 470 480 490 500
VKDMGYEVAH NGKCITVFSA PNYCDTMGNM GAFITITGNN LKPNYKSFEA
510 520
VPHPDVKPMA YANSLMNWLA
Length:520
Mass (Da):59,264
Last modified:May 1, 2000 - v1
Checksum:i4719EDD9BDC38F32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54438.1
AY058356 mRNA Translation: AAL13585.1
AE014297 Genomic DNA Translation: AAN13442.1
AE014297 Genomic DNA Translation: AGB95815.1
AJ271781 mRNA Translation: CAB99478.1
RefSeqiNP_001262433.1, NM_001275504.2
NP_524946.1, NM_080207.3
NP_731398.1, NM_169307.2
UniGeneiDm.6984

Genome annotation databases

EnsemblMetazoaiFBtr0082128; FBpp0081606; FBgn0005777
FBtr0082129; FBpp0081607; FBgn0005777
FBtr0331693; FBpp0304082; FBgn0005777
GeneIDi49779
KEGGidme:Dmel_CG8402
UCSCiCG8402-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54438.1
AY058356 mRNA Translation: AAL13585.1
AE014297 Genomic DNA Translation: AAN13442.1
AE014297 Genomic DNA Translation: AGB95815.1
AJ271781 mRNA Translation: CAB99478.1
RefSeqiNP_001262433.1, NM_001275504.2
NP_524946.1, NM_080207.3
NP_731398.1, NM_169307.2
UniGeneiDm.6984

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VH81, 583 interactors
STRINGi7227.FBpp0081606

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082128; FBpp0081606; FBgn0005777
FBtr0082129; FBpp0081607; FBgn0005777
FBtr0331693; FBpp0304082; FBgn0005777
GeneIDi49779
KEGGidme:Dmel_CG8402
UCSCiCG8402-RA d. melanogaster

Organism-specific databases

CTDi49779
FlyBaseiFBgn0005777 PpD3

Phylogenomic databases

eggNOGiKOG0376 Eukaryota
COG0639 LUCA
GeneTreeiENSGT00530000063173
KOiK04460
OMAiLYPNHFF
OrthoDBiEOG091G0589

Enzyme and pathway databases

ReactomeiR-DME-5675221 Negative regulation of MAPK pathway
R-DME-8939211 ESR-mediated signaling

Miscellaneous databases

ChiTaRSiPpD3 fly
GenomeRNAii49779

Gene expression databases

BgeeiFBgn0005777 Expressed in 49 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR013235 PPP_dom
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR011236 Ser/Thr_PPase_5
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11668:SF391 PTHR11668:SF391, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF08321 PPP5, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VH81_DROME
AccessioniPrimary (citable) accession number: Q9VH81
Secondary accession number(s): Q26244
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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