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Protein

Mannose-6-phosphate isomerase

Gene

Dmel\CG8417

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (Dmel\CG8417)
  2. Probable phosphomannomutase (CG10688)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86ZincUniRule annotation1
Metal bindingi88ZincUniRule annotation1
Metal bindingi113ZincUniRule annotation1
Metal bindingi241ZincUniRule annotation1
Active sitei260UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-446205 Synthesis of GDP-mannose
UniPathwayiUPA00126; UER00423

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.8UniRule annotation)
Gene namesi
Name:Dmel\CG8417Imported
ORF Names:CG8417Imported, Dmel_CG8417Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037744 CG8417

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0037744

Interactioni

Protein-protein interaction databases

IntActiQ9VH77, 16 interactors
STRINGi7227.FBpp0081609

Family & Domainsi

Sequence similaritiesi

Belongs to the mannose-6-phosphate isomerase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2757 Eukaryota
COG1482 LUCA
GeneTreeiENSGT00390000016075
KOiK01809
OMAiLCYEKLM
OrthoDBiEOG091G078D

Family and domain databases

Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR001250 Man6P_Isoase-1
IPR016305 Mannose-6-P_Isomerase
IPR018050 Pmannose_isomerase-type1_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR10309 PTHR10309, 1 hit
PfamiView protein in Pfam
PF01238 PMI_typeI, 1 hit
PIRSFiPIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSiPR00714 MAN6PISMRASE
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR00218 manA, 1 hit
PROSITEiView protein in PROSITE
PS00965 PMI_I_1, 1 hit
PS00966 PMI_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VH77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTGWVKNY GWGRKGINSA VAQLAMANDP DFRLNEEETY AEMWMGTHVC
60 70 80 90 100
GVSVVKETGE TLDRVLKKDL SYLFKVLSIN KALSIQVHPN KCEAERLHKE
110 120 130 140 150
RPDIYKDPNH KPELAIALTP FLALVGFMSA EDIRDYIDEF QPLSKLIGKE
160 170 180 190 200
AVDQLHDSTN SESVKLCYEK LMKTEEPVIA KCISEIAKDY QNELKSNDLL
210 220 230 240 250
EVFTKVNKDF PGDVGVLSLF FLNLIRLQPG QAIYLGANEI HAYLDGDCVE
260 270 280 290 300
CMACSDNVIR AGLTPKYKDV DQLLESVIFE SSYKDRKEFI PYRIDDQVQV
310 320 330 340 350
YIPPVSDFAV INVNIEHSLE SYKLEIQAFG SILIVLKGSR ILKLKTQQGD
360 370 380 390
KEILVTRGSI VYIPVEAAPE IEFAQSDDCD EDFSGYIATS NYFRVP
Length:396
Mass (Da):44,774
Last modified:May 1, 2000 - v1
Checksum:i1EB1176951903C2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54442.1
AY059444 mRNA Translation: AAL13350.1
AY075552 mRNA Translation: AAL68359.1
RefSeqiNP_649940.1, NM_141683.3
UniGeneiDm.4351

Genome annotation databases

EnsemblMetazoaiFBtr0082131; FBpp0081609; FBgn0037744
GeneIDi41192
KEGGidme:Dmel_CG8417
UCSCiCG8417-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VH77_DROME
AccessioniPrimary (citable) accession number: Q9VH77
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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